Effect of Periodontitis on Adiponectin, C‐Reactive Protein, and Immunoglobulin G Against Porphyromonas gingivalis in Thai People With Overweight or Obese Status

Abstract

Periodontitis and overweight or obese BMI change plasma levels of the inflammatory mediators adiponectin and CRP, independently. This study suggests a role of periodontitis in systemic inflammatory response in Thai people who are overweight or obese.

Influence of periodontitis and scaling and root planing on insulin resistance and hepatic CD36 in obese rats

“…Both obesity and periodontitis can stimulate the up‐regulation of several inflammation factors, such as TNF‐α, IL‐6, and CRP . Periodontitis is a chronic low‐grade inflammatory disease caused by periodontal destructions over time .…”

“…Both obesity and periodontitis can stimulate the upregulation of several inflammation factors, such as TNF-, IL-6, and CRP. 27 Periodontitis is a chronic low-grade inflammatory disease caused by periodontal destructions over time. 11 In this study, periodontal attachment level and HE staining of teeth showed that experimental periodontitis caused significant attachment loss and alveolar bone destruction.…”

Peri‐implant parameters and C‐reactive protein levels among patients with different obesity levels

“…A systemic proinflammatory state in obesity is suggested for increased alveolar bone loss with altered immune response because of compromised functional state of immune cells . C‐reactive protein (CRP) in particular, is a marker of systemic inflammation and is associated with obesity and periodontitis . Elevated levels of CRP is characterized by dysregulated and increased production of several proinflammatory cytokines that are implicated in the pathogenesis of periodontal destruction …”

“…9 C-reactive protein (CRP) in particular, is a marker of systemic inflammation and is associated with obesity and periodontitis. 10 Elevated levels of CRP is characterized by dysregulated and increased production of several proinflammatory cytokines that are implicated in the pathogenesis of periodontal destruction. 9,11,12 In the past decade, obesity has been thoroughly investigated as one of the risk factors for periodontal tissue destruction and association between increased adiposity and poor periodontal outcomes is well elucidated; [13][14][15][16] In a recent cross-sectional study by Abduljabbar and colleagues, 17 it was concluded that obese individuals showed increased peri-implant probing depth (PD) and higher amount of marginal bone loss (MBL) as compared to nonobese individuals.…”

Increased oral inflammation, leukocytes, and leptin, and lower adiponectin in overweight or obesity

“…Poor oral health promotes obesity, obesity impacts on oral inflammation, or the relationship may be a combination of both mechanisms. The increased serum inflammatory markers from both diseases suggest that systemic inflammation plays a key role in the process (Pischon et al., ; Thanakun & Izumi, ).…”