Effect of piperine in the regulation of obesity-induced dyslipidemia in high-fat diet rats

Abstract

Objective:The present study was undertaken to explore the effect of piperine in obesity-induced dyslipidemia.Materials and Methods:Male Sprague Dawley rats were fed high-fat diet (HFD) for the first eight weeks, to develop obesity-induced dyslipidemia. Later on piperine (40 mg / kg) and sibutramine (5 mg / kg) were administered for three weeks along with the continuation of HFD to two separate groups, which served as the test and standard groups, respectively. Body weight, food intake, serum triglyceride, total cholesterol, LDL, VLDL, and HDL were measured at the end of the fourth, eighth (before treatment), and eleventh (after treatment) week, while the fat mass was measured at the end of the eleventh week in the normal, HFD-control, test, and standard groups.Results:Supplementing piperine with HFD significantly reduced not only body weight, triglyceride, total cholesterol, LDL, VLDL, and fat mass, but also increased the HDL levels, with no change in food intake.Conclusion:The above results suggest that piperine possesses potential fat reducing and lipid lowering effects, without any change in food appetite, at a small dose of 40 mg / kg. The mechanism of action for such an activity needs to be determined. However, looking to structural similarity with the presently known Melanocortin-4 (MC-4) agonists, involvement of MC-4 receptors in its activity can be guessed.

Piperine’s mitigation of obesity and diabetes can be explained by its up-regulation of the metabolic rate of resting muscle

“…A number of targets have been identified, but none have been shown to be causative (31,33,(38)(39)(40). Our data show that piperine enhances thermogenesis of resting muscle via a perturbation of the SRX/DRX ratio, thus providing a mechanism.…”

Antiobesity Activity of <i>Bauhinia purpurea</i> Extract: Effect on Hormones and Lipid Profile in High Calorie Diet Induced Obese Rats

“…Lean body mass, fat free mass and total body fat and fat percentage were calculated as described previously [11] [43].…”

“…Diet intervention study in rodents is a good model to evaluate the anti obesity efficacy of a durg/formulation. Rats fed on high calorie diet (HCD) develop dyslipidemia and obesity which bear close resemblance to human obesity [11].…”

Clinical Safety of Selected Ayurvedic Formulations in Obesity and Dyslipidemia

“…21,22 Piperine significantly possesses a lipid-lowering effect and antiobesity activity without any change in appetite. 23 Piper nigrum L. extracts have shown results in reducing the 24 Ginger (Zingiber officinale Roscoe, Zingiberaceae) has been reported to ameliorate hyperlipidemia, hyperglycemia, oxidative stress, and inflammation. 25 It has potential in managing obesity, accompanying with an intervention-genotype interaction effect.…”