Effect of Perinatal Antiretroviral Drug Exposure on Hematologic Values in HIV‐Uninfected Children: An Analysis of the Women and Infants Transmission Study

Abstract

Infants exposed to ARV drugs have small but significant differences in several hematologic parameters for the first 24 months of life. These results indicate the need for long-term follow-up of uninfected infants with ARV exposure.

Imbalance of naive and memory T lymphocytes with sustained high cellular activation during the first year of life from uninfected children born to HIV-1-infected mothers on HAART

“…Lower hemoglobin levels and neutropenia (12,13) have been shown previously in infants exposed in utero to antiretroviral drugs. In a recent publication, different antiretroviral schemes led to diverse toxic effects (14). In our study, hemoglobin levels Figure 2.…”

High Levels of Zidovudine (AZT) and Its Intracellular Phosphate Metabolites in AZT- and AZT-Lamivudine-Treated Newborns of Human Immunodeficiency Virus-Infected Mothers

“…We chose to focus on hematological parameters and lactates that were systematically collected and analyzed as part of the infants' routine care during the first 6 months of life, as they have been more consistently linked to perinatal drug exposure (40). Severity was graded based on the WHO pediatric classification.…”

Tolérance pour l’enfant des antirétroviraux durant la grossesse

“…Cette atteinte modeste, mais très significative sur le plan statistique, signe une altération des cellules souches hématopoïétiques. Nous avons pu montrer que ces cellules souches CD34 + sont le siège d'altérations fonctionnelles et que leur profil de transcription génique est compatible avec un processus de réparation de l'ADN [30][31][32]. De nouvelles données de notre laboratoire sur le caractère génotoxique de la zidovudine chez l'enfant exposé in utero ne font que renforcer le questionnement de la tolérance à long terme de ce traitement.…”