Protective effect of Alhagi sparsifolia against acetaminophen-induced liver injury in mice

E Se tea alleviates acetaminophen-induced liver injury by activating the Nrf2 signaling pathway

“…Excessive APAP gradually depletes GSH in hepatocytes, resulting in oxidative stress in hepatocyte mitochondria, 33,34 and finally lead to liver inflammation and necrosis. 35 SOD is one of the main antioxidant enzymes in the body during oxidative stress. 36 MDA is the main product of lipid peroxidation, and it is usually used to evaluate lipid peroxidation.…”

Traditional Uses, Chemistry, Pharmacology, Toxicology and Quality Control of Alhagi sparsifolia Shap.: A Review

“…The results of content determination showed that the polysaccharide content of the extract was as high as 69.2%, thus it is supposed that the polysaccharides have a controlling effect on APAP-induced liver injury ( Aili et al, 2017 ). The hepatoprotective mechanism of Tarangabin has been partly attributed to the reduction of oxidative stress and inhibition of the expression of cytochrome P450 2E1 (CYP2E1) ( Aili et al, 2018 ). In alcoholic liver disease (ALD), Tarangabin regulates the expression levels of tumor necrosis factor (TNF)- α and toll-like receptor 4 (TLR4) mRNA by acting on the lipopolysaccharide-TLR (LPS-TLR) signaling pathway, thereby improving the severity of ALD.…”