Effect of physical exercise on brain and lipid metabolism in mouse models of multiple sclerosis

Houdebine, Léo; Gallelli, Cristina Anna; Rastelli, Marialetizia; Sampathkumar, Nirmal Kumar; Grenier, Julien

doi:10.1016/j.chemphyslip.2017.06.002

Cited by 22 publications

(20 citation statements)

References 83 publications

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“…Evidences suggests that exercise training is a significant factor against neurological diseases, including improved motor functions, promoted neuronal survival, moderated proinflammatory cytokine levels, increased neurotrophic factors expression, and reduced demyelination and axonal injury [6,8,34,38,60,74]. Our findings are in accordance with previous studies that showed HIIT was more effective than moderate-intensity aerobic training in cerebral plasticity and HIIT could induce higher cerebral concentrations of p75N-TR in neurological disorders [62].…”

Section: Discussionsupporting

confidence: 92%

“…It has been suggested that oligodendrogliagenesis may occur via the increased survival and proliferation of OL lineage cells and their maturation into OLs [53]. In accordance with our findings, the previous studies on the effect of physical exercise on oligodendroglial cell lineage have shown that exercise training protects of oligodendrocyte precursor cells (OPC) and mature OLs against axonal damage [8,34]. Yoon et al showed that exercise training and dietary fat regulates myelinogenesis and alter OL numbers in the adult central nervous system [75].…”

Section: Discussionsupporting

confidence: 89%

“…Souza and colleagues demonstrated that physical exercise exhibited decreased levels of free radicals, and damage to lipids and protein, especially in the CNS after EAE induction. It seems that exercise mediated neuroinflammation into the central nervous system after mouse models of multiple sclerosis [9,34]. The function of microglia depends on their phenotype, microglia in an anti-inflammatory state could promote remyelination by phagocytosis of myelin debris and secretion of cytokines and growth factors [57].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, prior swimming exercise has a protective effect on axonal damage in the spinal cord of EAE mice [8]. Furthermore, both running and swimming protocols are shown to protect against oligodendrocyte (OL) loss in the corpus callosum during the demyelination protocol [34].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Two Training Programs on Transcriptional Levels of Neurotrophins and Glial Cells Population in Hippocampus of Experimental Multiple Sclerosis

et al. 2018

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The aim of the present study was to investigate the effects of high-intensity interval training (HIIT) versus low-intensity continuous training (LICT) on transcriptional levels of neurotrophic factors and oligodendrocyte/microglia cell loss in a cuprizone (CP) induced animal model of demyelination. Male C57BL/6 mice were assigned to six groups: control (C), cuprizone-induced demyelination (CP), interval training (IT), continuous training (CT), IT plus CP (ITCP), and CT plus CP (CTCP). Training programs on the treadmill were performed for four weeks, and then demyelination was induced by feeding mice a diet containing 0.2% cuprizone for five weeks. Animals that received cuprizone showed poorer motor function, lower expression of BDNF, GDNF, NGF, and fewer oligodendrocytes in the hippocampus compared to the control animals. The numbers of oligodendrocyte and microglia cells increased in the ITCP group compared to the CTCP group (P<0.05). Both training programs increased the mRNA levels of BDNF, GDNF and NGF, and the HIIT program was more effective than the LICT program (P<0.05). Both exercise programs prevented the abnormal neurological movements induced by cuprizone. Our results indicated that HIIT versus LICT had a greater neuroprotective effect against multiple sclerosis by improving gene expression for abnormal neurotrophins and cellular loss in the hippocampus.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Two Training Programs on Transcriptional Levels of Neurotrophins and Glial Cells Population in Hippocampus of Experimental Multiple Sclerosis

et al. 2018

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“…Exercise also holds promise as an effective preventative therapy for inflammatory demyelination (for a review, see Ref. 146). Pryor et al demonstrated that exercise attenuated demyelination in mice, a finding confirmed by subsequent studies.…”

Section: Inflammation As a Link Between Peripheral Health And Myelin mentioning

confidence: 99%

White matter pathways as both a target and mediator of health behaviors

Porter

Leckie

Verstynen

2018

Annals of the New York Academy of Sciences

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Health behaviors arise from the dynamics of highly interconnected networks in the brain and variability in these networks drives individual differences in behavior. In this review, we show how many factors that predict the physical health of the body also correlate with variability of the myelinated fascicles, called white matter, that connect brain regions together. The general pattern present in the literature is that as predictors of physical health decline, there is often a coincident reduction in the integrity of major white matter pathways. We also highlight a plausible mechanism, inflammatory pathways, whereby health-related activation of the immune system can impact the myelin sheath, a protective tissue that facilitates long range communication in the brain. The growing body of evidence supports the hypothesis that degrading health in the periphery may disrupt the communication efficiency of the macroscopic neural circuits that mediate complex behaviors, which can in turn contribute to poorer physical health.

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Lung-Brain Crosstalk in Sepsis: Protective Effect of Prophylactic Physical Exercise Against Inflammation and Oxidative Stress in Rats

et al. 2022

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Effect of physical exercise on brain and lipid metabolism in mouse models of multiple sclerosis

Cited by 22 publications

References 83 publications

Effects of Two Training Programs on Transcriptional Levels of Neurotrophins and Glial Cells Population in Hippocampus of Experimental Multiple Sclerosis

Effects of Two Training Programs on Transcriptional Levels of Neurotrophins and Glial Cells Population in Hippocampus of Experimental Multiple Sclerosis

White matter pathways as both a target and mediator of health behaviors

Lung-Brain Crosstalk in Sepsis: Protective Effect of Prophylactic Physical Exercise Against Inflammation and Oxidative Stress in Rats

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