Effect of polaprezinc on oral mucositis, irradiation period, and time to discharge in patients with head and neck cancer

Suzuki, Akio; Kobayashi, Ryo; Shakui, Toshinobu; Kubota, Yukimasa; Fukita, Masaharu; Kuze, Bunya; Aoki, Mitsuhiro; Sugiyama, Tadashi; Mizuta, Keisuke; Itoh, Yoshinori

doi:10.1002/hed.24446

Cited by 14 publications

(17 citation statements)

References 13 publications

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“…Notably, pharmacotherapies for amelioration of such adverse events were effective in reducing the duration of hospital stay . We also showed that oral intake of polaprezinc, an antigastric ulcer agent, prevented the occurrence of severe oral mucositis associated with radiotherapy and reduced the time to completion of irradiation therapy, as well as the time to discharge after completion of radiotherapy …”

Section: Introductionmentioning

confidence: 70%

“…8 We also showed that oral intake of polaprezinc, an antigastric ulcer agent, prevented the occurrence of severe oral mucositis associated with radiotherapy and reduced the time to completion of irradiation therapy, as well as the time to discharge after completion of radiotherapy. 9 Neuromuscular diseases include central and peripheral nervous system disorders, and a number of drugs, including anti-epileptics, corticosteroids, immunoglobulins, anticoagulant agents and antipsychotics, are used for therapy. In addition, patients with these diseases often suffer a number of comorbid disorders, as a result many of these patients tend to receive multidrug therapy.…”

Section: Introductionmentioning

confidence: 99%

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Relationship between number of drugs and duration of hospital stay in older patients with neuromuscular diseases

Nishida

Hayashi

Suzuki

et al. 2018

Geriatrics Gerontology Int

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Section: Introductionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Relationship between number of drugs and duration of hospital stay in older patients with neuromuscular diseases

Nishida

Hayashi

Suzuki

et al. 2018

Geriatrics Gerontology Int

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“…In the search for recently published articles about zinc, a RCT reported that zinc sulfate reduced the incidence and severity of OM in leukemia patients undergoing CT [81]. Additionally, zinc was reported to be effective in 2 comparative studies; one conducted in HSCT and the second conducted in RT for H&N cancer [12,82].…”

Section: Discussionmentioning

confidence: 99%

“…The efficacy of systemic zinc in preventing OM in H&N cancer patients was also evaluated in 2 case-control studies demonstrating conflicting results [11,12].…”

Section: Zinc (Systemic): Handn Cancer Rt/rt-ct-prevention Guideline: mentioning

confidence: 99%

Systematic review of natural and miscellaneous agents for the management of oral mucositis in cancer patients and clinical practice guidelines—part 1: vitamins, minerals, and nutritional supplements

Yarom

Hovan²,

Bossi

et al. 2019

Support Care Cancer

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Purpose To update the clinical practice guidelines for the use of natural and miscellaneous agents for the prevention and/or treatment of oral mucositis (OM). Methods A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer / International Society of Oral Oncology (MASCC/ISOO). The body of evidence for each intervention, in each cancer treatment setting, was assigned an evidence level. The findings were added to the database used to develop the 2014 MASCC/ ISOO clinical practice guidelines. Based on the evidence level, the following guidelines were determined: Recommendation, Suggestion, and No Guideline Possible. Results A total of 78 papers were identified within the scope of this section, out of which 29 were included in this part, and were analyzed with 27 previously reviewed studies. A new Suggestion was made for oral glutamine for the prevention of OM in head and neck (H&N) cancer patients receiving radiotherapy with concomitant chemotherapy. The previous Recommendation against the use of parenteral glutamine for the prevention of OM in hematopoietic stem cell transplantation (HSCT) patients was reestablished. A previous Suggestion for zinc to prevent OM in H&N cancer patients treated with radiotherapy or chemoradiotherapy was reversed to No Guideline Possible. No guideline was possible for other interventions. Conclusions Of the vitamins, minerals, and nutritional supplements studied for the management of OM, the evidence supports a Recommendation against parenteral glutamine in HSCT patients and a Suggestion in favor of oral glutamine in H&N cancer patients for the management of OM.

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“…It is associated with severe pain, odynophagia, dysgeusia, malnutrition, and dehydration, which severely impairs patients' quality of life [29,30]. It can be the cause of an extended hospital stay [45] and may even be the cause of early cessation of therapy [46]. Therefore, strategies to prevent mucositis can potentially improve outcomes and decrease hospital stays.…”

Section: Oral Mucositismentioning

confidence: 99%

A Review of Zinc-L-Carnosine and Its Positive Effects on Oral Mucositis, Taste Disorders, and Gastrointestinal Disorders

Hewlings

2020

Nutrients

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Zinc-L-carnosine (ZnC), also called polaprezinc known as PepZin GI™, is a chelated compound that contains L-carnosine and zinc. It is a relatively new molecule and has been associated with multiple health benefits. There are several studies that support ZnC’s benefits in restoring the gastric lining, healing other parts of the gastrointestinal (GI) tract, improving taste disorders, improving GI disorders, and enhancing skin and liver. Oral mucositis is a common complication of cytotoxic radiotherapy and/or chemotherapy. It occurs in almost every person with head and neck cancer who receive radiotherapy. It is often overlooked because it is not considered life threatening. However, mucositis often leads to a decreased quality of life and cessation of treatment, ultimately decreasing positive outcomes. Therefore, solutions to address it should be considered. The primary mechanisms of action are thought to be localized and related to ZnC’s anti-inflammatory and antioxidant functions. Therefore, the purpose of this review is to discuss the research related to ZnC and to explore its benefits, especially in the management of conditions related to damaged epithelial cells, such as oral mucositis. Evidence supports the safety and efficacy of ZnC for the maintenance, prevention, and treatment of the mucosal lining and other epithelial tissues. The research supports its use for gastric ulcers (approved in Japan) and conditions of the upper GI and suggests other applications, particularly for oral mucositis.

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Effect of polaprezinc on oral mucositis, irradiation period, and time to discharge in patients with head and neck cancer

Abstract: P-AG reduced the irradiation period and the time to discharge after completion of radiotherapy by preventing oral mucositis in patients with head and neck cancer. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1387-1392, 2016.

Cited by 14 publications

References 13 publications

Relationship between number of drugs and duration of hospital stay in older patients with neuromuscular diseases

Relationship between number of drugs and duration of hospital stay in older patients with neuromuscular diseases

Systematic review of natural and miscellaneous agents for the management of oral mucositis in cancer patients and clinical practice guidelines—part 1: vitamins, minerals, and nutritional supplements

A Review of Zinc-L-Carnosine and Its Positive Effects on Oral Mucositis, Taste Disorders, and Gastrointestinal Disorders

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