Effect of Plantago major on cell proliferation in vitro

Velasco-Lezama, Rodolfo; Tapia-Aguilar, Rafaela; Román-Ramos, Rubén; Vega-Ávila, Elisa; Pérez-Gutiérrez, Ma. S.

doi:10.1016/j.jep.2005.05.050

Cited by 65 publications

(35 citation statements)

References 26 publications

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“…Administration of this plant with the dose of 2 000 mg/kg showed no adverse effect [11] . The extensive in vitro and in vivo studies showed its hypoglycaemic effect [12] , haemopoietic activity on the bone marrow and spleen cells [13], antiulcer effect on asprin-induced gastric ulcer [14] , antibacterial effect on Staphylococcus aureus and Escherichia coli and antiinflammatory properties [15,16] . Its hepatoprotective activity against carbon tetrachloride (CCl 4 ) toxicity has been observed [17,18].…”

Section: Introductionmentioning

confidence: 99%

Plantago major treatment enhanced innate antioxidant activity in experimental acetaminophen toxicity

Hussan

Basah

Yusof

et al. 2015

Asian Pacific Journal of Tropical Biomedicine

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A B S T R A C TObjective: To determine the effect of Plantago major (P. major) extract on the liver injury following acetaminophen (APAP) toxicity. Methods: The male Sprague Dawley rats (n = 38) were randomly divided into normal control (n = 6) and experiment (n = 32) groups. The latter was subdivided into four groups and induced with APAP (1 000 mg/kg) per oral, followed by P. major extract and N-acetylcysteine orally to the respective groups for six days. Results: On the seventh day, the serum bilirubin, liver enzymes and tissue malondialdehyde were increased in APAP groups whereas the total protein in serum, tissue superoxide dismutase and glutathione levels were reduced. The plant extract treatment reduced the histological deteriorations such as aggregation of hepatocellular cords, formation of binucleated cells and vacuolisation of the cells with scanty cytoplasm. It also revealed significant reduction of malondialdehyde and increased level of superoxide dismutase and glutathione. The findings in the extract treated groups were comparable to the group treated with N-acetylcysteine. Conclusions: In conclusion, P. major can enhance innate antioxidant activity and ameliorate the APAP-induced liver injury.

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Section: Introductionmentioning

confidence: 99%

Plantago major treatment enhanced innate antioxidant activity in experimental acetaminophen toxicity

Hussan

Basah

Yusof

et al. 2015

Asian Pacific Journal of Tropical Biomedicine

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“…The antibacterial properties of Plantago major depends on kind of extraction method. Found that aqueous extract of Plantago major had no effect on the proliferation of E.coli and Candida albicans [21], but in our study oil extract was used.…”

Section: Discussionmentioning

confidence: 60%

Antibacterial Activity of Some Plants of Traditional Herbal Medicine in Vitro against Escherichia Coli Originated from Liquid Pig Manure

Valdovska

Gāliņa

Krasnova

et al. 2017

Proceedings of the 7th International Conference on Bioscience, Biochemistry and Bioinformatics

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The present study was designed to evaluate antimicrobial resistance of Escherichia coli (E.coli) isolated from liquid pig manure and to determine in vitro the antibacterial activity of nine traditional Latvian medical plants against various profiles of isolated antibiotic resistant E.coli. The commensal E.coli and extended-spectrum Beta-lactamase (ESBL)-producing E.coli isolates were tested to 12 antibiotics by the disk diffusion method. The in vitro antimicrobial activities of extracts of plants were evaluated, using well diffusion technique. Results showed that overall 72% of the E.coli isolates were antibiotic resistant, being divided into 55.5% resistant to up to three different classes of antibiotics and 44.5% resistant to four or more (up to 6) different classes. In the present study, majority of tested plants (Urtica dioica, Hypericum perforatum, Hippophae rhamnoides, Viburnum L., Vaccinium macrocarpon L., Cuminum cyminum L.) have not demonstrated antimicrobial activity to E.coli isolates. However, the oil extract of leaves of Plantago major, aqueous extract of green husk of Juglans regia L. and ethanol extract of seeds of Tropaeolum majus L. demonstrated activity against test cultures.

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“…When comparing among the three types of immune cell culture, R. korthalsii showed the highest proliferation potential in splenocytes. The possible explanations could be splenocytes which were isolated from the secondary lymphoid organ contain 70 to 80% of lymphocytes with high proliferation capacity and cell cycle ranged from 6 top 15 h, while the bone marrow and thymocytes which were isolated from the primary lymphoid organ only contain 30 to 40% of immune cells with high proliferation capability and longer cell cycle lasting time (15 to 32 h) (Velasco-Lezama et al, 2006). The ability of R. korthalsii methanol extract to stimulate mice lymphocyte proliferation as indicated in this study is in agreement with the results obtained by Wong and Tan (1996) who reported that the water extract of this plant stimulated the proliferation of splenocytes in vitro.…”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory effect of Rhaphidophora korthalsii on mice splenocyte, thymocyte and bone marrow cell proliferation and cytokine expression

Swee¹,

Abdul²,

Wan³

et al. 2011

Afr. J. Biotechnol.

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Rhaphidophora korthalsii methanol extract was previously found as a potential in vitro immunomodulating agent. In this study, the in vitro immunomodulatory activity of R. korthalsii methanol extract on mice splenocyte were quantified through evaluating T/NK cell population, cytokine expression (IL-2 and IFN-) and cytotoxicity against Yac-1 cell. In vitro MTT proliferation study showed that R. korthalsii methanol extract stimulate significant proliferation of splenocyte, thymocyte and bone marrow cell at 25 g/ml after 72 h incubation as compared to rIL-2. Besides, 25 g/ml of extract also enhanced T-helper 1 cytokine (IL-2 and IFN-) secretion, natural killer cell (NK1.1 + CD3 -) population and cytotoxicity against natural killer sensitive Yac-1 leukemic cell line. It was concluded that R. korthalsii methanol extract is a potential immunomodulator agent that could activate the natural killer cell.

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Effect of Plantago major on cell proliferation in vitro

Cited by 65 publications

References 26 publications

Plantago major treatment enhanced innate antioxidant activity in experimental acetaminophen toxicity

Plantago major treatment enhanced innate antioxidant activity in experimental acetaminophen toxicity

Antibacterial Activity of Some Plants of Traditional Herbal Medicine in Vitro against Escherichia Coli Originated from Liquid Pig Manure

Immunomodulatory effect of Rhaphidophora korthalsii on mice splenocyte, thymocyte and bone marrow cell proliferation and cytokine expression

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