Effect of Persistent Sodium Current on Neuronal Activity

Smirnova, Elena Y.; Zefirov, Artyom V.; Amakhin, Dmitry V.; Chizhov, Anton V.

doi:10.1007/978-3-319-66604-4_28

Cited by 1 publication

(2 citation statements)

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“…As a result, I NaP amplifies both excitability and inhibition in neurons [ 111 , 112 ]. Basic neurophysiology studies have indicated that abnormally elevated I NaP contributes to neuronal hyperexcitability [ 113 ]. Increased I NaP has been found in neurons of different epilepsy models [ 59 , 114 , 115 ].…”

Section: Polyamines and Pathological Changes In Epilepsymentioning

confidence: 99%

“…Most antiepileptic drugs acting on VGSCs voltage-dependently inhibit I NaT to suppress neuronal excitability but have no effects on I NaP . As an abnormal I NaP has been considered a key pathogenic factor, inhibition of I NaP may be a potential therapeutic target for epilepsy [ 113 , 118 , 119 , 120 ]. Du et al [ 121 ] found that reduced I NaP suppressed the seizures caused by mutations affecting axonal K(v)1 channels, confirming an antiepileptic effect of I NaP blockade.…”

Section: Polyamines and Pathological Changes In Epilepsymentioning

confidence: 99%

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The Potential Role of Polyamines in Epilepsy and Epilepsy-Related Pathophysiological Changes

Liu

Maimaiti

et al. 2022

Biomolecules

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Epilepsy is one of the most common neurological disorders and severely impacts the life quality of patients. Polyamines are ubiquitous, positively charged aliphatic amines that are present at a relatively high level and help regulate the maintenance of cell membrane excitability and neuronal physiological functions in the central nervous system. Studies have shown abnormalities in the synthesis and catabolism of polyamines in patients with epilepsy and in animal models of epilepsy. The polyamine system seems to involve in the pathophysiological processes of epilepsy via several mechanisms such as the regulation of ion permeability via interaction with ion channels, involvement in antioxidation as hydroperoxide scavengers, and the induction of cell damage via the production of toxic metabolites. In this review, we try to describe the possible associations between polyamines and epilepsy and speculate that the polyamine system is a potential target for the development of novel strategies for epilepsy treatment.

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