Effect of physical activity on the change in carotid intima-media thickness: An 8-year prospective cohort study

Abstract

Background and aims There is a demand for longitudinal studies that use both objective and subjective measures of physical activity to investigate the association of physical activity with the change in carotid intima-media thickness (CIMT). In order to investigate such association, we conducted an 8-year follow-up study that used both objective and subjective measures of physical activity. Methods This cohort study used subsamples of the ongoing Korean Genome and Epidemiology Study (KoGES). Included participants were between 49 to 79 years of age at baseline. Exclusion criteria included incomplete assessments of pedometer/accelerometer, international physical activity questionnaire (IPAQ), and baseline CIMT. Participants with a history of cardiovascular diseases were further excluded. Linear regression models were used for the main analysis. Age differences were assessed by stratifying the participants into < 60 years and ≥ 60 years. Results After removing excluded participants, 835 participants were included in the final analysis (age, 59.84 ± 6.53 years; 326 (39.04%) males). 453 participants were < 60 years and 382 participants were ≥ 60 years. The daily total step count was inversely associated with the percent change in overall CIMT over 8-years (β = -0.015, standard error = 0.007, P = 0.034). This association was present among participants in the < 60-year-old group (β = -0.026, standard error = 0.010, P = 0.006), but not among participants in the ≥ 60-year-old group (β = -0.010, standard error = 0.011, P = 0.38). Conclusions The findings suggest that taking preemptive actions of increasing physical activity may prevent the incidence of atherosclerosis.

Different Associations of Coffee Consumption with the Risk of Incident Metabolic Dysfunction-Associated Steatotic Liver Disease and Advanced Liver Fibrosis

“…After excluding men whose alcohol consumption was ≥30 g/day and women whose alcohol consumption was ≥20 g/day, we classified participants into non-drinkers and current drinkers. Physical activity was measured using the International Physical Activity Questionnaire—long form [ 28 ], and the results were reported as the metabolic equivalent of task hours per day (MET-hr/day). The participants were grouped into three categories based on their physical activity levels: low (<7.5 MET-hr/day), moderate (7.5–30 MET-hr/day), and high (>30 MET-hr/day).…”

Relationship between objectively measured physical activity and subclinical cardiovascular disease: a systematic review

“…70 Five other studies showed that increased time spent in PA, of non-specific or light intensity, was related to reduced risk of carotid artery atherosclerosis. 26 27 34 71 72 Parsons et al found an association between increased SB and worse cIMT, while an inverse relationship was found between LPA and MVPA with cIMT, although MVPA did not have a stronger association than LPA. 65 Several studies (n=5) found no Open access relationship between cIMT and PA. 20 49 73-75 Other studies (n=4) found a negative association between cIMT and PA and/or a positive association between cIMT and SB, but not after adjusting for confounders.…”