Effect of polymer compositions on the fabrication of poly(<i>ortho</i>‐ester) microspheres for controlled release of protein

Bai, Xiao-Bo; Yang, Yi-Yan; Chung, Tai‐Shung; Ng, Shu Hang; Heller, Jorge

doi:10.1002/app.1257

Cited by 18 publications

(6 citation statements)

References 23 publications

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“…The hydrophobicity of the polymer is influenced by the ratio of amorphous to crystalline regions, which in turn is determined by the latent acid group [lactic acid or glycolic acid]. Lactic acid, being more hydrophobic than glycolic acid, makes POE with d , l -lactide more hydrophobic and subsequently slows down the degradation process. , Therefore, by adjusting the lactide/POE ratio, the desired degradation rate and, subsequently, release pattern of the drug can be achieved …”

Section: Resultsmentioning

confidence: 99%

Poly(ortho ester) Nanoparticle-Based Targeted Intraocular Therapy for Controlled Release of Hydrophilic Molecules

Palamoor

Jablonski

2013

Mol. Pharmaceutics

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Development of an efficient intraocular drug delivery nanosystem remains the most difficult challenge to attain a prolonged therapeutic effect at the site of drug action. The purpose of this work was to develop a biodegradable, long-term sustained release, and biocompatible nanoparticulate system to treat various intraocular diseases. To attain the objectives, poly(ortho ester) (POE), a hydrophobic, surface erodible, and nontoxic polymer, was selected for fabrication of nanoparticles for the first time using a double emulsion solvent evaporation method. The influence of POE molecular weight on particle size, polydispersity index, zeta potential, drug content, in vitro release, degradation, in vitro cytotoxicity, and cell uptake studies was investigated. Drug-loaded nanoparticles had a spherical shape with an average particle diameter from 241 to 298 nm and zeta potential values from -8 to -11 mV. Encapsulation efficiency ranged between 21 and 63%, depending on the type of the water-soluble molecule used. Approximately 20-30% of the loaded drug was released over a period of 14 weeks. The drug release and degradation profiles of nanoparticles followed perfect zero-order kinetics confirming the POE-surface erosion mechanism. In vitro cytotoxicity and cell uptake studies revealed the cyto-compatible nature and nonendocytic behavior of POE nanoparticles. Collectively, POE nanoparticles are a very promising vehicle for sustained delivery of therapeutics to the back of the eye.

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Section: Resultsmentioning

confidence: 99%

Poly(ortho ester) Nanoparticle-Based Targeted Intraocular Therapy for Controlled Release of Hydrophilic Molecules

Palamoor

Jablonski

2013

Mol. Pharmaceutics

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“…Microspheres can be formed by the evaporation of an organic solvent from dispersed oil droplets containing both the polymer and the drug [26][27][28][29][30][31][32]. Often, a double emulsion is employed; first the drug for encapsulation is dissolved in water; this aqueous phase is dispersed in an organic solvent, usually dichloromethane (or chloroform or ethyl acetate), which contains the degradable polymer and the primary water-in-oil (w/o) emulsion is formed.…”

Section: Solvent Evaporation Methodsmentioning

confidence: 99%

Mucoadhesive Microspheres: A Promising Tool in Drug Delivery

Patil

Sawant²

2008

CDD

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Mucoadhesive polymers have recently gained interest among pharmaceutical scientists as a means of improving drug delivery by promoting the residence time and contact time of the dosage form with the mucous membranes. Mucoadhesion is the process whereby synthetic and natural polymers adhere to mucosal surfaces in the body. If these materials are then incorporated into pharmaceutical formulations, drug absorption by mucosal cells may be enhanced or the drug will be released at the site for an extended period of time. Microspheres, in general, have the potential to be used for targeted and controlled release drug delivery; however, coupling of mucoadhesive properties to microspheres has additional advantages like, a much more intimate contact with the mucus layer, efficient absorption and enhanced bioavailability of the drugs due to a high surface to volume ratio. The present review describes the potential applications of mucoadhesive microspheres as a novel carrier system to improve drug delivery by various routes of administration like buccal, oral, nasal, ocular, vaginal and rectal, either for systemic or for local effects. The mucoadhesive polymers, methods of preparation of microspheres and their in vitro and in vivo evaluation are also described.

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“…Afterwards it is further decomposed to carbon dioxide and water (Houchin and Topp 2009). Microspheres of PLGA and other polymers are usually formed by solvent evaporation (Wakiyama et al 1981;Bai et al 2001;Ruan and Feng 2003). Frequently a double emulsion is used in which medicament that will be encapsulated is primarily dissolved in water.…”

Section: Poly(lactic-co-glycolic Acid) Microparticlesmentioning

confidence: 99%

Sustained drug delivery system in fish and the potential for use of PLGA microparticles: a review

Matejkova¹,

Podhorec²

2019

Vet. Med. - Czech

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Many fish species display some form of reproductive disorder in captivity. Captive fish reared in conditions outside the natural spawning environment show a failure of the pituitary to release the maturational gonadotropin luteinizing hormone thus necessitating administration of the hormone to induce spawning. A controlled sustained-release delivery system can conquer the issue of short half-life of gonadotropin releasing hormone (GnRH) in blood and avoid the necessity of using re-injections. Sustained release of GnRHa can induce long-term enhancement in semen production and multiple spawning in species with asynchronous or multiple batch group synchronous ovarian physiology. The most recent development is the incorporation of GnRHa into microparticles of biodegradable polymers that release the drug during a certain period of time ranging from days to weeks. The most attractive polymeric candidate used as a carrier for administering a pharmaceutical products is poly(lactic-co-glycolic acid); (PLGA). PLGA has excellent biodegradability and biocompatibility and is generally recognised as safe by international regulatory agencies including the European Medicines Agency and the United States Food and Drug Administration. This review describes methods of hormonal treatment in fish, highlights the advantage of sustained drug delivery system and discusses the potential of PLGA microparticles as a tool for achieving successful reproduction.

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Effect of polymer compositions on the fabrication of poly(ortho‐ester) microspheres for controlled release of protein

Cited by 18 publications

References 23 publications

Poly(ortho ester) Nanoparticle-Based Targeted Intraocular Therapy for Controlled Release of Hydrophilic Molecules

Poly(ortho ester) Nanoparticle-Based Targeted Intraocular Therapy for Controlled Release of Hydrophilic Molecules

Mucoadhesive Microspheres: A Promising Tool in Drug Delivery

Sustained drug delivery system in fish and the potential for use of PLGA microparticles: a review

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