Effect of platelet–lymphocyte ratio and lactate levels obtained on mortality with sepsis and septic shock

Bıyıklı, Ebru; Kayıpmaz, Afşin Emre; Kavalcı, Cemil

doi:10.1016/j.ajem.2017.12.010

Cited by 13 publications

(11 citation statements)

References 28 publications

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“…Studies were conducted in China ( n = 4) [ 12 , 22 – 24 ], Indonesia ( n = 3) [ 16 , 19 , 20 ], Turkey ( n = 3) [ 10 , 11 , 18 ], Iran ( n = 1) [ 14 ], Serbia ( n = 1) [ 13 ], Saudi Arabia ( n = 1) [ 9 ], Poland ( n = 1) [ 17 ], Korea ( n = 1) [ 15 ], and India ( n = 1) [ 21 ]. Seven studies reported one-month mortality [ 9 , 10 , 12 , 15 , 19 , 21 , 24 ], three studies reported in-hospital mortality [ 13 , 14 , 22 ], and one study investigated ICU mortality [ 17 ]. Five studies did not report any data in this regard [ 11 , 16 , 18 , 20 , 23 ].…”

Section: Resultsmentioning

confidence: 99%

“…In the subgroup analysis, according to mortality time reported in articles, there were seven studies on one-month mortality [ 9 , 10 , 12 , 15 , 19 , 21 , 24 ], including 850 septic patients, of which 469 survived, and three studies on in-hospital mortality [ 13 , 14 , 22 ], including 1553 septic patients of which 780 survived. As seen in Figure 3 , patients deceased during one month after sepsis had elevated levels of PLR compared to survivors (SMD = 1.08, 95% CI = 0.15-1.92, p = 0.22).…”

Section: Resultsmentioning

confidence: 99%

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Prognostic Value of Platelet to Lymphocyte Ratio in Sepsis: A Systematic Review and Meta-analysis

Wang

Mivefroshan

Yaghoobpoor

et al. 2022

BioMed Research International

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The goal of this study was to conduct a systematic review of the literature on the relationship between peripheral blood platelet to lymphocyte ratio (PLR) and mortality in sepsis and to integrate the findings in a meta-analysis. An electronic search of three main databases was performed: PubMed, Embase, and Scopus on 19 December 2021. Finally, 16 studies comprising 2403 septic patients, including 1249 survivors and 1154 nonsurvivors, were included in this meta-analysis. We found that PLR levels were significantly higher in nonsurvivors than in survivors (random effect model: SMD = 0.72 , 95% CI; 0.35–1.10, p < 0.001 ). However, significant heterogeneity was observed across the studies ( I 2 = 94.1 % , p < 0.01 ). So, we used random effect model in our meta-analysis. In the subgroup analysis, according to mortality time, patients deceased during one month after sepsis had elevated levels of PLR compared to survivors ( SMD = 1.03 , 95% CI = 0.15 -1.92, p = 0.22 ). However, in-hospital mortality was not associated with PLR level ( SMD = 0.41 , 95% CI = − 0.18 -0.99, p = 0.175 ). Our findings support PLR to be a promising biomarker that can be readily integrated into clinical settings to aid in the prediction and prevention of sepsis mortality.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Prognostic Value of Platelet to Lymphocyte Ratio in Sepsis: A Systematic Review and Meta-analysis

Wang

Mivefroshan

Yaghoobpoor

et al. 2022

BioMed Research International

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“…Similarly, Biyikli et al found day 1 PLR was not different between survivors and nonsurvivors in elderly patients with sepsis. 23 …”

Section: Discussionmentioning

confidence: 99%

Epidemiology and Prognostic Utility of Cellular Components of Hematological System in Sepsis

Saxena¹,

Rewari²,

Arora³

et al. 2021

Indian Journal of Critical Care Medicine

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A bstract Background Data are lacking on the role of cellular components of hematological system as biomarkers for prognosis of sepsis. We planned to identify if these parameters measured at admission to ICU and at 72 hours can be useful as prognostic marker in septic critically ill patients. Materials and methods In this prospective observational study, 130 adult patients with sepsis were recruited. Various hematological study parameters (total, differential, and absolute leukocyte count, platelet count, platelet distribution width, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio) were noted at day 1 and day 3 of admission. Primary outcome was 28-day mortality, and secondary outcomes were duration of mechanical ventilation, vasopressor requirement, ICU length of stay, and requirement of renal replacement therapy. The variables were compared between two groups and using binary regression model and were evaluated as prognostic markers for 28-day mortality. Results Data from n = 129 were analyzed. At day-28, n = 58 (44.96%) patients survived. Baseline and demographic parameters were comparable between survivors and nonsurvivors. Admission Sequential Organ Failure Assessment score was more in nonsurvivors than survivors [8 (6–8) vs 6 (4–8); p = 0.002]. In nonsurvivors, monocyte, lymphocyte, basophil, eosinophil, and platelet count were significantly less at day 1 and lymphocyte, eosinophil, basophil and platelet count were significantly less at day 3. NLR and PLR at day 3 were significantly more in nonsurvivors. On logistic regression analysis, age, thrombocytopenia on day 1, and low eosinophil count on day 3 predicted 28-day mortality ( p = 0.006, p = 0.02, and p = 0.04, respectively). Conclusion Thrombocytopenia on day 1 and eosinopenia on day 3 may predict 28-day mortality in sepsis. How to cite this article Sinha H, Maitra S, Anand RK, Aggarwal R, Rewari V, Subramaniam R, et al . Epidemiology and Prognostic Utility of Cellular Components of Hematological System in Sepsis. Indian J Crit Care Med 2021;25(6):660–667.

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“…Thrombocytopenia is also well recognized in sepsis as a result of several mechanisms, including peripheral non-immune destruction, production of cytokines and bone marrow suppression ( 10 - 12 ). Based on these alterations, there is a trend towards investigating the role of platelets to lymphocyte percentage ratio (PL%R) as a possible prognostic index in the field of sepsis ( 13 , 14 ).…”

Section: Introductionmentioning

confidence: 99%

Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Percentage Ratio as Predictors of In-hospital Mortality in Sepsis. An Observational Cohort Study

Karamouzos¹,

Paraskevas²,

Mulita³

et al. 2022

Mater Sociomed

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Background: Sepsis remains a major public health problem with increased incidence of mortality. As early recognition and prompt treatment in the first ‘golden hour’ remain the cornerstone of the septic patient approach, there is a real need for rapid and cost-effective reliable markers. Objective: The aim of the study was to evaluate the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte percentage ratio (PL%R) in patients with sepsis who were initially treated in the Emergency Department and investigate their predictive ability regarding in-hospital mortality and performance comparing them to SOFA, APACHE II, and SAPS II score. Methods: A retrospective observational study in the Emergency Department and Internal Medicine Department in a Mediterranean University Hospital. A total of forty-three patients suffering from sepsis were enrolled in the study. Demographic information, past medical history with pre-existing co-morbidities, physical examination findings, and radiological data were reviewed. Neutrophil to lymphocyte ratio and platelets to lymphocyte percentage ratio was calculated from the complete blood count (CBC). Disease severity was evaluated by calculating SOFA, SAPS II and APACHE II score on admission. The outcome of patients was noted as a primary endpoint. Results: Values of NLR and PL%R were statistically significantly higher in the group of non-survivors and correlate with sepsis prognostic scores. Conclusion: Calculation of NLR and PL%R is easy, fast, and inexpensive in the assessment of patients with sepsis. Their role as prognostic indexes and their validity in the Emergency Department setting should be evaluated with large prospective studies.

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Effect of platelet–lymphocyte ratio and lactate levels obtained on mortality with sepsis and septic shock

Cited by 13 publications

References 28 publications

Prognostic Value of Platelet to Lymphocyte Ratio in Sepsis: A Systematic Review and Meta-analysis

Prognostic Value of Platelet to Lymphocyte Ratio in Sepsis: A Systematic Review and Meta-analysis

Epidemiology and Prognostic Utility of Cellular Components of Hematological System in Sepsis

Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Percentage Ratio as Predictors of In-hospital Mortality in Sepsis. An Observational Cohort Study

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