Background: Malaria is a major health problem in many parts of India. Several factors have beenattributed to increased morbidity and mortality in malaria with altered hematological andcoagulation parameters. This study was conducted to compare the coagulation parameters ofmalaria cases with those of the healthy carriers. Aims and objectives: To evaluate coagulationabnormalities in patients of malaria and to study the difference in coagulation parameters betweenmalaria patients and healthy controls and to determine the level of significance of the difference.Materials and methodology: This prospective comparative study of 300 patients with laboratorydiagnosed malaria patients (cases) and 300 healthy individuals (controls) was carried out in theDepartment of Pathology in a tertiary care, V. S. General Hospital, Ahmedabad. Result: Comparisonof platelet count, PT, and aPTT between case groups and control groups was statistically significant(p<0.001). Conclusion: There is a significant difference between the platelet count, PT, and aPTTvalues of the two groups. This indicates that in patients with malaria, there is an activation ofintrinsic and extrinsic pathways of coagulation.

later responded favorably with rituximab but after 6 months, developed right-sided focal motor seizures with lower limb onset which over a short period of time progressed to EPC. EEG revealed slowing in bilateral hemispheres with left hemispherical interictal epileptiform discharges and seizure onset from left-sided (central and midline) channels. MRI revealed T2/FLAIR hyperintense signal in left frontal parasagittal region corresponding to the leg region. She was again given rituximab with modest benefit. Conclusion:Rassmussen's encephalitis can be rarely bilateral. Management of such patients is difficult since surgical option is not feasible owing to bilaterality.