Effect of Pentoxifylline on the Healing of Ischemic Colorectal Anastomoses

Parra-Membríves, Pablo; Ruiz-Luque, Virgilio; Escudero-Severín, Carlos; Aguilar-Luque, José; Méndez-García, Virginia

doi:10.1007/s10350-006-0803-z

Cited by 27 publications

(28 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The underlying reason for the reduction in grading of perianastomotic fibrosis was claimed to be ischemia and neovascularization. In the current study, unlike the investigation of Parra-Membrives et al, [9] we determined a higher level of mucosal re-epithelization in the vinpocetine and pentoxifylline groups. However, despite higher values for inflammatory cells, neovascularization, muscular layer continuity, and PNL presence, the differences were not statistically significant.…”

Section: Discussioncontrasting

confidence: 73%

“…In the study of Parra-Membrives et al [9] focusing on the effects of pentoxifylline over ischemic colorectal anastomoses, pentoxifylline and control groups showed similar mucosal re-epithelization; presence of inflammatory cells in the granulation tissue; and lymphocyte, histiocyte, and fibroblast infiltration. No significant alteration was observed with regard to destruction of the muscular layer.…”

Section: Discussionmentioning

confidence: 90%

“…[7,8] The ischemic wound is known to be easily infected and to have a difficult healing process. [8,9] Prevention or reduction of ischemic damage is among the objectives of surgery.…”

Section: Resultsmentioning

confidence: 99%

“…Although the incidence of this complication has been significantly reduced with the application of modern surgical techniques, it is still an important complication. [4,9,[12][13][14] As with all anastomoses, tissue blood flow and oxygenation are considerable factors in colonic anastomoses. [5,12] In comparison with other gastrointestinal components, the colon is known to present higher anastomotic leak rates due to its certain anatomical and biological characteristics, such as low collagen content, high collagenase activity, reduced collateral circulation, and absence of a serosa in the extraperitoneal rectum.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

İskemik kolon anastomozlarının iyileşmesi üzerine pentoxifylline ve vinpocetinenin etkisi. (Deneysel Çalışma)

Sümer¹

2011

Ulus Travma Acil Cerrahi Derg

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 73%

Section: Discussionmentioning

confidence: 90%

“…[7,8] The ischemic wound is known to be easily infected and to have a difficult healing process. [8,9] Prevention or reduction of ischemic damage is among the objectives of surgery.…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

İskemik kolon anastomozlarının iyileşmesi üzerine pentoxifylline ve vinpocetinenin etkisi. (Deneysel Çalışma)

Sümer¹

2011

Ulus Travma Acil Cerrahi Derg

View full text Add to dashboard Cite

“…This observation reinforces the importance of experimental studies evaluating the healing of anastomoses in the left colon, especially studies using animals of only a single gender. Studies have habitually used animals of male gender [1][2][3][4][6][7][8][10][11][12][13]16,18 . even though there is no restriction on using females, purely from the point of view of location of the PP 5,14,21 .…”

Section: Discussionmentioning

confidence: 99%

Is peritoneal reflection the best anatomical repair landmark in experimental colorectal surgery on rats?

et al. 2009

View full text Add to dashboard Cite

PURPOSE: To validate Peyer's patch as an anatomical repair landmark for colorectal surgery in rats and to measure the collagen content in segments of the colon containing or not containing Peyer's patch. METHODS: The distance between Peyer's patch and the peritoneal reflection was measured in forty-five Wistar rats. The colon and rectum were resected for quantification of collagen content by means of computer-assisted image analysis in regions of the colon with and without Peyer's patch. RESULTS: There was great variation in the distance between Peyer's patch and the peritoneal reflection when the male and female rats were considered as a single group (p=0.04). Comparison between the genders showed that the distance between the patch and the peritoneal reflection was greater in female than in male rats (p=0.001). The colonic segment containing Peyer's patch was observed to have lower tissue collagen content than the segment in which this structure was not present (p=0.02). CONCLUSION: Peyer's patch can be indicated as an anatomical repair landmark, and there is a need to study the healing of colorectal anastomoses in rats based on differing quantities of tissue collagen existing in the colonic wall with or without this structure.

show abstract

International consensus statement regarding the use of animal models for research on anastomoses in the lower gastrointestinal tract

Bosmans

Moossdorff

Beek

et al. 2016

Int J Colorectal Dis

View full text Add to dashboard Cite

PurposeThis project aimed to reach consensus on the most appropriate animal models and outcome measures in research on anastomoses in the lower gastrointestinal tract (GIT). The physiology of anastomotic healing remains an important research topic in gastrointestinal surgery. Recent results from experimental studies are limited with regard to comparability and clinical translation.MethodsPubMed and EMBASE were searched for experimental studies investigating anastomotic healing in the lower GIT published between January 1, 2000 and December 31, 2014 to assess currently used models. All corresponding authors were invited for a Delphi-based analysis that consisted of two online survey rounds followed by a final online recommendation survey to reach consensus on the discussed topics.ResultsTwo hundred seventy-seven original articles were retrieved and 167 articles were included in the systematic review. Mice, rats, rabbits, pigs, and dogs are currently being used as animal models, with a large variety in surgical techniques and outcome measures. Forty-four corresponding authors participated in the Delphi analysis. In the first two rounds, 39/44 and 35/39 participants completed the survey. In the final meeting, 35 experts reached consensus on 76/122 items in six categories. Mouse, rat, and pig are considered appropriate animal models; rabbit and dog should be abandoned in research regarding bowel anastomoses. ARRIVE guidelines should be followed more strictly.ConclusionsConsensus was reached on several recommendations for the use of animal models and outcome measurements in research on anastomoses of the lower GIT. Future research should take these suggestions into account to facilitate comparison and clinical translation of results.Electronic supplementary materialThe online version of this article (doi:10.1007/s00384-016-2550-5) contains supplementary material, which is available to authorized users.

show abstract

Effect of Pentoxifylline on the Healing of Ischemic Colorectal Anastomoses

Abstract: Selective anastomotic devascularization induces ischemia and impairs experimental anastomotic healing, increasing leakage rate. These effects may be ameliorated by pentoxifylline administration.

Cited by 27 publications

References 33 publications

İskemik kolon anastomozlarının iyileşmesi üzerine pentoxifylline ve vinpocetinenin etkisi. (Deneysel Çalışma)

İskemik kolon anastomozlarının iyileşmesi üzerine pentoxifylline ve vinpocetinenin etkisi. (Deneysel Çalışma)

Is peritoneal reflection the best anatomical repair landmark in experimental colorectal surgery on rats?

International consensus statement regarding the use of animal models for research on anastomoses in the lower gastrointestinal tract

Contact Info

Product

Resources

About