Effect of platelet‐rich plasma on the healing of intra‐bony defects treated with a natural bone mineral and a collagen membrane

Dőri, Ferenc; Húszár, Tamás; Nikolidakis, Dimitris; Arweiler, Nicole Birgit; Gera, István; Sculean, Anton

doi:10.1111/j.1600-051x.2006.01044.x

Cited by 103 publications

(109 citation statements)

References 40 publications

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“…[27] Whereas, in both the studies of Döri et al . [2829] no significant difference in pocket reduction and CAL gain between the two groups were reported. The difference could be attributed to the reason that no blood parameters were evaluated, which may entail the risk of production of PRP volumes with low PCs leading to disappointing results.…”

Section: Discussionmentioning

confidence: 94%

Clinical and radiographic evaluation of intra-bony defects in localized aggressive periodontitis patients with platelet rich plasma/hydroxyapatite graft: A comparative controlled clinical trial

Gupta

2014

Contemp Clin Dent

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Background:Aggressive periodontitis is a characterized by rapid attachment loss, bone destruction and familial aggregation. Platelet-rich plasma (PRP) has been proposed to promote regeneration of the lost periodontal tissues. The aim of this study was to evaluate and compare the efficacy of PRP combined with hydroxyapatite (HA) graft in the treatment of intra-bony defects in localized aggressive periodontitis (L-AgP) patients.Materials and Methods:Ten L-AgP patients having bilateral intra-bony defect ≥2 mm and probing depth (PD) ≥6 mm were randomly treated either with the PRP/HA graft or HA graft alone. The clinical (plaque control record, bleeding on probing index, PD, and relative attachment level [RAL]), and radiographic parameters (size of the bone defect) were recorded pre- and post-operatively at 3, 6, and 12 months.Results:After 12 months, for both maxillary and mandibular arches, the mean PD decrease was significantly more (P < 0.05) for the test group than the control group (3.2 mm vs. 1.9 mm and 3.6 mm vs. 1.9 mm, respectively). Furthermore, the mean RAL decrease in both maxillary and mandibular arches was significantly more (P < 0.05) for the test group than the control group (3.0 mm vs. 1.2 mm and 3.1 mm vs. 1.4 mm, respectively). Radiographically, the test group showed significantly more defect fill as compared with the control group.Conclusion:Both treatments provided significant improvements in clinical and radiographic parameters in a 12-month postoperative period. PRP/HA group presented superior results regarding PD reduction, clinical attachment gain and radiographic bone fill than HA group.

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Section: Discussionmentioning

confidence: 94%

Clinical and radiographic evaluation of intra-bony defects in localized aggressive periodontitis patients with platelet rich plasma/hydroxyapatite graft: A comparative controlled clinical trial

Gupta

2014

Contemp Clin Dent

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“…[10121314] The positive impact of PRP on bone healing is attributed to angiogenic, proliferate and differentiating effect of PDGF and TGF present in high concentration. However, there is pausity of information about the clinical efficacy of PRP in repair and regeneration of periodontal defect.…”

Section: Discussionmentioning

confidence: 99%

Use of platelet rich plasma in the management of periodontal intra-osseous defects: A clinical study

Jalaluddin

Singh

Jayanti

et al. 2017

J Int Soc Prevent Communit Dent

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Background:Periodontal disease is characterized by the presence of gingival inflammation, periodontal pocket formation, loss of connective tissue attachment, and alveolar bone around the affected tooth. Alveolar bone support and attachment apparatus regeneration has been achieved through various processes and have given elusive results. An expedient and cost-effective approach to obtain autologous platelet-derived growth factor (PDGF) and transforming growth factor (TGF)-β is the use of platelet-rich plasma (PRP). PRP is obtained by sequestrating and concentrating platelets by gradient density centrifugation.Aims:The current study was aimed at evaluating the regenerative potential of platelet-rich plasma in comparison with open flap debridement.Settings and Designs:This study was a randomized controlled clinical trial conducted in the Department of Periodontics and Oral Implantology, KIDS, Bhubaneswar, Odisha.Materials and Methods:Twenty periodontal infrabony defects in 10 patients; 6 males and 4 females of age between 25–45 years were included in this study and were followed up for a period of 6 months.Statistical Analysis:Both the groups showed a mean plaque index of 2.10 and 2.50 at baseline, 1.75 and 2.05 at 3 months, and 1.28 and 1.53 at the end of 6 months. The mean reduction of 0.35 and 0.45 at three months and 0.82 and 0.97 at six months was achieved, which was statistically significant. (P < 0.001). When comparison was done between the two groups it was not found to be statistically significant (P < 0.05). In each of the group there was definitive reduction in plaque score over a period of time.Results and Conclusion:There was no statistically significant difference in the treatment outcome between open flap debridement and PRP alone. Platelet-rich plasma application holds promise and needs further exploration.

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“…But when the local conditions are not optimum, PRP gels alone are not strong enough to promote a clinical filling equivalent to the dense bone filling reached with a bone substitute [50]. Most of the randomized controlled clinical trials(RCTs) demonstrated that the addition of PRP to certain regenerative materials, doi: 10.7243/2050-1218-2-11 namely bioactive glass [51], b-TCP [52], BM and e-PTFE membranes [53], b-TCP and e-PTFE membranes [54], BM and collagen membranes [23] and BM and EMD [55], failed to confer statistically significant additive benefits in the therapy of periodontal intraosseous defects. However, according to other RCTs such adjunctive positive outcomes may result from other combinations of PRP, namely together with BM [28], DFDBA [56] and hydroxyapatite [22].…”

Section: Discussionmentioning

confidence: 99%

A clinical and radiographic evaluation of the management of periodontal osseous defects with alloplast and platelet rich plasma

Shetty¹,

Bose²

2013

J Regen Med Tissue Eng

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Effect of platelet‐rich plasma on the healing of intra‐bony defects treated with a natural bone mineral and a collagen membrane

Abstract: Within its limits, the present study has shown that (i) at 1 year after regenerative surgery with both NBM+PRP+GTR and NBM+GTR, significant PD reductions and CAL gains were found, and (ii) the use of PRP has failed to improve the results obtained with NBM+GTR.

Cited by 103 publications

References 40 publications

Clinical and radiographic evaluation of intra-bony defects in localized aggressive periodontitis patients with platelet rich plasma/hydroxyapatite graft: A comparative controlled clinical trial

Clinical and radiographic evaluation of intra-bony defects in localized aggressive periodontitis patients with platelet rich plasma/hydroxyapatite graft: A comparative controlled clinical trial

Use of platelet rich plasma in the management of periodontal intra-osseous defects: A clinical study

A clinical and radiographic evaluation of the management of periodontal osseous defects with alloplast and platelet rich plasma

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