Effect of Perflubron-induced lung growth on pulmonary vascular remodeling in congenital diaphragmatic hernia

Shah, Mansi; Phillips, Michael; Bryner, Benjamin S.; Hirschl, Ronald B.; Mychaliska, George B.; McLean, Sean E.

doi:10.1007/s00383-016-3887-0

Cited by 6 publications

(1 citation statement)

References 25 publications

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“…The authors observed substantial lung growth in the PILG group, which was accelerated in the subgroup of patients receiving early surgical repair. Histology and immunohistochemistry showed that PILG had no effect on reducing pulmonary vascular remodeling, 66 but played a potential role in diminishing macrophagic activity. 66 Therefore, the authors concluded that the use of PILG was effective at inducing lung growth but alone did not confer a survival advantage because of the lack of effect upon pulmonary hypertension.…”

Section: Use Of Pfcs In Cdhmentioning

confidence: 95%

Perfluorocarbons in Research and Clinical Practice: A Narrative Review

Nocentini,

MacLaren,

Bartlett

et al. 2023

ASAIO Journal

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Perfluorocarbons (PFCs) are organic liquids derived from hydrocarbons in which some of the hydrogen atoms have been replaced by fluorine atoms. They are chemically and biologically inert substances with a good safety profile. They are stable at room temperature, easy to store, and immiscible in water. Perfluorocarbons have been studied in biomedical research since 1960 for their unique properties as oxygen carriers. In particular, PFCs have been used for liquid ventilation in unusual environments such as deep-sea diving and simulations of zero gravity, and more recently for drug delivery and diagnostic imaging. Additionally, when delivered as emulsions, PFCs have been used as red blood cell substitutes. This narrative review will discuss the multifaceted utilization of PFCs in therapeutics, diagnostics, and research. We will specifically emphasize the potential role of PFCs as red blood cell substitutes, as airway mechanotransducers during artificial placenta procedures, as a means to improve donor organ perfusion during the ex vivo assessment, and as an adjunct in cancer therapies because of their ability to reduce local tissue hypoxia.

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Section: Use Of Pfcs In Cdhmentioning

confidence: 95%