Effect of phloretin on growth performance, serum biochemical parameters and antioxidant profile in heat-stressed broilers

Hu, Hong; Bai, Xi; Xu, Kexing; Zhang, Cheng; Chen, Liang

doi:10.1016/j.psj.2021.101217

Cited by 37 publications

(17 citation statements)

References 45 publications

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“…Our results revealed that puppies in the TS group had higher HSP-70 levels after transportation, which were consistent with increased inflammatory response (TNF-a↑, IL-4↓) and oxidative stress (GSH-Px↓) caused by transportation and changing environment, while GA suppressed upregulation of HSP-70 level. Similarly, studies on other polyphenol compounds in animals also obtained similar results (70,71). Previous studies revealed that the addition of dietary GA could modulate different signaling pathways through a wide range of inflammatory cytokines and enzymatic and nonenzymatic antioxidant defense systems (72).…”

Section: Discussionmentioning

confidence: 62%

Gallic Acid Alleviates Gut Dysfunction and Boosts Immune and Antioxidant Activities in Puppies Under Environmental Stress Based on Microbiome–Metabolomics Analysis

et al. 2022

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Early-life exposure to environmental stress disrupts the gut barrier and leads to inflammatory responses and changes in gut microbiota composition. Gallic acid (GA), a natural plant polyphenol, has received significant interest for its antioxidant, anti-inflammatory, and antimicrobial properties that support the maintenance of intestinal health. To assess whether dietary supplementation of GA alleviates environmental stress, a total of 19 puppies were randomly allocated to the following three dietary treatments for 2 weeks: 1) basal diet (control (CON)); 2) basal diet + transportation (TS); and 3) basal diet with the addition of 500 mg/kg of GA + transportation (TS+GA). After a 1-week supplementation period, puppies in the TS and TS+GA groups were transported from a stressful environment to another livable location, and puppies in the CON group were then left in the stressful environment. Results indicated that GA markedly reduced the diarrhea rate in puppies throughout the trial period and caused a moderate decline of serum cortisol and HSP-70 levels after transportation. Also, GA alleviated the oxidative stress and inflammatory response caused by multiple environmental stressors. Meanwhile, puppies fed GA had a higher abundance of fecal Firmicutes and Lactobacillus and lower Proteobacteria, Escherichia–Shigella, and Clostridium_sensu_stricto_1 after transportation. As a result, the TS+GA group had the highest total short-chain fatty acids and acetic acid. Also, the fecal and serum metabolomics analyses revealed that GA markedly reversed the abnormalities of amino acid metabolism, lipid metabolism, carbohydrate metabolism, and nucleotide metabolism caused by stresses. Finally, Spearman’s correlation analysis was carried out to explore the comprehensive microbiota and metabolite relationships. Overall, dietary supplementation of GA alleviates oxidative stress and inflammatory response in stressed puppies by causing beneficial shifts on gut microbiota and metabolites that may support gut and host health.

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Section: Discussionmentioning

confidence: 62%

Gallic Acid Alleviates Gut Dysfunction and Boosts Immune and Antioxidant Activities in Puppies Under Environmental Stress Based on Microbiome–Metabolomics Analysis

et al. 2022

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“…Weaning can lead to the excessive production of oxygen-free radicals, which results in oxidative stress and is linked with reduced growth performance [ 21 , 22 ]. SOD, GSH-Px and CAT activities are the first lines against oxidative injury, and MDA was the final product of lipid peroxidation [ 23 , 24 ]. In this study, dietary fucoidan administration increased the activities of GSH-Px, SOD and CAT on day 15 and decreased the content of MDA on day 30.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Fucoidan Dietary Supplementation on Growth Performance, Serum Antioxidant Capacity, Immune Function Indices and Intestinal Morphology in Weaned Kids

Yang

Chen

Guo

et al. 2022

Animals

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The purpose of this study was to evaluate the effects of fucoidan dietary supplementation on growth performance, organs’ relative weight, serum anti-oxidation markers, immune function indices and intestinal morphology in weaned kids. A total of 60 2-month-old weaned castrated male kids (Chuanzhong black goat) were used for this 30-day experiment and randomly allocated to four groups. The control group (CON) fed a basal diet, while the other three groups were provided with the same diet further supplemented with fucoidan at 0.1%, 0.3% or 0.5%, namely, F1, F2 and F3 groups, respectively. The results indicated that dietary fucoidan supplementation significantly increased (p < 0.05) the activity of catalase (CAT) when compared to the CON group on day 15. Moreover, the addition of fucoidan at 0.3% and 0.5% significantly increased (p < 0.05) the activities of glutathione peroxidase (GSH-Px) and total superoxide dismutase (T-SOD). On day 30, dietary fucoidan supplementation significantly reduced (p < 0.05) the feed conversion rate (FCR), contents of tumor necrosis-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6), while it significantly increased (p < 0.05) the activity of total superoxide dismutase (T-SOD), the content of immunoglobulin G (IgG) and the villus height (VH) of the duodenum. Moreover, dietary 0.3% and 0.5% fucoidan supplementation significantly increased (p < 0.05) the villus height (VH) of the jejunum and ileum and significantly reduced (p < 0.05) the crypt depth (CD) of ileum. In conclusion, dietary fucoidan had positive effects on growth performance, serum anti-oxidation, immune function and intestinal morphology of weaned kids.

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“…Enzymatic and non-enzymatic antioxidant defence systems can be internally synthesized or externally supplied in response to oxidative stress and increased due to defence mechanisms against heat-induced oxidative stress ( Akbarian et al, 2016 ; Surai et al, 2019 ). The removal of free radicals in the body directly hinged on the depletion of the antioxidant factors ( Zhang et al, 2020 ), which can alter the antioxidant capacity of broiler chickens ( Hu et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of brown seaweed products on growth performance, plasma biochemistry, immune response, and antioxidant capacity of broiler chickens challenged with heat stress

Akinyemi¹,

Adewole²

2022

Poultry Science

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Effect of phloretin on growth performance, serum biochemical parameters and antioxidant profile in heat-stressed broilers

Cited by 37 publications

References 45 publications

Gallic Acid Alleviates Gut Dysfunction and Boosts Immune and Antioxidant Activities in Puppies Under Environmental Stress Based on Microbiome–Metabolomics Analysis

Gallic Acid Alleviates Gut Dysfunction and Boosts Immune and Antioxidant Activities in Puppies Under Environmental Stress Based on Microbiome–Metabolomics Analysis

The Effects of Fucoidan Dietary Supplementation on Growth Performance, Serum Antioxidant Capacity, Immune Function Indices and Intestinal Morphology in Weaned Kids

Effects of brown seaweed products on growth performance, plasma biochemistry, immune response, and antioxidant capacity of broiler chickens challenged with heat stress

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