Effect of peritoneal dialysis on antioxidant defense system and oxidative stress

Montazerifar, Farzaneh; Karajibani, Mansour; Sanadgol, Houshang; Hashemi, Mohammad

doi:10.1016/j.hkjn.2012.09.004

Cited by 5 publications

(5 citation statements)

References 23 publications

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“…Higher levels of MDA have been reported in patients with ESRD, HD, PD vs. HC (45, 46). There are also reports where no differences in MDA levels in patients with PD and HC (47). In our study, we found increased levels of LPO in all types of PT (48) and no correlation with the value of PET.…”

Section: Discussionmentioning

confidence: 98%

The Behavior of the Type of Peritoneal Transport in the Inflammatory and Oxidative Status in Adults Under Peritoneal Dialysis

et al. 2019

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Peritoneal dialysis (PD) is an alternative for managing the end-stage renal disease (ESRD). The peritoneal membrane (PM) is not just a membrane that passively responds to diffusion and convection. The characteristics of PM result in the peritoneal equilibrium test (PET) and with this test is possible to obtain the type of peritoneal transport (PT). The patient on PD can be classified in different types of PT as; Low, Low Average, High Average, and High. The aim of the study was to compare the inflammatory cytokines, oxidants, antioxidants, and oxidative DNA damage markers in the different types of PT. A cross-sectional analytical study of 77 adult PD patients was performed. Levels of lipoperoxides (LPO) were higher in all types of PT vs. healthy volunteer controls (HC) (p < 0.0001). Nitric oxide (NO) levels were found significantly down-regulated in all types of PT (p < 0.0001). The activity of the superoxide dismutase enzyme (SOD) was found to be significantly increased in all types of PT vs. the HC (p < 0.0001). The levels of the DNA repair enzyme were found to be decreased in all types of PT. The levels of the pro-inflammatory cytokines TNF-α, IL-6, the marker of oxidative DNA damage, 8-IP and the total antioxidant capacity (TAC) were all significantly decreased, contrary to the levels in HC, possibly by the clearance in the dialysis fluid in all types of PT or due to down-regulation of their expression. In conclusion, we found significant changes in markers of inflammation, oxidative stress, and oxidative damage to DNA in all types of PT; Low, low average, high average, and high PT in the values of D/P creatinine at 4 h compared to HC.

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Section: Discussionmentioning

confidence: 98%

The Behavior of the Type of Peritoneal Transport in the Inflammatory and Oxidative Status in Adults Under Peritoneal Dialysis

et al. 2019

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“…It is of importance to note that our findings are in accordance with the report by Montazerifar et al . [17] The authors showed that decreased activity of enzymatic antioxidant defense system played a leading role in accelerated atherogenesis in PD patients.…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress in peritoneal dialysis patients: Association with the dialysis adequacy and technique survival

2019

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Introduction:Increased oxidative stress is suggested as one of the possible mechanisms of structural and functional damage to the peritoneal membrane in peritoneal dialysis patients. But there are few available data on the association of oxidative stress with peritoneal dialysis adequacy and technique survival. The present study was undertaken to investigate the association of oxidative stress biomarkers with the peritoneal dialysis adequacy and technique survival.Methods:This prospective single-center observational study was conducted between January 2010 and May 2015. Adequacy of dialysis, malondialdehyde levels in the serum and erythrocytes (as an indicator of lipid peroxidation), the concentration of ceruloplasmin, transferrin, and sulfhydryl groups in the blood, and total peroxidase activity in erythrocyte (as indicators of antioxidant system) were determined in 44 stable ambulatory non-diabetic peritoneal dialysis patients.Results:The follow-up period was 3 years. We identified a negative correlation between the serum level of malondialdehyde in the patients and total weekly Kt/V. Peritoneal weekly CrCl was positively correlated with the levels of transferrin, total peroxidase activity, and SH– groups. Daily peritoneal ultrafiltration had a positive correlation with the total peroxidase activity and the serum transferrin levels. The results of the Kaplan–Meier analysis and the log-rank test also demonstrated a significant difference in the cumulative technique survival rate between the patients with ceruloplasmin level ≤0.19 g/l and ≥0.2 g/l.Conclusions:The results mentioned above could be considered as one of the ways to explain better technique survival in PD patients.

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“…In patients with chronic kidney disease (CKD), structural damage and kidney dysfunction occur, this can trigger the emergence of oxidative stress caused by increased oxidant activity and decreased antioxidant systems which will later have an impact on the TAC (Putri & Thaha, 2014). A Journal homepage: https://e-journal.unair.ac.id/MBIO/ number of studies have reported TAC levels of CKD patients who undergo hemodialysis (HD) and nonhemodialysis (non-HD) that are quite varied and controversial (Mayer et al, 2003;Montazerifar et al, 2012). In addition, in Indonesia, especially in Surabaya, there is still no data on TAC CKD patients who undergo HD and non-HD.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Total Antioxidant Capacity (Tac)’s Patients of Chronic Kidney Disease Undergoing Hemodialysis and Non-Hemodialysis

El-Hakim

Thaha

Hernaningsih

2020

MBiom

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Background: Total antioxidant capacity (TAC) is one of the biomarkers to determine a person's health condition through antioxidant and oxidant activity or oxidative stress so that it can help in determining the therapy needed. However, currently, TAC levels in patients with chronic kidney disease (CKD) undergoing hemodialysis (HD) and non-hemodialysis (non-HD) are still controversial, so further research is needed. Objective: To analyze the comparison of TAC in HD and non-HD CKD patient. Material and Method: This was an analytical cross-sectional study with clinical observation in CKD patient. A total of 71 CKD patients consisting of 28 CKD HD patients and 43 non-HD CKD patients were enrolled in this study. Data about the characteristics of the subjects were taken using the anamnesis method, while data about TAC were taken using the colorimetric method with COBAS C-501 0837-19 series and 0835-13 series to measure TAC levels in the serum of CKD patients. The data that has been obtained were analyzed using independent sample t-tests. Result: TAC levels were significantly higher in CKD patients undergoing HD compared to non-HD CKD patients (p <0.05). There are data on albumin as an antioxidant and MDA as an oxidative stress biomarker that affects TAC levels. Conclusion: TAC levels found to be higher in hemodialysis CKD patient compared to non-hemodialysis CKD patient.

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Effect of peritoneal dialysis on antioxidant defense system and oxidative stress

Cited by 5 publications

References 23 publications

The Behavior of the Type of Peritoneal Transport in the Inflammatory and Oxidative Status in Adults Under Peritoneal Dialysis

The Behavior of the Type of Peritoneal Transport in the Inflammatory and Oxidative Status in Adults Under Peritoneal Dialysis

Oxidative stress in peritoneal dialysis patients: Association with the dialysis adequacy and technique survival

Comparison of Total Antioxidant Capacity (Tac)’s Patients of Chronic Kidney Disease Undergoing Hemodialysis and Non-Hemodialysis

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