Effect of periodontal treatment on IL‐1β, IL‐1ra, and IL‐10 levels in gingival crevicular fluid in patients with aggressive periodontitis

Abstract

The periodontal treatment improves the clinical parameters in G-AgP, and this improvement is evident in deep pocket sites for pocket depth and CAL values. These results confirm that IL-1beta is effective for evaluating the periodontal inflammation and can thus be used as a laboratory tool for assessing the activity of periodontal disease.

Immunoassay analysis of proteins in gingival crevicular fluid samples from resorbing teeth

“…5,17 The role of IL-1RA as an important inhibitor of bone remodeling is well documented in the literature, 3,18 and some studies show a positive correlation between decreased levels of IL-1RA in GCF and faster bone resorption in periodontitis and orthodontic tooth movement. 19,20 Our finding seems to support this association: The down-regulation of IL-1RA in the periodontal tissues during tooth eruption could allow for greater mineralized tissue resorption and may help explain the low IL-1RA concentration in the GCF of resorbing teeth.…”

IL-6 and IL-10 gene polymorphisms in patients with aggressive periodontitis: effects on GCF, serum and clinic parameters

“…29 Similarly, these findings were observed in our previous study. 7 In the literature, there are few studies investigating the relationship between AgP and IL-6 gene polymorphisms. 6,20,32,33 Supporting our results, Nibali et alreported that IL-6 GG genotype was associated with susceptibility to AgP.5 Similarly, ameta-analysis indicated that the IL-6(-174) G allele did not modify the risk of CP, but increased the risk of AgP.…”

“…6,7 Also, cytokine expressions a re a ffected by t he presence of f u nct ional gene polymorphisms. 6 Interleukin (IL)-6 is a pleiotropic cytokine released by many cell types, and its secretion levels are determined by the producing cell type and the genetic background of the source cells.…”

Decreased Ratios of Interleukin-1<i>β</i> and Intercellular Adhesion Molecule 1 in Gingival Crevicular Fluid after Scaling and Root Planing Associated with Periodontal Pocket Healing

“…Several researchers have investigated the relationship between clinical parameters and the levels of inflammatory cytokines such as IL-1β and IL-8 after SRP. Toker et al found that there were no significant correlations between the level of IL-1β and clinical parameters 6 weeks after initial periodontal therapy [33]. Research by Gamonal et al also showed a very weak correlation between clinical parameters and the levels of IL-1β and IL-8 2 months after SRP [34].…”