Plantago major treatment enhanced innate antioxidant activity in experimental acetaminophen toxicity

Abstract

A B S T R A C TObjective: To determine the effect of Plantago major (P. major) extract on the liver injury following acetaminophen (APAP) toxicity. Methods: The male Sprague Dawley rats (n = 38) were randomly divided into normal control (n = 6) and experiment (n = 32) groups. The latter was subdivided into four groups and induced with APAP (1 000 mg/kg) per oral, followed by P. major extract and N-acetylcysteine orally to the respective groups for six days. Results: On the seventh day, the serum bilirubin, liver enzymes and tissue malondialdehyde were increased in APAP groups whereas the total protein in serum, tissue superoxide dismutase and glutathione levels were reduced. The plant extract treatment reduced the histological deteriorations such as aggregation of hepatocellular cords, formation of binucleated cells and vacuolisation of the cells with scanty cytoplasm. It also revealed significant reduction of malondialdehyde and increased level of superoxide dismutase and glutathione. The findings in the extract treated groups were comparable to the group treated with N-acetylcysteine. Conclusions: In conclusion, P. major can enhance innate antioxidant activity and ameliorate the APAP-induced liver injury.

Protective effect of Alhagi sparsifolia against acetaminophen-induced liver injury in mice

“…APAP oxidation in the liver produces a number of oxidative stress ROS products, such as superoxide anion radicals, hydroxyethyl radicals, OH -, and H 2 O 2 . The accumulation of H 2 O 2 exacerbates cell injury via lipid peroxidation, and MDA is a reliable biomarker of lipid peroxidation [19]. In the present study, APAP-induced toxicity increased MDA and H 2 O 2 levels in liver tissue as compared to the normal group.…”

The Efficacy of Plantago major Seed on Liver Enzymes in Nonalcoholic Fatty Liver Disease: A Randomized Double-Blind Clinical Trial

“…P. major showed potent antioxidant activity. Natural products with antioxidant properties showed hepatoprotective activity against some liver toxicity [ 37 ]. Turel et al indicated the protective effects of P. major on liver cells in mice poisoned by carbon tetrachloride [ 22 ].…”

Evaluation of the Protective Effect of Ethanolic Extract of Plantago major Plant Against CCl4 Induced Genotoxicity and Biochemical Disturbance in Rat

“…These results are in agreement with Atta et al (2006) and Turel et al (2009) they reported that P. major has a hepatoprotective effect when administered prior to CCl4 exposure. While, Hussan et al (2015) reported that administration of P. major after rat liver injury exposed to acetaminophen reduced this damage.…”

“…Methanolic and ethanolic extracts of P. major have potential to be used as an alternative or adjunct treatment to reduce inflammation-mediated cell injury following APAP toxicity (Hussan et al, 2015). P. major is one of the most studied plants.…”

“…Furthermore, experimental studies have proven that this plant has antiulcerogenic activities (Atta et al, 2005), anti-inflammatory activities (Beara et al, 2010), antigiardiasic activity (Ponce-Macotela et al, 1994), antimalarial activity (Weenen et al, 1990), anticancer activities (Mohamed et al, 2011), immunomodulatory activity (Chiang et al, 2003), wound healing activities (Zubair et al, 2012), antioxidant activities (Stanisavljevic et al, 2008 andBeara et al, 2009), antimicrobial activities (Stanisavljevic et al, 2008), antihypoglycaemic activity (Díez-Láiz et al, 2015), decreases in the levels of serum BUN urea and serum creatinine (Hong et al, 2011), hepatoprotective activity (Hussan et al, 2015), hyperlipidemic activity (Hu et al, 2014) and haemopoietic and cytotoxic activity (Velasco-Lezama et al, 2006).…”