Effect of piperine on inhibition of FFA induced TLR4 mediated inflammation and amelioration of acetic acid induced ulcerative colitis in mice

Gupta, Rohit A.; Motiwala, Meha N.; Dumore, Nitin G.; Danao, Kishor; Ganjare, Anjali

doi:10.1016/j.jep.2015.01.039

Cited by 111 publications

(55 citation statements)

References 36 publications

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“…Decreased pro‐inflammatory cytokine production by piperine‐treated B lymphocytes is mirrored in many other cell types, including macrophages (Bae et al ., ; Ying et al , ) and synoviocytes (Bang et al , ). This is consistent with a beneficial effect of piperine on animal models of disease‐causing inflammation (Umar et al , ; Aswar et al , ; Gupta et al , ) because IL‐6 has been implicated in the pathogenesis of several autoimmune and chronic inflammatory diseases (Ishihara and Hirano, ). In contrast, a piperine‐mediated reduction in B cell synthesis of IL‐10 is not desirable because IL‐10‐producing B regulatory cells have been implicated in the suppression of disease‐causing autoimmune and inflammatory immune responses (Lund, ).…”

Section: Discussionsupporting

confidence: 78%

“…The anti‐inflammatory activities of piperine suggest that this pungent alkaloid may be useful in the treatment of various inflammatory disorders (Srinivasan, ; Meghwal and Goswami, ). For instance, oral administration of piperine protects mice from acetic acid‐induced ulcerative colitis (Gupta et al , ) and reduces the severity of collagen‐induced arthritis in rats (Umar et al , ). Piperine also has a potent anti‐allergic effect in a mouse model of allergic rhinitis (Aswar et al , ).…”

Section: Discussionmentioning

confidence: 99%

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Piperine, a Pungent Alkaloid from Black Pepper, Inhibits B Lymphocyte Activation and Effector Functions

2017

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Piperine has several well-documented anti-inflammatory properties; however, little is known regarding its effect on humoral immunity. In this study, we describe the immunosuppressive effect of piperine on B lymphocytes, which are integral to the humoral immune response. Mouse B cells were cultured in the absence or presence of non-cytotoxic concentrations (25, 50, and 100 μM) of piperine during T-dependent or T-independent stimulation. Piperine inhibited B cell proliferation by causing G0/G1 phase cell cycle arrest in association with reduced expression of cyclin D2 and D3. The inhibitory effect of piperine was not mediated through transient receptor potential vanilloid-1 ion channel (TRPV1) because piperine also inhibited the proliferation of B cells from TRPV1-deficient mice. Expression of class II major histocompatibility complex molecules and costimulatory CD40 and CD86 on B lymphocytes was reduced in the presence of piperine, as was B cell-mediated antigen presentation to syngeneic T cells. In addition, piperine inhibited B cell synthesis of interleukin (IL)-6 and IL-10 cytokines, as well as IgM, IgG2b, and IgG3 immunoglobulins. The inhibitory effect of piperine on B lymphocyte activation and effector function warrants further investigation for possible application in the treatment of pathologies related to inappropriate humoral immune responses. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Piperine, a Pungent Alkaloid from Black Pepper, Inhibits B Lymphocyte Activation and Effector Functions

2017

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“…It should be noticed that the increases of SOD level only provide optimal protective effects by a sufficiently increased H 2 O 2 ‐neutralizing capacity (increase of CAT activity), while only BP showed better effects in relieving the inhibition of CAT in colitis rats, suggesting that BP has better compromising effects against intestinal oxidative stress. Rats challenged with DSS showed increased MDA levels in the colon, suggesting the induction of lipid peroxidation, which leads to oxidative stress and intestinal tissue damage, so it is possible that both types of propolis alleviated the intestinal oxidative status by dropping intestinal MDA and boosting T‐AOC levels. The activation of the antioxidant defense mechanism by propolis provides us with another explanation for its anti‐colitis activity.…”

Section: Discussionmentioning

confidence: 99%

Propolis from Different Geographic Origins Decreases Intestinal Inflammation and Bacteroides spp. Populations in a Model of DSS‐Induced Colitis

Wang

Jin

et al. 2018

Molecular Nutrition Food Res

184

129

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“…Acute inflammation is a necessary reaction of the innate immune system to protect the host from a variety of etiologic agents such as chemical injuries, thermal and mechanical stress, pathogens, antigens, and infections. 1,2) In contradistinction to acute inflammation, continuous stimulation by etiologic agents extending up to months or years cause excess levels of inflammatory mediators in macrophages.…”

mentioning

confidence: 99%

Triterpenoids Isolated from <i>Alnus japonica</i> Inhibited LPS-Induced Inflammatory Mediators in HT-29 Cells and RAW264.7 Cells

Lee

Shim

Sung

2017

Biological & Pharmaceutical Bulletin

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Alnus japonica (Betulaceae) is a broad-leaved tree easily found in damp regions within the mountains of Korea and Japan. Four triterpenoids (1-4) from the fruits of A. japonica, including the newly isolated 3β-hydroxy-lanost-9(11),23(24)-dien-25,26-diol (3), inhibited the lipopolysaccharide (LPS)-induced expression of the chemotactic cytokine interleukin (IL)-8 and nitric oxide (NO) production in HT-29 colon epithelial cells and RAW264.7 macrophages, respectively. Among these triterpenoids, compound 4, which showed the most potent inhibitory activity, effectively down-regulated LPS-induced protein expression of inducible nitric oxide synthase (iNOS) in RAW264.7 cells and in HT-29 cells. Also, compound 4 concentration-dependently inhibited the levels of LPS-induced pro-inflammatory cytokines, IL-1β and IL-6 in macrophage cells. These triterpenoids isolated from A. japonica fruits are thought to contribute to the anti-inflammatory activities of macrophage and colon epithelial cells, which are important for regulating the colon immune system. They are expected to be potential candidates for therapeutic agents against inflammatory bowel disease.

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Effect of piperine on inhibition of FFA induced TLR4 mediated inflammation and amelioration of acetic acid induced ulcerative colitis in mice

Cited by 111 publications

References 36 publications

Piperine, a Pungent Alkaloid from Black Pepper, Inhibits B Lymphocyte Activation and Effector Functions

Piperine, a Pungent Alkaloid from Black Pepper, Inhibits B Lymphocyte Activation and Effector Functions

Propolis from Different Geographic Origins Decreases Intestinal Inflammation and Bacteroides spp. Populations in a Model of DSS‐Induced Colitis

Triterpenoids Isolated from <i>Alnus japonica</i> Inhibited LPS-Induced Inflammatory Mediators in HT-29 Cells and RAW264.7 Cells

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