The results of a long-term study on the theoretical foundation of the adaptation capabilities of Brussels sprouts of the Franklin F1 and Diablo F1 hybrids to growing in the natural and climatic conditions of Crimea are figured. Recommended terms of outdoor transplanting of seedlings, substantiated the acceptance of the cultivation Brussels sprouts in winter culture, shows the duration of the phases of laying, growth, development and maturation of Brussels sprouts. The proposed elements of growing technology permit to wide the range of vegetables consumed by the population of Crimea, prolong the delivery period of Brussels sprouts to the retail chain. Research on the agrobiological assessment of brussels sprouts hybrids, development and validation of the main agrotechnological techniques affecting the formation of brussels sprouts in the natural and climatic conditions of the Russian South was performed in stationary field experiments at the Department of Vegetable Production and Plant Protection of the Academy of Bioresources and Nature Management of the Crimean Federal University during 2007-2018. The article is aimed for vegetable growers, agricultural production entrepreneurs, gardeners, farmers, research institutions staff, graduate students and students.