Effect of pH and TPP concentration on chemico-physical properties, release kinetics and antifungal activity of Chitosan-TPP-Ungeremine microbeads

Moeini, Arash; Cimmino, Alessio; Poggetto, Giovanni Dal; Biase, Mariaelena Di; Evidente, Antonio; Lavermicocca, Paola; Valerio, Francesca; Leone, Antonella; Santagata, Gabriella; Malinconico, Mario

doi:10.1016/j.carbpol.2018.05.005

Cited by 67 publications

(27 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To date, there have been few reports on the ability of intrafibrillar remineralization of dentin. Recent studies have indicated that sodium tripolyphosphate (TPP) may be used as a biomimetic analog of dentin matrix protein 1 (DMP1) and as a non-collagen protein in dentin to induce specific binding to collagen microfibrils [21,22]. Although TPP has been frequently employed as an additive in the food industry, it can also phosphorylate dentin collagen [23].…”

mentioning

confidence: 99%

Remineralization of dentin slices using casein phosphopeptide–amorphous calcium phosphate combined with sodium tripolyphosphate

Zhou

Bian

et al. 2020

BioMed Eng OnLine

View full text Add to dashboard Cite

Background Dentin hypersensitivity is a commonly found symptom in stomatology and it is usually caused by loss of enamel and demineralization of dentin leading to symptoms of sore teeth following dentin irritation [1]. The worldwide prevalence of dentin hypersensitivity ranges from 8 to 74% worldwide [2-4]. Dentin hypersensitivity can be treated with nerve stabilization or with potassium and dental laser irradiation

show abstract

mentioning

confidence: 99%

Remineralization of dentin slices using casein phosphopeptide–amorphous calcium phosphate combined with sodium tripolyphosphate

Zhou

Bian

et al. 2020

BioMed Eng OnLine

View full text Add to dashboard Cite

show abstract

“…It can be hypothesized that at a basic pH (more OH − ions), there will be a competition for cross-linking between OH − ions and TPP P 3 O 10 5− ions with the NH 3 + group of chitosan, while at an acidic pH (more H + ions), there will be a strong interaction between the P 3 O 10 5− and NH 3 + groups. Hence, more spherical, smaller, stable and homogeneous beads are formed [32,33]. Consequently, ionotropic gelation technique was selected for the development of nitazoxanide-loaded chitosan microbeads.…”

Section: Preformulation Studiesmentioning

confidence: 99%

Development of nitazoxanide-loaded colon-targeted formulation for intestinal parasitic infections: centre composite design-based optimization and characterization

Bharti¹,

Nagaich

Pandey

et al. 2020

Futur J Pharm Sci

View full text Add to dashboard Cite

Background The current investigation is focused on the development and characterization of Eudragit S100 coated nitazoxanide-loaded microbeads as colon-targeted system utilizing central composite design (CCD) and desirability function. The study initiated with the selection of a BCS class II drug nitazoxanide and its preformulation screening with excipients, selection of polymer and identification of concentration for CCD, selection of optimized formulation based on desirability function, and in vitro release studies in simulated gastric and colonic media and stability studies. A two-factor, three-level CCD was employed with two independent variables, i.e. X1 (chitosan % w/v) and X2 (sodium tripolyphosphate % w/v), and three dependent variables, i.e. Y1 (particle size in micrometres), Y2 (percentage yield) and Y3 (percent entrapment efficiency), were chosen. Additionally, surface morphology, mucoadhesion and in vitro drug release studies were also conducted. Result Chitosan concentration showing maximum entrapment and optimum particle size was selected to formulate chitosan beads. The polynomial equation and model graphs obtained from the Design-Expert were utilized to examine the effect of independent variables on responses. The effect of formulation composition was found to be significant (p ˂ 0.05). Based on the desirability function, the optimized formulation was found to have 910.14 μm ± 1.03 particle size, 91.84% ± 0.64 percentage yield and 84.75% ± 0.38 entrapment efficiency with a desirability of 0.961. Furthermore, the formulations were characterized for in vitro drug release in simulated colonic media (2% rat caecal content) and have shown a sustained release of ∼ 92% up to 24 h as compared to in vitro release in simulated gastric fluid. Conclusion The possibility of formulation in enhancing percentage yield and entrapment efficiency of nitazoxanide and the utilization of CCD helps to effectively integrate nitazoxanide microbeads into a potential pharmaceutical dosage form for sustained release.

show abstract

“…Cerca De acordo com os resultados apresentados na Tabela 2 e na Figura 1 o diâmetro médio, o volume e a superfície das esferas produzidas diminuíram conforme a redução do pH, como também foram geradas distribuições de tamanho mais estreitas. Moeini et al (2018) investigaram em seu trabalho a influência do pH na solução reticulante de TPP e constataram que, ao adicionar ácido acético à solução de TPP, o pH foi reduzido, passando por pH = 7 até pH = 6,1. A concentração de íons hidroxila foi drasticamente reduzida e um mecanismo de cura in-liquid ocorreu, envolvendo a protonação dos grupos amina da quitosana, a repulsão de carga positiva forte e o processo de reticulação iônica entre os grupos P 3 O 10 5e NH 3+ .…”

Section: Caracterizaçõesunclassified

Efeito Imediato Da Auriculoterapia Na Melhora Da Dor E Insônia Em Paciente Com Diagnóstico De Linfoma Não Hodgkin: Um Relato De Caso

Santos¹,

Garcia²,

Souza³

et al. 2019

A Produção Do Conhecimento Nas Ciências Da Saúde 5

View full text Add to dashboard Cite

CIP) (eDOC BRASIL, Belo Horizonte/MG) P964 A produção do conhecimento nas ciências da saúde 5 [recurso eletrônico] / Organizador Benedito Rodrigues da Silva Neto. -Ponta Grossa (PR): Atena Editora, 2019. -(A Produção do Conhecimento nas Ciências da Saúde; v. 5) Formato: PDF 1. Abordagem interdisciplinar do conhecimento. 2. Saúde -Pesquisa -Brasil. I. Silva Neto, Benedito Rodrigues da. II. Série. CDD 610.7 Elaborado por Maurício Amormino Júnior -CRB6/2422 O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores. 2019 Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.

show abstract

Effect of pH and TPP concentration on chemico-physical properties, release kinetics and antifungal activity of Chitosan-TPP-Ungeremine microbeads

Cited by 67 publications

References 49 publications

Remineralization of dentin slices using casein phosphopeptide–amorphous calcium phosphate combined with sodium tripolyphosphate

Remineralization of dentin slices using casein phosphopeptide–amorphous calcium phosphate combined with sodium tripolyphosphate

Development of nitazoxanide-loaded colon-targeted formulation for intestinal parasitic infections: centre composite design-based optimization and characterization

Efeito Imediato Da Auriculoterapia Na Melhora Da Dor E Insônia Em Paciente Com Diagnóstico De Linfoma Não Hodgkin: Um Relato De Caso

Contact Info

Product

Resources

About