Effect of phototherapy on neonatal riboflavin status

Tan, Keng Leong; Karim, Shahid

doi:10.1016/s0022-3476(78)81176-7

Cited by 27 publications

(17 citation statements)

References 7 publications

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“…Several studies have shown that riboflavin status, measured by glutathione reductase ac tivity index, deteriorates with phototherapy for neonatal jaundice in both term [7][8][9] and preterm infants [9], Our study is in keeping with these studies and is not unexpected given that human breast milk riboflavin content is marginal [14]. During the first 6 days of life, no age-related changes in the AC that were independent of phototherapy were present.…”

Section: Discussionsupporting

confidence: 86%

“…Several studies have shown that riboflavin status deteriorates when phototherapy is used for neonatal jaundice in term infants [7][8][9]. The maximum absorption spectrum of ribo flavin (450 nm) is within the spectrum of maximum light emission (425-475 nm) of fluorescent bulbs used to photo-degrade bili rubin to more soluble products in the jaun diced newborn.…”

Section: Introductionmentioning

confidence: 99%

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Significance of Phototherapy-Induced Riboflavin Deficiency in the Full-Term Neonate

Amin

Shukla²,

Snyder³

et al. 1992

Neonatology

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As a result of impaired fatty acid oxidation, a characteristic urinary dicarboxylic aciduria occurs in the riboflavin deficient animal. We compared the occurrence of riboflavin deficiency induced by phototherapy with changes in urinary organic acid profiles in 8 full-term, breast-fed neonates who received phototherapy for hyperbilirubinemia, and in 10 full-term, breastfed controls. Riboflavin status was assessed by measuring flavin adenine dinucleotide saturation of erythrocyte glutathione reductase. All 8 neonates exposed to phototherapy developed riboflavin deficiency (p < 0.001). Riboflavin deficiency was progressive with the duration of phototherapy. None of the controls was riboflavin deficient. Urine organic acid profiles indicative of mitochondrial acyl-CoA dehydrogenase activity (fatty acid β-oxidation, quantitated by gas chromatography mass spectrometry) showed no changes between the study and control groups in mono-, di-, or tricarboxylic acids or other organic acids. The riboflavin deficiency induced by phototherapy in full-term neonates was not of sufficient severity to limit riboflavin-dependent fatty acid oxidation.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Significance of Phototherapy-Induced Riboflavin Deficiency in the Full-Term Neonate

Amin

Shukla²,

Snyder³

et al. 1992

Neonatology

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“…Evidence has accumulated to suggest that a similar PERCENTAGE OF GRADIENT photochemical reaction occurs in jaundiced infants receiving phototherapy (4,12). studies in our laboratory have determined that Sedimentation was from is not dependent on the generation of singlet oxygen (3).…”

mentioning

confidence: 93%

Short Communication. Photochemical Reactions of Riboflavin: Covalent Binding to DNA and to Poly (dA) · Poly (dT)

Ennever

Speck

1983

Pediatr Res

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Summaryriboflavin, Sigma Chemical Co. (14); D-[2-14C]-riboflavin, Amersham (15); biochemical grade CsCl (99.9%), Gallard-~chlesin~er Standard phototherapy human in the pres-Chemical Co, (16); toluene, trichloroacetic acid and high purity ence of riboflavin is known to produce single-strand breaks in argon, Fisher Scientific Co, (17), Omnifluor, New England Nuintracellular DNA. A new photochemical reaction is described clear between riboflavin and purified DNA in which an adduct is formed.DNA was dissolved in SSC (0.015 NaC1, 0.0015 Unlike the previously described oxygen-dependent reaction be-sodium citrate) at a concentration of 1 mg/ml and allowed to tween light-activated riboflavin and deoxyguanosine, this new stand for at least 48 at 4 0~ before use in order to assure complete photochemical reaction is oxygen-independent and involves deoxyadenosine or thymidine.dispersion. Poly (dA) .poly (dT) and poly (dG)-poly (dC) were dissolved in 1/10 SSC at a concentration of 85 ua/ml and either used immediately or stored at -20°C. ['*c]-~ibudflavin in 1/10

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“…In addition to these dietary effects, sev eral studies have shown that riboflavin sta tus deteriorates with phototherapy used for neonatal jaundice (vide infra) in both term [6,8,16] and preterm infants [6]. However in our own study [9] and that of Meloni et al [10], the effects of riboflavin intake far out weighed those of phototherapy, though pho todegradation of riboflavin in vivo might be of importance in human milk-fed infants whose riboflavin intake is marginal.…”

Section: Biochemical Evidence For Riboflavin Deficiency In Preterm Inmentioning

confidence: 52%

Occurrence and Significance of Riboflavin Deficiency in Preterm Infants

Lucas

Bates²

1987

Neonatology

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Few studies have explored the importance of riboflavin deficiency in premature infants. Infants receiving human milk during the first 2 weeks become biochemically riboflavin-deficient, partly through photodegradation of riboflavin during the banking and delivery of human milk. Animal studies have shown that the metabolic lesions of riboflavin deficiency in sucking neonates differ in important ways from those seen later after weaning. Techniques are described for non-invasive study of functional riboflavin requirements by premature infants. It appears prudent to supplement human milk-fed babies with at least 300 μg riboflavin/day; but the potential danger of over supplementation in infants exposed to phototherapy is discussed.

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Effect of phototherapy on neonatal riboflavin status

Cited by 27 publications

References 7 publications

Significance of Phototherapy-Induced Riboflavin Deficiency in the Full-Term Neonate

Significance of Phototherapy-Induced Riboflavin Deficiency in the Full-Term Neonate

Short Communication. Photochemical Reactions of Riboflavin: Covalent Binding to DNA and to Poly (dA) · Poly (dT)

Occurrence and Significance of Riboflavin Deficiency in Preterm Infants

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