Effect of perfluorochemical liquid ventilation on cardiac output and blood pressure variability in neonatal piglets with respiratory insufficiency

Degraeuwe, Pieter; Vos, Gijs D.; Geskens, Gijs G.; Geilen, Jan M.; Blanco, Carlos E.

doi:10.1002/1099-0496(200008)30:2<114::aid-ppul6>3.0.co;2-0

Cited by 14 publications

(19 citation statements)

References 67 publications

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“…In this study, we were able to avoid the high dynamic airway pressures that may result in hemodynamic impairment or acidosis as described by other authors during TLV (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37). The only hemodynamic abnormality observed in the current study was a sinusoidal pattern of mean arterial pressure related to the ventilator phase (20,21,38). The sinusoidal variation of mean arterial pressure that we observed during total liquid ventilation is likely a result of the large tidal volumes (19 Ϯ 0.5 mL·kg Ϫ1 ) used in this study.…”

Section: Discussionsupporting

confidence: 56%

A prototype of a liquid ventilator using a novel hollow-fiber oxygenator in a rabbit model

Tredici

Komori

Funakubo

et al. 2004

Critical Care Medicine

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Section: Discussionsupporting

confidence: 56%

A prototype of a liquid ventilator using a novel hollow-fiber oxygenator in a rabbit model

Tredici

Komori

Funakubo

et al. 2004

Critical Care Medicine

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“…Although not statistically different, a higher mean arterial pressure was recorded in the gas-ventilated animals than in all the TLV animals. It is well known 11,44,45 that TLV can slightly affect blood pressure due to the high density of PFC that partially reduces the venous return affecting the cardiac output. However, an adequate arterial blood pressure and heart rate were maintained during all the experiments in the TLV groups, both during collapse sequences and during standard TLV setting.…”

Section: Discussionmentioning

confidence: 99%

Effect of Repeated Induced Airway Collapse During Total Liquid Ventilation

Bagnoli¹,

Tredici²,

Seetharamaiah³

et al. 2007

ASAIO Journal

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Negative pressure generated during the expiratory phase of total liquid ventilation (TLV) may induce airway collapse. Evaluation of the effect of repeated airway collapse is crucial to optimize this technique. A total of 24 New Zealand White rabbits were randomly divided into four groups. Ventilation was performed for 6 hours with different strategies: conventional gas ventilation, TLV without airway collapse, and TLV with collapse induced in either 75 or 150 sequential breaths. In the treated groups, airway collapse was induced by increasing the perfluorocarbon drainage velocity while maintaining the minute ventilation constant. Airway pressure, gas exchange, and blood pressure were monitored at 30-minute intervals. At the end of the experiment, airway and lung parenchyma specimens were processed for light microscopy. No evidence of fluorothorax was noticed in any of the four groups at autopsy examination. Minimal signs of inflammation were noticed in all airway and lung parenchyma specimens, but no evident structural alteration was visible. Adequate gas exchange and systemic blood pressure were maintained during all the studies. Repeated airway collapse is not associated with structural changes in the respiratory system and does not alter the gas exchange ability of the lungs.

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“…The pressure placed on the great vessels and the pulmonary vasculature reduces the filling of the right ventricle and increases pulmonary vascular resistance (PVR), resulting in impairment of cardiac function (3). Furthermore, TLV compromises hemodynamics as a result of dramatic respiratory‐related fluctuation of arterial blood pressure (4). Previous studies have demonstrated that hemodynamics in animals with normal cardiac function could be successfully maintained during TLV (5).…”

mentioning

confidence: 99%

The Hemodynamic Effect of Total Liquid Ventilation in Piglets With Reduced Cardiac Function After Cardiopulmonary Bypass

Jiang

et al. 2011

Artificial Organs

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Total liquid ventilation (TLV) is a promising treatment for severe lung injury and heart resuscitation. We aim to investigate the hemodynamic effect of TLV in piglets with preexisting cardiac dysfunction. After onset of cardiopulmonary dysfunction induced by cardiopulmonary bypass (CPB), piglets were randomly treated with TLV (n = 6) or conventional gas ventilation (n = 6) for 240 min. Hemodynamics was monitored before and at a 30-min interval after CPB. CPB with cardiac arrest resulted in significant decrease in cardiac index (CI) (96.19 ± 6.74 vs. 48.58 ± 3.96 mL/min/kg, P < 0.001) and increase of pulmonary vascular resistance (PVR) (1123.38 ± 198.97 vs. 8180.62 ± 1041.35 dyne·s/cm(5), P < 0.001). Compared with conventional gas ventilation, there was no further significant decrease of CI or increase of PVR during TLV throughout the experiment. No significant difference was observed on other hemodynamic variables including heart rate, mean arterial pressure, mean pulmonary arterial pressure, and central venous pressure between both groups. The fluctuation of mean arterial blood pressure was 3.95 ± 1.68 mm Hg during TLV. No evidence of fluorothorax or cardiac tamponade was observed in either group. We conclude that TLV does not further impair hemodynamics in piglets with preexisting cardiac dysfunction immediately after CPB.

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Effect of perfluorochemical liquid ventilation on cardiac output and blood pressure variability in neonatal piglets with respiratory insufficiency

Cited by 14 publications

References 67 publications

A prototype of a liquid ventilator using a novel hollow-fiber oxygenator in a rabbit model

A prototype of a liquid ventilator using a novel hollow-fiber oxygenator in a rabbit model

Effect of Repeated Induced Airway Collapse During Total Liquid Ventilation

The Hemodynamic Effect of Total Liquid Ventilation in Piglets With Reduced Cardiac Function After Cardiopulmonary Bypass

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