Effect of Pericytes on Cerebral Microvasculature at Different Time Points of Stroke

Zhong, Danni; Wu, Xin; Xie, Wei; Lin, Xianming

doi:10.1155/2021/5281182

Cited by 10 publications

(8 citation statements)

References 53 publications

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“…Methodological Quality of Studies. The methodological quality of the included studies was assessed using the 10item scale with minor modification [22,23]. The contents of the 10-item scale were as follows: (a) peer-reviewed publications, (b) control temperature, (c) randomization of the experiment, (d) blind methods for model induction, (e) blinded outcome assessments, (f) anesthetics without significant intrinsic cardioprotective effects, (g) appropriate animal models (elderly, diabetic, or hypertensive animals), (h) sample size calculation, (i) compliance with animal welfare regulations, and (j) potential conflict of interest statements.…”

Section: Introductionmentioning

confidence: 99%

[Retracted] Selection of the Male or Female Sex in Chronic Unpredictable Mild Stress‐Induced Animal Models of Depression

Jiang

Lin²,

Guan³

et al. 2022

BioMed Research International

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Depression is a serious public health problem and an important factor leading to disease-related disability. Influenced by many factors, such as psychological, hormonal, and genetic factors, the incidence rate of depression in females is approximately two times that in males. However, in preclinical neuroscience research, the selection of the animals’ sex for use in depression models has been controversial. At present, in most preclinical studies, the animals generally chosen in depression models have been male rodents rather than female rodents. It remains doubtful whether the data obtained from male animals can be generalized to female animals. The performance of female animals in preclinical studies of depression has been inconclusive. Based on a review of a large number of original studies in the PubMed database, it was found that although male rodents are more commonly used in the study of depression, the use of female animals also shows good modeling of depression and has its advantages. The influence of the animals’ sex in the chronic unpredictable mild stress (CUMS) model needs further research.

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Section: Introductionmentioning

confidence: 99%

[Retracted] Selection of the Male or Female Sex in Chronic Unpredictable Mild Stress‐Induced Animal Models of Depression

Jiang

Lin²,

Guan³

et al. 2022

BioMed Research International

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“…Under ischemic and hypoxic conditions, excessive constriction of dysfunctional pericytes reduces erythrocyte flux which, in turn, impairs capillary perfusion. 38 Pericyte dysfunction contributes to the pathogenesis of retinopathy, nephropathy, neuropathy, pancreatic beta cell dysfunction, and peripheral artery disease in patients with DM2. 39,40 It is noteworthy that the DM2-induced concurrent deficiency of capillary flow and enlarged deep brain CP region brain infarction is specific to young adult male mice.…”

Section: Go Red For Womenmentioning

confidence: 99%

Sex Difference in Capillary Reperfusion After Transient Middle Cerebral Artery Occlusion in Diabetic Mice

Zhu

Davis

Allen

et al. 2023

Stroke

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Background: Type 2 diabetes (DM2) exacerbates stroke injury, reduces efficacy of endovascular therapy, and worsens long-term functional outcome. Sex differences exist in stroke incidence, response to therapy, poststroke microvascular dysfunction, and functional recovery. In this study, we tested the hypotheses that poor outcome after stroke in the setting of DM2 is linked to impaired microvascular tissue reperfusion and that male and female DM2 mice exhibit different microvascular reperfusion response after transient middle cerebral artery occlusion (MCAO). Methods: Transient MCAO was induced for 60 minutes using an intraluminal filament in young adult DM2 and nondiabetic control male and female mice. Capillary flux in deep cortical layers was assessed using optical coherence tomography–based optical microangiography (OMAG), and associated regional brain infarct size was evaluated by hematoxylin and eosin staining. Results: Compared to baseline, MCAO reduced absolute capillary red blood cell flux by 84% at 24 hours post-MCAO in male DM2 ( P <0.001) but not male control mice. When normalized to pre-MCAO baseline, red blood cell flux 24 hours after stroke was 64% lower in male DM2 mice than male nondiabetic controls ( P <0.01). In females, MCAO decreased capillary flux by 48% at 24 hours post-MCAO compared with baseline in DM2 ( P <0.05) but not in control mice. Red blood cell flux of female DM2 mice did not differ from that of nondiabetic controls either before or 24 hours after MCAO. Furthermore, normalized capillary flux 24 hours after MCAO failed to differ between female DM2 mice and nondiabetic controls. Concomitantly, male but not female DM2 mice experienced 25% larger infarct in caudate-putamen versus respective nondiabetic controls ( P <0.05). Conclusions: DM2 impairs capillary perfusion and exacerbates ischemic deep brain injury in male but not female young adult mice. Premenopausal females appear to be protected against DM2-related capillary dysfunction and brain injury.

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“…This phenomenon, termed reperfusion no-reflow, is harmful to the recovery of ischemic tissues. However, angiogenesis promotes the accumulation of new neuronal cells in the peri-infarct area and contributes to the repair of brain injury after IS, which is significant for tissue regeneration and provides new entry for blood reflow to the hypoperfusion area ( Di et al, 2021 ). The remodeling of microvascular system after IS includes four stages: proliferation of vascular component cells; recruitment of pericytes; formation, migration, and stabilization of vascular budding; and maturation of blood vessels ( Stapor et al, 2014 ; Yang and Torbey, 2020 ).…”

Section: The Role Of Pericytes In Ischemic Strokementioning

confidence: 99%

The Role of Pericytes in Ischemic Stroke: Fom Cellular Functions to Therapeutic Targets

Zhou

Guo

Zhang

et al. 2022

Front. Mol. Neurosci.

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Ischemic stroke (IS) is a cerebrovascular disease causing high rates of disability and fatality. In recent years, the concept of the neurovascular unit (NVU) has been accepted by an increasing number of researchers and is expected to become a new paradigm for exploring the pathogenesis and treatment of IS. NVUs are composed of neurons, endothelial cells, pericytes, astrocytes, microglia, and the extracellular matrix. As an important part of the NVU, pericytes provide support for other cellular components and perform a variety of functions, including participating in the maintenance of the normal physiological function of the blood–brain barrier, regulating blood flow, and playing a role in inflammation, angiogenesis, and neurogenesis. Therefore, treatment strategies targeting pericyte functions, regulating pericyte epigenetics, and transplanting pericytes warrant exploration. In this review, we describe the reactions of pericytes after IS, summarize the potential therapeutic targets and strategies targeting pericytes for IS, and provide new treatment ideas for ischemic stroke.

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Effect of Pericytes on Cerebral Microvasculature at Different Time Points of Stroke

Cited by 10 publications

References 53 publications

[Retracted] Selection of the Male or Female Sex in Chronic Unpredictable Mild Stress‐Induced Animal Models of Depression

[Retracted] Selection of the Male or Female Sex in Chronic Unpredictable Mild Stress‐Induced Animal Models of Depression

Sex Difference in Capillary Reperfusion After Transient Middle Cerebral Artery Occlusion in Diabetic Mice

The Role of Pericytes in Ischemic Stroke: Fom Cellular Functions to Therapeutic Targets

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