Novel nanocomposite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds

Cattalini, Juan Pablo; Hoppe, Alexander; Pishbin, F.; Roether, Judith A.; Boccaccını, Aldo R.; Lucangioli, Silvia; Mouriño, Viviana

doi:10.1098/rsif.2015.0509

Cited by 35 publications

(22 citation statements)

References 79 publications

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“…They found that the controlled delivery of Cu ions from borate bioactive glass implants is a promising approach for the healing of bone defects. More studies to utilize nanotechnology to fabricate Cu-containing materials indicated basically similar results that Cu 2+ could promote osteoblast proliferation and accelerate bone fracture healing [ [82] , [83] , [84] , [85] ]. Li et al found that at a concentration of 10 μM lower, Cu 2+ was safe for mouse osteoblastic cell line (MC3T3-E1) and beneficial for its proliferation in a dose-dependent manner.…”

Section: Cu-containing Materials Promoting Bone Fracture Healingmentioning

confidence: 99%

Biological applications of copper-containing materials

Wang

Yuan

et al. 2021

Bioactive Materials

122

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Copper is an indispensable trace metal element in the human body, which is mainly absorbed in the stomach and small intestine and excreted into the bile. Copper is an important component and catalytic agent of many enzymes and proteins in the body, so it can influence human health through multiple mechanisms. Based on the biological functions and benefits of copper, an increasing number of researchers in the field of biomaterials have focused on developing novel copper-containing biomaterials, which exhibit unique properties in protecting the cardiovascular system, promoting bone fracture healing, and exerting antibacterial effects. Copper can also be used in promoting incisional wounds healing, killing cancer cells, Positron Emission Tomography (PET) imaging, radioimmunological tracing and radiotherapy of cancer. In the present review, the biological functions of copper in the human body are presented, along with an overview of recent progress in our understanding of the biological applications and development of copper-containing materials. Furthermore, this review also provides the prospective on the challenges of those novel biomaterials for future clinical applications.

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Section: Cu-containing Materials Promoting Bone Fracture Healingmentioning

confidence: 99%

Biological applications of copper-containing materials

Wang

Yuan

et al. 2021

Bioactive Materials

122

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“…Together, the different metal ions have functional roles in the physiological cellular environment as well as in the course of bone healing. Thus, the application of metal ions in combination with the above-mentioned bone substitutes or singularly, is of special interest for bone regeneration [ 46 , 47 , 48 ]. To provide an overview of the regenerative potential of the different metal ions, the present review summarizes the knowledge about their involvement in cellular processes and the bone healing process, with a further focus on studies that have already analyzed the regenerative potential of bone substitutes, including metals.…”

Section: Introductionmentioning

confidence: 99%

Applications of Metals for Bone Regeneration

Glenske

Donkiewicz²,

Köwitsch³

et al. 2018

IJMS

180

125

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The regeneration of bone tissue is the main purpose of most therapies in dental medicine. For bone regeneration, calcium phosphate (CaP)-based substitute materials based on natural (allo- and xenografts) and synthetic origins (alloplastic materials) are applied for guiding the regeneration processes. The optimal bone substitute has to act as a substrate for bone ingrowth into a defect, as well as resorb in the time frame needed for complete regeneration up to the condition of restitution ad integrum. In this context, the modes of action of CaP-based substitute materials have been frequently investigated, where it has been shown that such materials strongly influence regenerative processes such as osteoblast growth or differentiation and also osteoclastic resorption due to different physicochemical properties of the materials. However, the material characteristics needed for the required ratio between new bone tissue formation and material degradation has not been found, until now. The addition of different substances such as collagen or growth factors and also of different cell types has already been tested but did not allow for sufficient or prompt application. Moreover, metals or metal ions are used differently as a basis or as supplement for different materials in the field of bone regeneration. Moreover, it has already been shown that different metal ions are integral components of bone tissue, playing functional roles in the physiological cellular environment as well as in the course of bone healing. The present review focuses on frequently used metals as integral parts of materials designed for bone regeneration, with the aim to provide an overview of currently existing knowledge about the effects of metals in the field of bone regeneration.

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“…Copper-containing biomaterials, both for hard and soft tissues, have drawn the attention of researchers [ 10 , 11 , 12 , 13 , 14 , 15 ] due to the angiogenetic and antimicrobial properties of copper [ 8 , 9 , 10 , 15 , 16 , 17 ]. The ability to modify the composition of bioactive glasses by introducing therapeutic ions has been exploited to create copper-containing bioactive devices [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Copper-Doped Bioactive Glass as Filler for PMMA-Based Bone Cements: Morphological, Mechanical, Reactivity, and Preliminary Antibacterial Characterization

et al. 2018

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To promote osteointegration and simultaneously limit bacterial contamination without using antibiotics, we designed innovative composite cements containing copper (Cu)-doped bioactive glass powders. Cu-doped glass powders were produced by a melt and quenching process, followed by an ion-exchange process in a Cu salt aqueous solution. Cu-doped glass was incorporated into commercial polymethyl methacrylate (PMMA)-based cements with different viscosities. The realized composites were characterized in terms of morphology, composition, leaching ability, bioactivity, mechanical, and antibacterial properties. Glass powders appeared well distributed and exposed on the PMMA surface. Composite cements showed good bioactivity, evidencing hydroxyapatite precipitation on the sample surfaces after seven days of immersion in simulated body fluid. The leaching test demonstrated that composite cements released a significant amount of copper, with a noticeable antibacterial effect toward Staphylococcus epidermidis strain. Thus, the proposed materials represent an innovative and multifunctional tool for orthopedic prostheses fixation, temporary prostheses, and spinal surgery.

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Novel nanocomposite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds

Cited by 35 publications

References 79 publications

Biological applications of copper-containing materials

Biological applications of copper-containing materials

Applications of Metals for Bone Regeneration

Copper-Doped Bioactive Glass as Filler for PMMA-Based Bone Cements: Morphological, Mechanical, Reactivity, and Preliminary Antibacterial Characterization

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