Effect of Phyllanthus niruri Extract on Low Density Lipoprotein of Dyslipidemic White Rats (Rattus norvegicus)

Feliciana, Anastasia; Stefanus, Andre; Ev, Felix; P, Yosua Anthony; Suryanti, Iin; Ghozali, Ahmad; S, Rita Cempaka; Indrawati, F

doi:10.36648/2472-0151.5.2.100044

Cited by 2 publications

(3 citation statements)

References 7 publications

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“…Also, hyperlipidemic rats that received Psyllium husk ethanolic extract exhibited diminished lipogram and augmented HDL-C in parallel to the hyperlipidemic group (52). Other studies exhibited that flavonoids in P. niruri have a protective effect on LDL cholesterol to not be oxidized (10,67). These findings are similar to the former studies (37,44).…”

Section: Discussionsupporting

confidence: 79%

“…Phyllanthus niruri (PN), a typical member of family Euphorbiaceae, has curative properties due to the presence of bioactive phytochemicals (alkaloids, terpenoids, lignans, polyphenols, tannins, coumarins and saponins). Saponins and alkaloids are active components in the extract of PN that can lower cholesterol and fat levels (10). Moreover, several evidence suggest that the extracts of PN possess a prevalent sort of pharmacological deeds like antimicrobial, antioxidant, anti-cancer, anti-inflammatory, hepatoprotective, lipid lowering action, anti-diabetic, and anti-fungal action (11).…”

Section: Introductionmentioning

confidence: 99%

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Alleviation Harmful Effects of Non- Alcoholic Fatty Liver Disease With Phyllanthus Niruri Extract in Albino Rats

Hashem,

Hashish,

Atteya

2021

SVR

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Non-alcoholic fatty liver disease (NAFLD) is a serious global health problem that is strongly linked to insulin resistance, obesity, and oxidative stress. The goal of current work was to inspect the hepatoprotective and hypolipidemic effects of Phyllanthus niruri ethanolic extract (PNEE) on high fat hyperlipidemic diet –induced rat's fatty liver. A unique high-fat diet (HFD) composed of coconut oil (7.3%), beef tallow (7.3%), safflower oil (0.4%) and cholesterol (1.5%) were used in the present study for induction of NAFLD or hyperlipidemia in male Albino rats. Forty-eight clinically healthy male Albino rats were equally divided into four groups: the first served as control. The second group, rats administered ethanol extract of Phyllanthus niruri (PN) (250 mg/kg b.wt.); while the third group was rats fed diet supplemented high fat concentrated (HFCD); and the fourth was rats received combination of HFCD and PN (HFCD+PN). All treatments were given daily by oral route for 105days. All treatments were given daily by oral route for 105 days. Treatment of hyperlipidemic rats by PNEE resulted in reduction of serum liver enzymes, and improvement in proteins and lipids profile, as well as pancreatic function tests, in comparison with hyperlipidemic rats (gp.3) which showed severe biochemical alterations. This was confirmed by histopathological findings in the liver. It could be concluded that PNEE treatment has a strong hepatoprotective impact against fatty alterations in animal models, suggesting that PNEE could be used as a promising agent to prevent fatty liver disease.

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Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Alleviation Harmful Effects of Non- Alcoholic Fatty Liver Disease With Phyllanthus Niruri Extract in Albino Rats

Hashem,

Hashish,

Atteya

2021

SVR

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“…Meniran (Phyllanthus niruri Linn.) contains active compounds such as flavonoid, tannin, alkaloid, saponin and terpenoid 1 . Flavonoid have some benefits, including anticancer, antioxidant, antiinflammatory, and antiviral properties 2 .…”

Section: Introductionmentioning

confidence: 99%

Characterization and Phytochemical Screening of Meniran (Phyllanthus niruri Linn) Extract's Nanoparticles Used Ball Mill Method

Sabdoningrum¹,

Hidanah²,

Chusniati³

2021

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Alkaloid test: Conducted by the method of Mayer, Wagner and Dragendorff. A sample of 3 mL was added with 5 mL of 2 M HCl, stirred and cooled at room temperature. After that, 0.5 g of NaCl was added to the already cool sample then stirred and filtered. The filtrate obtained was added with drops of 2 M HCl, then separated into 4 parts (A, B, C, D). Filtrate A was used as blank, filtrate B was added to Mayer's reagent, filtrate C was to be added to Wagner reagent, while filtrate D was used for the confirmation test. Precipitate would be formed on the addition of Mayer and Wagner reagents, when identification indicates the presence of alkaloid. Confirmation test was carried out by adding 25% ammonia to filtrate D until PH changed to 8-9. Then chloroform was added, and evaporated in water bath. Then 2M HCl was added, stirred and filtered. The filtrate was divided into 3 parts. Filtrate A was used as blank, filtrate B was tested with Mayer's reagent, while filtrate C was tested with Dragendorff's reagent. The formation of a precipitate indicated the presence of alkaloid.Tannin test: 2 grams of sample was put into a mL boiling flask, then added 350 mL of distilled water and refluxed for 3 hours. The sample was cooled and transferred into 500 ml volumetric flask, then filtered and 2 ml of the filtrate was put into a 100 ml volumetric flask. 2 ml of Folin Denis reagent and 5 ml of saturated Na 2 CO 3 were added and allowed to stand for 40 minutes then the absorbance was measured at wavelength of 725 nm.

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Effect of Phyllanthus niruri Extract on Low Density Lipoprotein of Dyslipidemic White Rats (Rattus norvegicus)

Cited by 2 publications

References 7 publications

Alleviation Harmful Effects of Non- Alcoholic Fatty Liver Disease With Phyllanthus Niruri Extract in Albino Rats

Alleviation Harmful Effects of Non- Alcoholic Fatty Liver Disease With Phyllanthus Niruri Extract in Albino Rats

Characterization and Phytochemical Screening of Meniran (Phyllanthus niruri Linn) Extract's Nanoparticles Used Ball Mill Method

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