Effect of physical exercise on muscle mass and strength in cancer patients during treatment—A systematic review

Stene, Guro Birgitte; Helbostad, Jorunn L.; Balstad, Trude Rakel; Riphagen, Ingrid I.; Kaasa, Stein; Oldervoll, Line Merete

doi:10.1016/j.critrevonc.2013.07.001

Cited by 176 publications

(119 citation statements)

References 51 publications

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“…The beneficial effects on UBMS and LBMS correspond to the results reported in a previous systematic review65 but are smaller than reported in a previous aggregate meta-analysis 5. One explanation could be that we included more recent studies in our analysis.…”

Section: Discussionsupporting

confidence: 80%

Effects and moderators of exercise on muscle strength, muscle function and aerobic fitness in patients with cancer: a meta-analysis of individual patient data

Sweegers¹,

Altenburg

Brug

et al. 2018

Br J Sports Med

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Section: Discussionsupporting

confidence: 80%

Effects and moderators of exercise on muscle strength, muscle function and aerobic fitness in patients with cancer: a meta-analysis of individual patient data

Sweegers¹,

Altenburg

Brug

et al. 2018

Br J Sports Med

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“…Positive effects of exercise interventions in cachectic patients have already been discussed in the current literature, although evidence-based knowledge and studies with large cohorts are lacking [1,25]. The benefits of physical exercise on muscle strength during cancer treatment have recently been reviewed and confirmed for adult cancer patients by Stene et al [35] and should be proven for children in future studies.…”

Section: Discussionmentioning

confidence: 91%

Motor performance in children and adolescents with cancer at the end of acute treatment phase

et al. 2014

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“…A systematic review48 examined the effect of physical exercise on muscle mass and strength during anticancer treatment and compared the relative effects of aerobic and resistance training. In total, 16 studies were included but most examined patients with stage I–III breast cancer, prostate cancer or patients undergoing stem cell transplants.…”

Section: Physical Exercisementioning

confidence: 99%

Cancer cachexia: rationale for the MENAC (Multimodal—Exercise, Nutrition and Anti-inflammatory medication for Cachexia) trial

Solheim

Laird

Balstad

et al. 2018

BMJ Support Palliat Care

147

110

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Cancer cachexia is a multifactorial syndrome characterized by an on-going loss of skeletal muscle mass that cannot be fully reversed by conventional nutritional support alone. Cachexia has a high prevalence in cancer and a major impact on patient physical function, morbidity and mortality. Despite the consequences of cachexia, there is no licensed treatment for cachexia and no accepted standard of care. It has been argued that the multifactorial genesis of cachexia lends itself to therapeutic targeting through a multimodal treatment. Following a successful phase II trial, a phase III randomized controlled trial of a multimodal cachexia intervention is underway.Termed the MENAC trial (Multimodal -Exercise, Nutrition and Anti-inflammatory medication for Cachexia), this intervention is based on evidence to date and consists of Non-steroidal Antiinflammatory Drugs (NSAID) and eicosapentaenoic acid (EPA) to reduce inflammation, a physical exercise programme using resistance and aerobic training to increase anabolism, as well as dietary counselling and oral nutritional supplements to promote energy and protein balance. Herein we describe the development of this trial.

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Effect of physical exercise on muscle mass and strength in cancer patients during treatment—A systematic review

Cited by 176 publications

References 51 publications

Effects and moderators of exercise on muscle strength, muscle function and aerobic fitness in patients with cancer: a meta-analysis of individual patient data

Effects and moderators of exercise on muscle strength, muscle function and aerobic fitness in patients with cancer: a meta-analysis of individual patient data

Motor performance in children and adolescents with cancer at the end of acute treatment phase

Cancer cachexia: rationale for the MENAC (Multimodal—Exercise, Nutrition and Anti-inflammatory medication for Cachexia) trial

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