Effect of Plasmodium falciparum infection on blood parameters and their association with clinical severity in adults of Odisha, India

Dhangadamajhi, Gunanidhi; Panigrahi, Subhendu; Roy, Shaktirekha; Tripathy, Sagnika

doi:10.1016/j.actatropica.2018.10.007

Cited by 19 publications

(13 citation statements)

References 41 publications

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“…Overall, the findings of the present study should be interpreted cautiously because hematological indices and abnormalities in malaria may differ, among other factors, with the level of disease endemicity, disease severity, nutritional and immune status of patients, iron deficiency, co-existence of hemoglobinopathies as well as demographic factors [ 6 , 13 , 25 , 35 , 42 – 48 ]. Furthermore, this study is limited by the fact that it was hospital-based, and the hematological findings might not reflect the situation at the population level, particularly among asymptomatic carriers.…”

Section: Discussionmentioning

confidence: 96%

“…Hematological abnormalities can contribute to the pathogenesis and complications of the disease [ 3 ]. Therefore, the profile of hematological indices can help physicians to predict malaria consequences and to improve malaria case management in different epidemiological situations [ 6 , 7 ]. Malaria is a leading cause of anemia worldwide and contributes to approximately 25.0% of anemia prevalence in sub-Saharan Africa [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Hematological indices and abnormalities among patients with uncomplicated falciparum malaria in Kosti city of the White Nile state, Sudan: a comparative study

et al. 2021

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Background Hematological abnormalities are common features in falciparum malaria but vary among different populations across countries. Therefore, we compared hematological indices and abnormalities between Plasmodium falciparum-infected patients and malaria-negative subjects in Kosti city of the White Nile State, Sudan. Methods A comparative, cross-sectional study was conducted at the Clinical Laboratory Unit of Kosti Teaching Hospital from June to December 2018. A total of 392 participants (192 P. falciparum-infected patients and 200 malaria-negative subjects) were recruited in the study. Hematological indices of hemoglobin (Hb), red blood cells (RBCs), white blood cells (WBCs) and platelets were measured, and their median values were statistically compared. Results The majority of P. falciparum-infected patients (67.6%) showed a low-level parasitemia. The median values of Hb concentration, RBC count, mean corpuscular volume (MCV), mean corpuscular Hb (MCH) and mean corpuscular Hb concentration (MCHC) were significantly lower in P. falciparum-infected patients, while the median red cell distribution width (RDW) was significantly higher in the patients compared to malaria-negative subjects. Anemia, low MCV, low MCH, low MCHC and high RDW were significantly associated with falciparum malaria, but parasitemia level was not significantly associated with anemia severity. The median total WBC count was non-significantly higher in P. falciparum-infected patients, with neutropenia being significantly associated with falciparum malaria. The median platelet count was significantly lower in P. falciparum-infected patients, with thrombocytopenia being significantly associated with falciparum malaria. Conclusions Falciparum malaria among patients in Kosti city of the White Nile State, Sudan is predominantly of low-level parasitemia. It is significantly associated with anemia, low MCV, low MCH, low MCHC, high RDW, thrombocytopenia and neutropenia. However, parasitemia level is not a significant predictor of anemia severity. On the other hand, leucopenia is not useful to predict falciparum malaria. Further large-scale studies in community and healthcare settings and inclusion of patients with complicated or severe malaria and those with high parasite densities are recommended.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Hematological indices and abnormalities among patients with uncomplicated falciparum malaria in Kosti city of the White Nile state, Sudan: a comparative study

et al. 2021

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“…Anemia, as well as alterations in other hematological factors, is shown to be generally affected by malaria [19][20][21]. is is particularly dangerous because recurrent malaria incidents can cause life threatening anemia and metabolic acidosis, especially in children [22,23].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Hematological Parameters in Malaria, among Adult Patients Attending the Bamenda Regional Hospital

Nlinwe

Nange

2020

Anemia

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Malaria, which is responsible for a substantial amount of deaths in endemic countries, has been shown to have both direct and indirect effects on the hematological parameters. Notwithstanding, some hematological parameters among populations living in malaria endemic regions have not been described consistently, as a standard for measuring malaria burden. Based on the above fact, this study was designed to assess some hematological changes and their diagnostic values in malaria infected patients. A total of 160 malaria positive adult patients, together with 81 healthy control adults were recruited for the study. For the malaria positive group, the female to male ratio was 1.38 : 1. Specifically, 74.38%, 10.00%, and 15.62% of those in the malaria positive group had mild, moderate, and severe parasitaemia, respectively. Leukemia, anemia, and thrombocytopenia were found to be significantly associated with malaria and were all estimated to be specific for the diagnosis of malaria. Anemia was, however, estimated to be both sensitive and specific for malaria diagnosis. Therefore, anemia offers the most diagnostic value in the malaria infected patients of this study.

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“…However, the effect of S1P and S1PR 1 signaling in human malaria has not been investigated in terms of NO production and subsequent clinical outcome. Previous studies investigating the effects of Plasmodium falciparum infections on blood indices show reduction of platelet count (thrombocytopenia) and RBCs (anemia), the two major sources for plasma S1P to be frequent and are responsible for clinical severity with fatal outcome (Birhanu et al, 2017;Punsawad and Viriyavejakul, 2017;Dhangadamajhi et al, 2019). Further, platelet count has been delineated to resolve rapidly with recovery in the absence of any additional and specific treatment (Khan et al, 2012).…”

Section: Human Erythrocytesmentioning

confidence: 99%

Sphingosine 1-Phosphate in Malaria Pathogenesis and Its Implication in Therapeutic Opportunities

Dhangadamajhi

Singh

2020

Front. Cell. Infect. Microbiol.

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Sphingosine 1-Phosphate (S1P) is a bioactive lipid intermediate in the sphingolipid metabolism, which exist in two pools, intracellular and extracellular, and each pool has a different function. The circulating extracellular pool, specifically the plasma S1P is shown to be important in regulating various physiological processes related to malaria pathogenesis in recent years. Although blood cells (red blood cells and platelets), vascular endothelial cells and hepatocytes are considered as the important sources of plasma S1P, their extent of contribution is still debated. The red blood cells (RBCs) and platelets serve as a major repository of intracellular S1P due to lack, or low activity of S1P degrading enzymes, however, contribution of platelets toward maintaining plasma S1P is shown negligible under normal condition. Substantial evidences suggest platelets loss during falciparum infection as a contributing factor for severe malaria. However, platelets function as a source for plasma S1P in malaria needs to be examined experimentally. RBC being the preferential site for parasite seclusion, and having the ability of trans-cellular S1P transportation to EC upon tight cell-cell contact, might play critical role in differential S1P distribution and parasite growth. In the present review, we have summarized the significance of both the S1P pools in the context of malaria, and how the RBC content of S1P can be channelized in better ways for its possible implication in therapeutic opportunities to control malaria.

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Effect of Plasmodium falciparum infection on blood parameters and their association with clinical severity in adults of Odisha, India

Cited by 19 publications

References 41 publications

Hematological indices and abnormalities among patients with uncomplicated falciparum malaria in Kosti city of the White Nile state, Sudan: a comparative study

Hematological indices and abnormalities among patients with uncomplicated falciparum malaria in Kosti city of the White Nile state, Sudan: a comparative study

Assessment of Hematological Parameters in Malaria, among Adult Patients Attending the Bamenda Regional Hospital

Sphingosine 1-Phosphate in Malaria Pathogenesis and Its Implication in Therapeutic Opportunities

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