Effect of Pentylenetetrazole-Induced Seizures on Serum Brain-Derived Neurotrophic Factor (BDNF) Levels and Cognition in Rats

Abstract

later responded favorably with rituximab but after 6 months, developed right-sided focal motor seizures with lower limb onset which over a short period of time progressed to EPC. EEG revealed slowing in bilateral hemispheres with left hemispherical interictal epileptiform discharges and seizure onset from left-sided (central and midline) channels. MRI revealed T2/FLAIR hyperintense signal in left frontal parasagittal region corresponding to the leg region. She was again given rituximab with modest benefit. Conclusion:Rassmussen's encephalitis can be rarely bilateral. Management of such patients is difficult since surgical option is not feasible owing to bilaterality.