Effect of poly(lactic-co-glycolic acid) blend ratios on the hydrolytic degradation of poly(para-dioxanone)

Liu, Xiliang; Hou, Peijie; Liu, Song; Qi, Jia; Feng, Shaomin; Zhang, Lifang; Packham, MA; Bai, Wei

doi:10.1007/s10965-021-02529-7

Cited by 10 publications

(5 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As the research on marine plastic pollution developed further, the degradability and security of biodegradable plastics in seawater received worldwide concerns. − Because seas and oceans are characterized by lower average temperature, less illumination, and fewer microbial communities per unit volume, traditional biodegradable plastics, such as PBS and PLA, which normally have superior degradation properties in soil and/or compost, degrade more slowly in marine environments. − In a previous study, our group compared and summarized seawater degradability of several types of commercial biodegradable polymers and observed that PLA hardly degraded in 1 year, whereas the weight loss of PBS and PBAT was only 2% after 52 weeks of degradation in natural seawater, which was consistent with the findings of other research studies. , In attempts to develop polymers that are degradable in marine environments, many researchers have introduced water-soluble poly(vinyl alcohol) (PVA), , biodegradable starch, , and easily hydrolyzed poly(lactic- co -glycolic acid) (PLGA) into biodegradable resin matrices via blending, hoping that the overall degradation rates of resin materials in seawater can be improved by the rapid dissolution and departure of easily hydrolyzed or water-soluble components. However, the results were not as good as expected, and the seawater degradation rates of resin matrices were not effectively improved.…”

Section: Introductionmentioning

confidence: 99%

“…14−16 In a previous study, our group compared and summarized seawater degradability of several types of commercial biodegradable polymers and observed that PLA hardly degraded in 1 year, whereas the weight loss of PBS and PBAT was only 2% after 52 weeks of degradation in natural seawater, 17 which was consistent with the findings of other research studies. 15,18 In attempts to develop polymers that are degradable in marine environments, many researchers have introduced water-soluble poly(vinyl alcohol) (PVA), 19,20 biodegradable starch, 21,22 and easily hydrolyzed poly(lactic-coglycolic acid) (PLGA) 23 into biodegradable resin matrices via blending, hoping that the overall degradation rates of resin materials in seawater can be improved by the rapid dissolution and departure of easily hydrolyzed or water-soluble components. However, the results were not as good as expected, and the seawater degradation rates of resin matrices were not effectively improved.…”

Section: ■ Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Biobased Seawater-Degradable Poly(butylene succinate-l-lactide) Copolyesters: Exploration of Degradation Performance and Degradation Mechanism in Natural Seawater

Liu

Huang

et al. 2022

ACS Sustainable Chem. Eng.

View full text Add to dashboard Cite

In view of the problem of marine plastic pollution and oil resource depletion, an innovative attempt was made to obtain biobased seawater-degradable polyesters by installing lactic acid (LA) into the poly(butylene succinate) (PBS) backbone and synthesizing a series of random copolyesters named poly(butylene succinate-L-lactide)s (PBSLs). Herein, biobased LA units are chosen as readily hydrolyzable points according to our theoretical calculation. The obtained PBSL copolyesters preserve the structure of PBS when LA units are inserted into this main chain mostly with a single unit. While maintaining excellent mechanical and thermal properties, PBSL shows notably improved degradation performance during a 440-day long-term test in natural seawater compared to PBS, demonstrating rapid loss of weight and mechanical properties, as well as a decrease in the molecular weight. A highly sensitive system for end-product CO 2 detection during the seawater degradation process is designed and applied for the first time under conditions close to the natural seawater environment. A record mineralization rate of 16.2% in seawater after 379 days of degradation is achieved for PBSL30, which proved the occurrence of biodegradation in seawater. This result, combined with the analysis of intermediate products, clearly explained the whole degradation mechanism of PBSLs in seawater.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Biobased Seawater-Degradable Poly(butylene succinate-l-lactide) Copolyesters: Exploration of Degradation Performance and Degradation Mechanism in Natural Seawater

Liu

Huang

et al. 2022

ACS Sustainable Chem. Eng.

View full text Add to dashboard Cite

show abstract

“…As PDO threads are biodegradable, changes in the strength retention rate were confirmed as they decomposed over time in vitro. 9,16,28,29 The diameter and tensile strength of the coated and uncoated threads satisfied the adequacy criteria for USP 2. Furthermore, coated and uncoated threads exhibited high retention rates of tensile strength, which remained at ≥92% after 14 days and ≥85% after 28 days, according to the initial values.…”

Section: Discussionmentioning

confidence: 93%

“…14 Amino acids have stimulated protein synthesis in multiple in vivo and in vitro studies. 14,16,17 Glycine (Gly) and L-proline (Pro) account for 57% of the total AAs in collagen, accounting for one-third of animal proteins. Collagen and elastin are rich in Gly and Pro, and an adequate supply of these AAs is essential for collagen synthesis.…”

mentioning

confidence: 99%

Evaluation of Physical Properties of Coated Polydioxanone Threads

Park,

Jang,

Kim

2024

Dermatol Surg

View full text Add to dashboard Cite

BACKGROUND Using a thread for wound closure promotes healing and minimizes contamination by foreign substances. Threads have also been employed in esthetic surgery; however, functional threads that can improve wrinkles and rejuvenate the skin are required. OBJECTIVE To evaluate the suitability of polydioxanone threads coated with polyethylene glycol, hyaluronic acid, and amino acids for use in the medical field because such formulations are expected to promote regeneration and collagen synthesis. MATERIALS AND METHODS Physical properties (diameter [n = 20], tensile strength [n = 20], strength retention rate [n = 10], and scanning electron microscopy images) and cytotoxicity (3-[4,5-dimethylthiazol-2-yl]–2,5-diphenyltetrazolium bromide and lactate dehydrogenase assays) of polydioxanone threads coated with polyethylene glycol, hyaluronic acid, and amino acids were assessed and compared with those of uncoated polydioxanone threads. Analyses were performed using IBM SPSS Statistics (Statistical significance; p values <.05). RESULTS The size standards for tensile strength (≥63.5 N) and diameter (average 0.570–0.610 mm) were met. There were no differences in the physical properties of the coated and uncoated threads; however, the biocompatibility of coated threads was high owing to low cytotoxicity. CONCLUSION Threads coated with materials that can promote regeneration are suitable for use in the medical field.

show abstract

“…In the case of synthetic polymers such as poly-ε-caprolactone (PCL), hydrolysis is considered the most important degradation mechanism, which strongly depends on the type of chemical bonds, copolymer composition and wettability properties [ 21 , 22 , 23 , 24 , 25 ]. This degradation mechanism involves the hydrolysis of unstable ester bonds present in the molecular chain of the polymer [ 26 , 27 , 28 , 29 , 30 ]. Moreover, as these polymers are semi-crystalline materials, it has been pointed out that the degradation occurs through a random hydrolytic split of the amorphous regions followed by the gradual degradation of the crystalline regions [ 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ].…”

Section: Introductionmentioning

confidence: 99%

Accelerated Degradation of Poly-ε-caprolactone Composite Scaffolds for Large Bone Defects

et al. 2023

View full text Add to dashboard Cite

This research investigates the accelerated hydrolytic degradation process of both anatomically designed bone scaffolds with a pore size gradient and a rectangular shape (biomimetically designed scaffolds or bone bricks). The effect of material composition is investigated considering poly-ε-caprolactone (PCL) as the main scaffold material, reinforced with ceramics such as hydroxyapatite (HA), β-tricalcium phosphate (TCP) and bioglass at a concentration of 20 wt%. In the case of rectangular scaffolds, the effect of pore size (200 μm, 300 μm and 500 μm) is also investigated. The degradation process (accelerated degradation) was investigated during a period of 5 days in a sodium hydroxide (NaOH) medium. Degraded bone bricks and rectangular scaffolds were measured each day to evaluate the weight loss of the samples, which were also morphologically, thermally, chemically and mechanically assessed. The results show that the PCL/bioglass bone brick scaffolds exhibited faster degradation kinetics in comparison with the PCL, PCL/HA and PCL/TCP bone bricks. Furthermore, the degradation kinetics of rectangular scaffolds increased by increasing the pore size from 500 μm to 200 μm. The results also indicate that, for the same material composition, bone bricks degrade slower compared with rectangular scaffolds. The scanning electron microscopy (SEM) images show that the degradation process was faster on the external regions of the bone brick scaffolds (600 μm pore size) compared with the internal regions (200 μm pore size). The thermal gravimetric analysis (TGA) results show that the ceramic concentration remained constant throughout the degradation process, while differential scanning calorimetry (DSC) results show that all scaffolds exhibited a reduction in crystallinity (Xc), enthalpy (Δm) and melting temperature (Tm) throughout the degradation process, while the glass transition temperature (Tg) slightly increased. Finally, the compression results show that the mechanical properties decreased during the degradation process, with PCL/bioglass bone bricks and rectangular scaffolds presenting higher mechanical properties with the same design in comparison with the other materials.

show abstract

Effect of poly(lactic-co-glycolic acid) blend ratios on the hydrolytic degradation of poly(para-dioxanone)

Cited by 10 publications

References 36 publications

Biobased Seawater-Degradable Poly(butylene succinate-l-lactide) Copolyesters: Exploration of Degradation Performance and Degradation Mechanism in Natural Seawater

Biobased Seawater-Degradable Poly(butylene succinate-l-lactide) Copolyesters: Exploration of Degradation Performance and Degradation Mechanism in Natural Seawater

Evaluation of Physical Properties of Coated Polydioxanone Threads

Accelerated Degradation of Poly-ε-caprolactone Composite Scaffolds for Large Bone Defects

Contact Info

Product

Resources

About