Effect of photodynamic therapy with photodithazine on morphofunctional parameters of M-1 sarcoma

Abstract

Efficiency and mechanisms of action of photodynamic therapy of M-1 sarcoma were studied experimentally on rats using photodithazine, a novel chlorine photosensitizer. The tissue and cellular targets for this agent are vascular wall, plasma membrane of tumor cells, and intracellular structures responsible for proliferation and biosynthesis.

Relationship between Antitumor Efficiency of Photodynamic Therapy with Photoditasine and Photoenergy Density

“…The study was carried out on random-bred male albino rats aged 3 months (160-180 g) with M-1 sarcoma implanted subcutaneously in the right thigh [1,3]. On days 12-14 after implantation the animals were intravenously injected with 2.5 mg/kg photoditasine and after 1.5 h PDT was carried out.…”

“…The nuclear organizer regions (NOR) were studied by the AgNOR method [14]. Apoptotic index of tumor cells was evaluated on hematoxylin and eosin-stained preparations impregnated by the method of Moser [1,3]. …”

“…We previously demonstrated high efficiency of photodynamic therapy of M-1 sarcoma in rats with a new chlorine photosensitizer photoditasine (N-methylglucamine chlorine e 6 salt) [1].…”

Laser-Induced Thermotherapy and Photodynamic Therapy in Dermatology: Opportunities and Future Horizons

“…Определение клеточных и тканевых мише-ней ФДТ, а также механизмы ее действия посто-янно служат объектами исследований [11][12][13][14][15][16][17][18][19]. Благодаря способности фотосенсибилизаторов накапливаться в опухоли в процессе ФДТ про-исходит избирательное повреждение ткани опухоли.…”

Photodynamic Therapy in Patients With Different Clinical Forms of Basal Cell Carcinoma of the Skin

“…ФДТ -разновидность фотохимиотерапии, ос-нованная на фотодинамическом повреждении клеточных и тканевых мишеней за счет сочетанно-го действия фотосенсибилизатора, света и кисло-рода [6][7][8][9][10][11][12][13][14]. Первоначально возможности метода ограничивались парентеральным способом вве-дения в организм фотосенсибилизатора.…”