Effect of Policosanol on Isoprenaline-induced Myocardial Necrosis in Rats

Abstract

Policosanol is a mixture of higher aliphatic primary alcohols isolated from sugar cane (Saccharum officinarum L.) and octacosanol represents its main component. This study was conducted to examine the effects of policosanol on myocardial necrosis induced by subcutaneous injection of isoprenaline in rats. A significant reduction (P < 0.01) of infarct size, polymorphonuclear cells and mast cells was observed in animals treated with policosanol at 5 or 25 mg kg-1, while animals receiving only acetysalicylic acid pretreatment showed a significant decrease in the infarct area (P < 0.05). No significant differences in polymorphonuclear and mast cells were obtained when compared with positive control data. It is concluded that policosanol delays the evolution of infarction, showing a protective effect on the myocardial necrosis induced by isoprenaline in this experimental model.

Isoproterenol‐induced cardiac ischemia and fibrosis: Plant‐based approaches for intervention

“…In addition to the abovementioned, multiple other extracts and traditional formulations have been investigated in ISP‐induced cardiotoxicity with promising protective effects (Wong et al, ). Some of these include Rhus tripartita extract (Shahat et al, ), maslinic acid (Hussain Shaik et al, ), isorhapontigenin (Abbas, ), sodium tanshinone IIA sulphonate (Wei et al, ), S‐allyl cysteine sulfoxide (Sangeetha & Quine, ), policosanol (Noa, Herrera, Magraner, & Mas, ), alatamine (Zhao et al, ), timosaponin B II (Deng et al, ), vanillic acid (Prince, Rajakumar, & Dhanasekar, ), icariin (Pan, Wang, Yang, Kong, & Wang, ), danshensu (Li et al, ), Muntingia calabura (Nivethetha, Jayasri, & Brindha, ), and Crataegus oxycantha (Jayalakshmi, Thirupurasundari, & Devaraj, ). A diagrammatic presentation of the main pathways inhibited by various phytoconstituents is presented in Figure .…”

Protective effects of octacosanol on 6-hydroxydopamine-induced Parkinsonism in rats via regulation of ProNGF and NGF signaling

“…For example, octacosanol attenuated disrupted hepatic reactive oxygen species (ROS) metabolism associated with acute liver injury progression in CCl 4 -intoxicated rats [33] . Additionally, Policosanol showed a protective effect on the myocardial necrosis induced by isoprenaline in a rat experimental model [34] . Results of another study proved an antiischemic effect of policosanol administered after induction of cerebral ischemia, in two different experimental models in Mongolian gerbils, suggesting a possible therapeutic effect in cerebral vascular disorders [35] .…”