Effect of Personal Exposure to PM2.5 on Respiratory Health in a Mexican Panel of Patients with COPD

Cortez‐Lugo, Marlene; Ramírez-Aguilar, Matiana; Pérez‐Padilla, Rogelio; Sansores-Martínez, Raúl; Ramírez‐Venegas, Alejandra; Barraza‐Villarreal, Albino

doi:10.3390/ijerph120910635

Cited by 60 publications

(28 citation statements)

References 45 publications

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“…These results are close to the study conducted by Chattopadhyay BP et al, who found that the impaired pulmonary function was associated with exposure to automobile exhaust, especially, 30.4% at risk of developing the restrictive syndrome for conductors and 28.9% for drivers [ 30 ]. Similar results in the decrease of pulmonary function associated to traffic-related air pollution were reported in Mexican, Indian and in Danish studies [ 31 – 33 ].…”

Section: Discussionsupporting

confidence: 88%

Occupation exposed to road-traffic emissions and respiratory health among Congolese transit workers, particularly bus conductors, in Kinshasa: a cross-sectional study

Mbelambela

Hirota

Eitoku

et al. 2017

Environ Health Prev Med

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ObjectivesRoad-traffic emissions (RTE) induce adverse health effects, notably respiratory symptoms and respiratory diseases, as a result of pollutants deposited into the respiratory tract. The aim of this study was to evaluate the association between occupation groups of Congolese transit workers exposed to RTE, particularly bus conductors and respiratory health, in Kinshasa.MethodsA cross-sectional study was conducted from 2015 April 20th to May 14th, whose participants were bus conductors (n = 110), bus drivers (n = 107), taxi-motorcyclists (n = 102) and high school teachers (control group; n = 106). Subjects had completed the American Thoracic Society respiratory symptom questionnaire. Lung function test was performed by spirometry. Air pollutants levels of PM2.5, NO2 and SO2 were measured between 7:30 and 8:30 and 16:30–17:30 using a portable gas monitor.Multivariate analysis was performed to evaluate the association between occupation exposed to RTE and impaired pulmonary function, after adjustment by plausible confounders.ResultsThe prevalence of mixed syndrome was 21.9% for bus conductors, 10.9% for bus drivers, 15.4% for taxi-motorcyclists and 7.1% for high school teachers with (p < 0.05). The risk of developing a mixed syndrome was seven times higher among bus conductors [OR = 7.64; 95% CI: 1.83–31.67; p < 0.05] than other groups. Additionally, the prevalence of respiratory syndromes increased with the duration of exposure.ConclusionsOccupation exposed to RTE is associated with impaired pulmonary function and the prevalence of respiratory symptoms among transit workers, especially bus conductors. Furthermore, this association increases with the duration of exposure suggesting the necessity to regulate these categories of occupations and to apply preventives measures.

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Section: Discussionsupporting

confidence: 88%

Occupation exposed to road-traffic emissions and respiratory health among Congolese transit workers, particularly bus conductors, in Kinshasa: a cross-sectional study

Mbelambela

Hirota

Eitoku

et al. 2017

Environ Health Prev Med

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“…5). Nevertheless, the impact of BC on S. pneumoniae colonisation may explain why exposure to PM is associated with bacterial pneumonia (Brugha and Grigg, 2014;MacIntyre et al, 2014;Qiu et al, 2014) and exacerbation of chronic infectious diseases such as asthma and COPD (Cortez-Lugo et al, 2015;Deng et al, 2015;Xu et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Air pollution alters Staphylococcus aureus and Streptococcus pneumoniae biofilms, antibiotic tolerance and colonisation

Hussey

Purves

Allcock

et al. 2017

Environmental Microbiology

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SummaryAir pollution is the world's largest single environmental health risk (WHO). Particulate matter such as black carbon is one of the main components of air pollution. The effects of particulate matter on human health are well established however the effects on bacteria, organisms central to ecosystems in humans and in the natural environment, are poorly understood. We report here for the first time that black carbon drastically changes the development of bacterial biofilms, key aspects of bacterial colonisation and survival. Our data show that exposure to black carbon induces structural, compositional and functional changes in the biofilms of both S. pneumoniae and S. aureus. Importantly, the tolerance of the biofilms to multiple antibiotics and proteolytic degradation is significantly affected. Additionally, our results show that black carbon impacts bacterial colonisation in vivo. In a mouse nasopharyngeal colonisation model, black carbon caused S. pneumoniae to spread from the nasopharynx to the lungs, which is essential for subsequent infection. Therefore our study highlights that air pollution has a significant effect on bacteria that has been largely overlooked. Consequently these findings have important implications concerning the impact of air pollution on human health and bacterial ecosystems worldwide.

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“…Having Amerindian genes is more commonly associated with COPD-BS and that may be linked with genetic susceptibility, contrasting with increased exposure to particulate matter in tobacco smokers and also with more exposure to air pollution in the city, which could influence our results. Moreover, usually there is more intense exposure to PM2.5 in tobacco smokers compared to individuals exposed to biomass smoke COPD [29]. The composition of tobacco biomass and wood or fuel biomass may explain differences in the presentation of both forms of COPD [2][3][4]6,25].…”

Section: Discussionmentioning

confidence: 99%

Participation of the miR-22-HDAC4-DLCO Axis in Patients with COPD by Tobacco and Biomass

et al. 2019

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Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation and systemic inflammation. The main causes of COPD include interaction between genetic and environmental factors associated with tobacco smoking (COPD-TS) and/or exposure to biomass smoke (COPD-BS). Several microRNAs (miRNAs) control posttranscriptional regulation of COPD-TS associated gene expression. The miR-22-HDAC4-IL-17 axis was recently characterized. It is still unknown, however, whether this axis, participates in COPD-BS. To investigate, 50 patients diagnosed with severe-to-very severe COPD GOLD (Global Initiative for Chronic Obstructive Lung Disease) stages III/IV, were recruited, 25 women had COPD-BS (never smokers, exposed heavily to BS) and 25 had COPD-TS. Serum levels of miRNA-22-3p were measured by RT (Reverse Transcription)-qPCR, while the concentration of HDAC4 (Histone deacetylase 4) was detected by ELISA. Additionally, we looked for association between serum HDAC4 and DLCOsb (Single-breath diffusing capacity of the lung for carbon monoxide), as % of predicted by age, height, and gender, one of the main differences described between COPD-BS and COPD-TS. Women with COPD-BS were older and shorter and had a higher DLCOsb %P (percent predicted) compared to COPD-TS. Serum miR-22-3p was downregulated in COPD-BS relative to COPD-TS. In contrast, the concentration of HDAC4 was higher in COPD-BS compared to COPD-TS. Furthermore, a positive correlation between serum HDAC4 levels and DLCOsb %P was observed. We concluded that the miR-22-HDAC4-DLCO axis behaves differently in patients with COPD-BS and COPD-TS.

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Effect of Personal Exposure to PM2.5 on Respiratory Health in a Mexican Panel of Patients with COPD

Cited by 60 publications

References 45 publications

Occupation exposed to road-traffic emissions and respiratory health among Congolese transit workers, particularly bus conductors, in Kinshasa: a cross-sectional study

Occupation exposed to road-traffic emissions and respiratory health among Congolese transit workers, particularly bus conductors, in Kinshasa: a cross-sectional study

Air pollution alters Staphylococcus aureus and Streptococcus pneumoniae biofilms, antibiotic tolerance and colonisation

Participation of the miR-22-HDAC4-DLCO Axis in Patients with COPD by Tobacco and Biomass

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