Effect of Polymers on Dissolution from Drug Suspensions

Shah, Nutan B.; Sheth, Bhogi B.

doi:10.1002/jps.2600651114

Cited by 29 publications

(7 citation statements)

References 2 publications

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“…Aqueous solution of KT and various test niosomes prepared were subjected to release studies using a dissolution-dialysis apparatus fabricated in our laboratory, which is a modified version of the dissolution-dialysis assembly of Shah and Sheth (28). The dissolution cell consisted of a hollow glass cylinder (length 14.6 cm and internal diameter 2.5 cm) made up of Borosil glass.…”

Section: Zeta Potential Measurementmentioning

confidence: 99%

Release Studies on Niosomes Containing Fatty Alcohols as Bilayer Stabilizers Instead of Cholesterol

Devaraj

Parakh

Devraj

et al. 2002

Journal of Colloid and Interface Science

151

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Section: Zeta Potential Measurementmentioning

confidence: 99%

Release Studies on Niosomes Containing Fatty Alcohols as Bilayer Stabilizers Instead of Cholesterol

Devaraj

Parakh

Devraj

et al. 2002

Journal of Colloid and Interface Science

151

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“…Moreover the results showed that the presence of sodium alginate retarded the dissolution rate of loratadine at all concentrations used. This result is related to the formation of higher viscosity regions due to the hydrated polymer surrounding drug particles which encounter high resistance to the dissolution (23) . On the other hand, the effect of veegum on the dissolution rate of loratadine is shown in figure (5).…”

Section: Effect Of Type and Concentration Of Suspending Agent On The ...mentioning

confidence: 99%

“…However, formula B had a sedimentation volume equal to 0.6 and was easily resuspended by shaking. This low sedimentation volume may be due to the type of the suspending agent used, since NaCMC may form homogenous network in all concentrations used (23) . On the other hand, formula E, which showed sedimentation during the test period, had low sedimentation volume of 0.4 and was resuspendable with difficulty, so it is pharmaceutically unacceptable.…”

Section: Sedimentation Volume and Resuspendabilitymentioning

confidence: 99%

Some Variables Affecting the Formulation of Oral Loratadine Suspension

S.Yousif¹,

Khalil²

2017

IJPS

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Loratadine is a long acting non-sedating anti-histaminic agent that was developed for the treatment of seasonal allergic rhinitis, whose anti-histaminic action is more effective than the other anti-histaminic drugs available commercially. This project was carried out to prepare an acceptable suspension through studying the release of drug in presence of different types and concentrations of suspending agents such as polysorbate 40, xanthan gum, sodium carboxymethylcellulose (NaCMC), aluminum magnesium silicate (veegum) and sodium alginate. The effects of these suspending agents were studied at pH 1.2 (0.1N HCl) and 37 Ù’C. The results showed that the release rate of loratadine in the presence of these suspending agents was dependent on their types and concentrations. The results showed that loratadine release from the formula prepared from xanthan gum is more than that prepared from other polymers in the following order: Sodium alginate < NaCMC < veegum < xanthan gum. However, elegancy of suspension was better on using xanthan gum in a concentration of 0.5%. The obtained results were utilized to formulate 0.1% suspension of loratadine which is physically stable with an optimum drug release. The rheology, sedimentation volume, resuspendability and expiration date were evaluated for the selected formula. The formula that contains loratadine, xanthan gum, glycerol, sorbitol, methyl paraben, propyl paraben, sodium edetate, raspberry flavor at pH 5.0 appears to be a promised formula to be present with estimated shelf life of about 3.8 years. Key word: loratadine, suspension, suspending agent, xanthan gum

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“…Formula -III after reconstitution showed lower dissolution profile than formula Hand zithromax ® , this may be due to the granulation process, since PVP was used as a granulating agent which is water soluble binder and has good swelling and hydration capacity. These properties result in the high viscous region surrounding the drug particle (29,30) .On the other hand the viscosities of the products are represented in table (3). The results showed that the viscosity of azithromycin suspension was shear rate dependent and increased viscosity in the following order: Azionce ® > Zithromax ® > Formula -H > Formula -III Table (4,5) show the sedimentation volume and resuspendability after settling of the chosen azithromycin formulas (H,III) and the reference suspensions after 48 hours undisturbing .…”

Section: Formulasmentioning

confidence: 99%

Formulation of Azithromycin Suspension as an Oral Dosage Form

Jaber¹,

T.Salih²,

Salmo³

2017

IJPS

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Azithromycin is the drug of choice in the treatment of several bacterial infections, most often those causing middle ear infection, bronchitis, pneumonia, typhoid and sinusitis. Itâ€™s also effective against certain urinary tract infections and venereal diseases. This study was carried out to prepare an acceptable suspension either as dry physical mixture powder or granules to be reconstituted, through studying the effect of various type and concentration of suspending agent (xanthan gum, hydroxypropyl methylcellulose (HPMC), either alone or in combination) on the release profile of the drug. The best prepared suspension formulas (H& III) were selected depending on the dissolution profile of each formulas and then compared with the reference suspensions (Zithromax and Azi-once).The viscosity, sedimentation volume, Resuspendability and expiration date were evaluated for the chosen formulas (H&III) and compared with references ZithromaxÃ’ and Azi-onceÃ’.The result indicated that the chosen formula â€“ H had better dissolution rate compared with references suspensions, Also it was less viscous than them.While other chosen formula â€“ III had lower dissolution rate compared with ZithromaxÃ’ and higher dissolution rate than AZi â€“ once, also it was less viscous than both references.It was found that the dry physically mixed powder (formula â€“ H) was more stable than the granular suspension (Formula III) since the expiration date for formula H and formula III were 3.24 and 2.7 years respectively. Key words: Azithromycin, suspending agent, suspension.

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Effect of Polymers on Dissolution from Drug Suspensions

Cited by 29 publications

References 2 publications

Release Studies on Niosomes Containing Fatty Alcohols as Bilayer Stabilizers Instead of Cholesterol

Release Studies on Niosomes Containing Fatty Alcohols as Bilayer Stabilizers Instead of Cholesterol

Some Variables Affecting the Formulation of Oral Loratadine Suspension

Formulation of Azithromycin Suspension as an Oral Dosage Form

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