Effect of platelet-rich plasma with autogenous bone graft for maxillary sinus augmentation in a rabbit model

Butterfield, Kevin J.; Bennett, Jeffrey; Gronowicz, Gloria; Adams, Douglas

doi:10.1016/j.joms.2004.07.017

Cited by 93 publications

(66 citation statements)

References 25 publications

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“…Some of these studies also use rabbits 5,25,26 . Aghaloo et al 5 show a very similar study to this presented here, with differences in the preparation of the PRP, in the monitoring periods (two, four and six weeks here and one, two and four months in theirs) and in the results when in the current study the PRP seemed to be harmful to the repair, these authors practically demonstrate neutral action of the PRP.…”

Section: Discussionmentioning

confidence: 99%

Effects of a highly concentrated platelet-rich plasma on the bone repair using non-critical defects in the calvaria of rabbits

et al. 2010

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PURPOSE: To verify the effect of highly concentrated platelet-rich plasma (hPRP) in the pathways of bone repair using non-critical defects in the calvaria of rabbits. METHODS: The hPRP was produced from collected venous blood of 21 rabbits. Four non-critical defects of 8 mm in diameter were created on the calvaria of each animal. The defects were all treated differently: autogenous particled bone (APB, group 1), autogenous particled bone associated with hPRP (APB + hPRP, group 2), isolated hPRP (group 3), and blood clot (control, group 4). Animals were submitted to euthanasia on the 2nd, 4th and 6th week postoperatively. Histological and histomorphometric analysis were carried through. RESULTS: After two weeks, groups 1 and 2 were in more advanced stage of repair than 3 and 4. At this period, comparing the groups 1 and 2, no significant differences were found between both, which also happened between the groups 3 and 4. However, after four and six weeks, the group 1 showed a more advanced stage of repair among all the other studied groups, while group 2 was in more advanced signs of bone repair than groups 3 and 4. Comparing groups 3 and 4, after four and six weeks, the least advanced stage of bone repair was found to be within group 3. CONCLUSION: The use of a highly concentrated PRP was considered prejudicial to the repair of non-critical defects in the calvaria of rabbits, either in the association of autogenous particled bone, when compared to autogenous particled bone alone, or in its isolated form, when compared to blood clot (control).

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Section: Discussionmentioning

confidence: 99%

Effects of a highly concentrated platelet-rich plasma on the bone repair using non-critical defects in the calvaria of rabbits

et al. 2010

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“…Even though clinical 4,20,21 and animal studies 8,22,23 reported the volume of PRP, they did not describe the volume of autogenous bone graft used. Therefore, the ratio of autogenous bone graft/PRP cannot be calculated.…”

Section: Discussionmentioning

confidence: 99%

Influence of the ratio of particulate autogenous bone graft/platelet-rich plasma on bone healing in critical-size defects: A histologic and histometric study in rat calvaria

et al. 2009

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The purpose of this study was to analyze histomorphometrically the influence of the ratio of particulate autogenous bone (AB) graft/platelet-rich plasma (PRP) on bone healing in surgically created critical-size defects (CSD) in rat calvaria. Fifty rats were divided into five groups: Group C (control), Group AB, Group AB/PRP-50, Group AB/PRP-100, and Group AB/PRP-150. A 5-mm diameter critical-size defect was created in the calvarium of each animal. In Group C, the defect was filled by blood clot only. In Group AB, the defect was filled with 0.01 mL of AB graft. In Groups AB/PRP-50, AB/PRP-100, and AB/PRP-150, the defects were filled with 0.01 mL of AB graft combined with 50, 100, and 150 mL of PRP, respectively. All animals were euthanized at 30 days postoperative. Histomorphometry, using image analysis software, and histology analyses were performed. New Bone Area (NBA) and the remaining bone graft particles area (RPA) were calculated as a percentage of the total area of the original defect. Percentage data were transformed into arccosine for analysis. No defect completely regenerated with bone. Group AB/PRP-50 (41.78 AE 13.48%) had a significantly greater NBA than Groups C (19.29 AE 5.11%), AB (27.43 AE 10.90%) or AB/PRP-150 (19.17 AE 8.45%) (p < 0.05). No significant differences were observed between groups AB/PRP-50 and AB/ PRP-100 or among groups AB, AB/PRP-100, and AB/PRP-150 with regard to NBA (p > 0.05). Group AB/PRP-150 (31.59 AE 3.22%) had a significantly greater RPA than Groups AB (19.09 AE 5.21%), AB/PRP-50 (17.33 AE 4.43%), and AB/PRP-100 (19.72 AE 3.62%) (p < 0.001). No significant differences were observed among groups AB, AB/PRP-50, and AB/PRP-100 with regard to RPA (p > 0.05). The ratio AB graft/PRP influences bone healing in surgically created CSD in rat calvaria. ß

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“…The amount of bone that can be created by these methods, however, is not sufficient for creating the 10-15 mm of bone necessary for implant stabilization [7]. Van Den Bergh et al (2000) in his study concluded that osteogenic protein-1 has the potential for initiating bone formation in maxillary sinus, so can be used instead of the gold standard autogenous bone [8]. Wheele et al (1997) in his study concluded that alloplastic material in sinus augmentation reduces the morbidity and expenses of the procedure.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Platelet Rich Plasma in Sinus Lift Augmentation

Riaz

Ravindran

Ramkumar

et al. 2010

J. Maxillofac. Oral Surg.

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The present study aims to evaluate and analyze the efficacy of Platelet Rich Plasma (PRP) with hydroxyapatite crystals for maxillary sinus augmentation procedures. A comparative study of 10 patients with a mean average age of 35 years with less than 5 mm of residual alveolar bone was conducted. Six patients underwent Lateral sinus lift procedure with allografts (platelet rich plasma and hydroxyappatite crystals) and four patients underwent the same procedure but with autografts (symphyseal). Follow-up for a period of 3 years was done. The patients were assessed for postoperative pain, sinusitis, oroantral communication, epistaxis, graft rejection, infection and potential loss of bone and teeth. During the 3 years period of follow-up there were no complications recorded. A mean post-operative augmented height of 15 mm was achieved in all the patients. Maxillary sinus lift procedure using a mixture of hydroxyapatite crystals and platelet rich plasma was found to be very effective in increasing the height of residual alveolar bone when compared to the use of autografts alone.

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Effect of platelet-rich plasma with autogenous bone graft for maxillary sinus augmentation in a rabbit model

Cited by 93 publications

References 25 publications

Effects of a highly concentrated platelet-rich plasma on the bone repair using non-critical defects in the calvaria of rabbits

Effects of a highly concentrated platelet-rich plasma on the bone repair using non-critical defects in the calvaria of rabbits

Influence of the ratio of particulate autogenous bone graft/platelet-rich plasma on bone healing in critical-size defects: A histologic and histometric study in rat calvaria

Efficacy of Platelet Rich Plasma in Sinus Lift Augmentation

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