Effect of pH and ionic strength on the reactivity of Bioglass® 45S5

Cerruti, Marta; Greenspan, David C.; Powers, Kevin

doi:10.1016/j.biomaterials.2004.07.009

Cited by 275 publications

(268 citation statements)

References 35 publications

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“…EDX confirms the relative oxide contribution to each composition and correlates to the calculated compositions. Regarding glass leaching, the observed increase in pH is similar to that observed in typical bioactive glasses [36], where the Con glass saw the greatest rise from 11.9 after 1 day to 12.4 after 30 days thus it can be assumed that there is a direct relationship between the increase in pH and the dissolution of the glass network. This can be related to the initial exchange of hydrogen ions (H + ) with Na + where this attack is most pronounced in the Con glass with the highest Na content.…”

Section: Discussionsupporting

confidence: 79%

Investigating the Effect of Glass Ion Release on the Cytocompatibility, Antibacterial Eflcacy and Antioxidant Activity of Y2O3 / CeO2 doped SiO2-SrO-Na2O glasses

et al. 2018

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Abstract:The effect on ion release and cytocompatibility of Yttrium (Y) and Cerium (Ce) are investigated when substituted for Sodium (Na) in a 0.52SiO 2 -0.24SrO-0.24-Na 2 O-MO glass series (where MO = Y 2 O 3 or CeO 2 ). Glass leaching was evaluated through pH measurements and Inductive Coupled Plasma-Optical Emission Spectrometry (ICP-OES) analysis where the extract pH increased during incubation (11.2 -12.5). Ion release of Silicon (Si), Na and Strontium (Sr) from the Con glass was at higher than that of glasses containing Y or Ce, and reached a limit after 1 day. Ion release from Y and Ce containing glasses reached a maximum of 1800 µg/mL, 1800 µg/mL, and 10 µg/mL for Si, Na, and Sr, respectively. Release of Y and Ce was below the ICP-OES detection limit <0.1 µg/mL. Cell viability of both L929 fibroblasts and MC3T3 osteoblasts decreased for Con, LY, and LCe extracts; HY extracts did not significantly decrease cell viability while YCe and HCe saw concentrationdependent viability decrease (20%, 33% extract concentrations). Bacterial studies saw Con and LCe eliminating >75% of bacteria at a 9% extract concentration. Antioxidant capacity (mechanism for neuroprotection) was evaluated using the ABTS assay. All glasses had inherent radical oxygen species (ROS) scavenging capability with Con reaching 9.5 mMTE.

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Section: Discussionsupporting

confidence: 79%

Investigating the Effect of Glass Ion Release on the Cytocompatibility, Antibacterial Eflcacy and Antioxidant Activity of Y2O3 / CeO2 doped SiO2-SrO-Na2O glasses

et al. 2018

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“…1a. The peak located around 932 cm -1 (unary film), attributed to the stretching vibrations of SiOH or SiO -groups 26,33,34 , shifted toward a large wavenumber (~938 cm -1 ) in the ternary film; its intensity, however, decreased. It is important to recognize that the peak of around 1238 cm -1 , which has been attributed to the corresponding longitudinal optical (LO) vibration mode of the Si-O-Si linkage 24,35 in Figure 1, has the highest intensity, because of the large angle of incidence used, which is in accordance with that reported in prior literature 24 .…”

Section: Methodsmentioning

confidence: 96%

“…For the ternary films the bands at the 900-1200 cm -1 range were attributed to the Si-O and P-O stretching vibrations. Literature shows that there is a superposition of bands located close to one another 34,36 . As can be seen in Figure 2, when a small incident angle (25°) was used in the FTIR experiment, the peak located around 1230 cm -1 diminished its intensity, which supports that reported in the literature for all three spectra 23 .…”

Section: Methodsmentioning

confidence: 99%

Sol-Gel SiO2-CaO-P2O5 biofilm with surface engineered for medical application

et al. 2007

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Sol-gel film in the SiO 2 -CaO-P 2 O 5 system was prepared from TEOS, TEP, alcohol and hydrated calcium nitrate in an acidic medium. The coatings were deposited on stainless steel using the dip-coating technique. After deposition, the composite was submitted to heat treatment, at different temperatures and exposure times to investigate the influence of such parameters on the surface morphology of the composite. The coated surfaces were characterized by AFM, SEM and FTIR. The present study showed that the formation of different textures (an important parameter in implant fixation) could be controlled by temperature and time of heat treatment.

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“…Capillary tube formation on Matrigel was observed at the end under an inverted Leica DMIL microscope and photos were taken using the Leica application suite software (Leica GmbH, Wetzlar, Germany). O-Si of the SiO 4 tetrahedra, respectively [69], the peak at around 900 cm 21 can be assigned to the SiO NBO (non-bonding oxygen, NBO) [27] and the band that can be observed at 1450 cm 21 would be attributed to the carbonates that are adsorbed on the surface [27,70]. FTIR spectra of cross-linked composite 2D scaffolds showed intense bands from both the Alg and Nbg, and a slight shift in almost all the absorption bands was observed when compared with the Alg spectrum, where narrower intensity bands for OH and COO groups are seen in the spectra of AlgNbgCu and AlgNbgCa.…”

Section: Matrigel Two-dimensional Assaymentioning

confidence: 99%

Novel nanocomposite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds

Cattalini

Hoppe

Pishbin

et al. 2015

J. R. Soc. Interface.

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This work aimed to develop novel composite biomaterials for bone tissue engineering (BTE) made of bioactive glass nanoparticles (Nbg) and alginate cross-linked with Cu 2þ or Ca 2þ (AlgNbgCu, AlgNbgCa, respectively). Twodimensional scaffolds were prepared and the nanocomposite biomaterials were characterized in terms of morphology, mechanical strength, bioactivity, biodegradability, swelling capacity, release profile of the cross-linking cations and angiogenic properties. It was found that both Cu 2þ and Ca 2þ are released in a controlled and sustained manner with no burst release observed. Finally, in vitro results indicated that the bioactive ions released from both nanocomposite biomaterials were able to stimulate the differentiation of rat bone marrow-derived mesenchymal stem cells towards the osteogenic lineage. In addition, the typical endothelial cell property of forming tubes in Matrigel was observed for human umbilical vein endothelial cells when in contact with the novel biomaterials, particularly AlgNbgCu, which indicates their angiogenic properties. Hence, novel nanocomposite biomaterials made of Nbg and alginate cross-linked with Cu 2þ or Ca 2þ were developed with potential applications for preparation of multifunctional scaffolds for BTE.

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Effect of pH and ionic strength on the reactivity of Bioglass® 45S5

Cited by 275 publications

References 35 publications

Investigating the Effect of Glass Ion Release on the Cytocompatibility, Antibacterial Eflcacy and Antioxidant Activity of Y2O3 / CeO2 doped SiO2-SrO-Na2O glasses

Investigating the Effect of Glass Ion Release on the Cytocompatibility, Antibacterial Eflcacy and Antioxidant Activity of Y2O3 / CeO2 doped SiO2-SrO-Na2O glasses

Sol-Gel SiO2-CaO-P2O5 biofilm with surface engineered for medical application

Novel nanocomposite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds

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