Effect of Phoenix dactylifera seeds extract on cadmium-induced hepatotoxicity in male mice

Abstract

Heavy metals are common contaminants that have negative impacts on the body's organs and systems. Date (Phoenix dactylifera) has a great interest in biomedical applications and traditional medicine for the management of several diseases. This study evaluated the impact of Phoenix dactylifera seed extract (PDSE) on cadmium (Cd)induced hepatotoxicity in mice. Fifty mice were equally divided into five groups, G1 was negative control, G2 was injected i.p. with PDSE (300 mg/kg b.wt) daily, G3 was injected i.p. with Cd (6.5 mg/kg b.wt) daily, G4 was injected with Cd and PDSE as in G2 and 3, respectively. G5 was injected with Cd as in G3 and then with EDTA (25 mg/kg b.wt). On day 15, sera samples were collected for biochemical parameters assessment. Liver tissues were collected for the determination of oxidants/antioxidants biomarkers and histopathological investigations.The results showed that treatment with PDSE significantly ameliorated the hepatic dysfunctions in the Cdintoxicated mice evidenced by significant improvement in the ALT, AST, ALP, and total protein levels as well as in the total bilirubin and GGT levels. Furthermore, there was a significant increase in the SOD and CAT activities with a significant decrease in MDA levels after treatment of Cd-injected mice with PDSE. Also, treatment with PDSE resulted in improvement in the hepatic architectures alterations induced by Cd. PDSE showed promising metal chelating activities in vitro and in Cd-intoxicated mice by ameliorating biochemical and histopathological alterations in the liver tissues induced by Cd of mice.

Biochemical and Histochemical Assessment of the Protective Effects of Aqueous and Ethanol Fruit Extracts of Phoenix Dactylifera on Mercury-induced Liver Toxicity

“…Date palm (Phoenix dactylifera) fruits are good source of energy, vitamins such as vitamin A, vitamin B6 (pyridoxine), vitamin K, and a group of elements like phosphorus, iron, potassium, and a signi cant amount of calcium [6,7]. Dates are widely used in traditional medicine for the treatment of various disorders e.g., memory disturbances, fever, in ammation, paralysis, loss of consciousness, nervous disorders [8].…”