Effect of polymer coating characteristics on the biodegradation and biocompatibility behavior of magnesium alloy

Research progress of metal biomaterials with potential applications as cardiovascular stents and their surface treatment methods to improve biocompatibility

“…However, compared to metallic and ceramic materials, polymer-based materials have limited mechanical properties and can barely be directly used in an unmodified state [ 136 ]. Anil et al [ 137 ] developed two polymer coatings consisting of polycaprolactone (PCL) and poly-ω-pentavalerolactone (PPDL) on a magnesium surface, to address the issue of magnesium rapidly disintegrating in vivo and enhancing its potential application as a cardiovascular stent. The results showed that the polymer coatings notably strengthened the corrosion resistance of magnesium and the corrosion resistance increased with polymer coating thickness.…”

Effect of multi‐axial hot forging process on mechanical, and corrosion resistance behavior of Mg‐3Zn alloy for temporary orthopedic implants

“…In this regard, researchers have performed the initial in‐vitro evaluation of cytotoxicity of bare Mg as well as surface‐modified Mg alloys using bone marrow cells of mice. This initial assessment shows positive cell proliferation and viability even after 72 hours of incubation with Mg alloys, as well as no indication of growth inhibition 7 . Additionally, the biodegradable nature of Mg and its alloys would be an extra benefit, as fracture‐fixing accessories would be completely replaced by new growing tissue.…”

“…It has also been reported that dissimilarity in elastic modulus of metallic implants and bone tissue caused the stress-shielding. 7,8 The elastic modulus of Mg (∼45 GPa) is close to the natural bone tissue (∼30 GPa), which is approximately half of the elastic modulus of Ti6Al4V alloy (109-112 GPa). 8 Mg has the great potential to replace the widely used Ti6Al4V if the corrosion rate can be adapted to simulate the bone growth rate.…”

“…9 In this context, the presence of active bivalent ions (Mg 2+ ) in Mg-based materials supports the apatite layer formation in the physiological environment. 7 Apart from that, Mg implanted alumina (Al 2 O 3 ), by an ion implantation procedure, enhanced adhesion as well as differentiation of the human cells when compared to non-coated alumina. 10 Mg 2+ ion is extensively found inside the human body without any trace of harmful effects.…”

“…This initial assessment shows positive cell proliferation and viability even after 72 hours of incubation with Mg alloys, as well as no indication of growth inhibition. 7 Additionally, the biodegradable nature of Mg and its alloys would be an extra benefit, as fracture-fixing accessories would be completely replaced by new growing tissue.…”