Effect of Polymers on the Physicochemical and Drug Release Properties of Transdermal Patches of Atenolol

Kumar, Manish; Trivedi, Vishal; Shukla, Ajay Kumar; Dev, Suresh Kumar

doi:10.22159/ijap.2018v10i4.24916

Cited by 14 publications

(10 citation statements)

References 16 publications

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“…Tensile strength = 0.329917+0.000540* HPMC 50 cps-0.000088* Ethylcellulose+0.004556* Almond oil. [15]. The linear equation generated by the software is given below:…”

Section: Resultsmentioning

confidence: 99%

Optimization and Preparation of Solid Lipid Nanoparticle Incorporated Transdermal Patch of Timolol Maleate Using Factorial Design

Kumar¹,

Shrivastava²,

Gupta³

et al. 2019

Int J App Pharm

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Objective: Transdermal patch of timolol maleate was prepared in order to increase the permeability of the drug topically. Methods: The timolol maleate (TM) loaded solid lipid nanoparticles (SLN) were prepared by the solvent evaporation method. For the optimization process full factorial (three-factor and three-level), hydroxypropyl methylcellulose (HPMC) range from 100 to 300 mg, ethylcellulose 100 to 200 gm and almond oil 3 to 4 ml. The response noted in form of tensile strength and percent drug release. These transdermal patches were evaluated for physical characterization like weight variation, thickness, percentage moisture absorption, percentage moisture loss, water vapor transmission rate, folding endurance, tensile strength, and content uniformity. Results: Solid lipid nanoparticles of TM were optimized and prepared, the data presented that drug release percent ranged from 66.12 to 91.75. 2FI model was observed to fit for response % drug permeation with a p and F value of 0.0271 and 4.50. The tensile strength varies from 0.358 to 0.508. The linear model was observed to fit for the tensile strength response with a p-value and F-value of<0.0001 and 52.41. Conclusion: The controlled release formulation of Timolol Maleate was successfully optimized and prepared, a study conducted to investigate the effect of different polymers and type of permeation time profiles from Timolol Maleate patches.

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“…Tensile strength = 0.329917+0.000540* HPMC 50 cps-0.000088* Ethylcellulose+0.004556* Almond oil. [15]. The linear equation generated by the software is given below:…”

Section: Resultsmentioning

confidence: 99%

Optimization and Preparation of Solid Lipid Nanoparticle Incorporated Transdermal Patch of Timolol Maleate Using Factorial Design

Kumar¹,

Shrivastava²,

Gupta³

et al. 2019

Int J App Pharm

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“…An optimum proportion of hydrophilic and hydrophobic polymer was required to prepare effective transdermal patches. 22 Mahdie Torkaman et al, (2017) 33 observed that there were considerable numbers of medicines that cannot be dissolved in water or had a little aqueous solubility, which caused problems in their absorption and reduction of bioavailability of them subsequently. Various methods have been developed to increase the solubility of drugs to treat these problems.…”

Section: Usingmentioning

confidence: 99%

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2022

IJPSR

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Cancer refers to a group of diseases characterized by abnormal, unchecked cell growth that spreads to other body parts. Breast, liver, colorectal, kidney, stomach, lungs, and cervical cancer are the most common tumours, with skin cancer (excluding melanoma) being the least common (contributing up to 40 percent of the cases). Surgery, chemotherapy, and other traditional medical methods have several negative side effects, including extreme inflammation and discomfort. As a result, transdermal delivery of the anticancer drug transdermal patch may be beneficial for treating multiple breast cancers via the skin. Transdermal drug penetration using various methods, such as nanocarriers, tactile penetration enhancing tools, chemical penetration enhancers, and newer innovations, such as gels, dendrimers, needle-free injection jets and so on, results in increased patient compliance, scar elimination, and economic benefit. Topical antineoplastic drug delivery is a popular option for increasing site-specific delivery, mitigating side effects, and enhancing therapeutic effects. This study aims to discuss the transdermal delivery of anticancer agents via the skin, which can open up a new frontier in cancer care using nanocarriers. INTRODUCTION:Cancer: Cancer is a broad term for a group of diseases characterized by uncontrolled cell growth that spreads throughout the body. The most common cancers are lung, liver, colorectal, prostate, thyroid, breast, and cervical cancers, with skin cancer (excluding melanoma) being the least common (contributing up to 40 percentage of the cases). Surgery and chemotherapy, for example, have many unpleasant side effects, including severe inflammation and discomfort. New transdermal procedures and methods have been established by QUICK RESPONSE CODE

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“…Accurately weighed 10 mg of drug was dissolved in 10 ml of 7.4 pH buffer solution in 10 ml of volumetric flask (Kumar et al 2018). The resulted solution 1000μg/ml and from this solution 1 ml pipette out and transfer into 10 ml volumetric flask and volume make up with 7.4 pH buffer solution prepare suitable dilution to make it to a concentration range of 5-25 μg/ml.…”

Section: Determination Of λMax Of Tazarotenementioning

confidence: 99%

Formulation development and evaluation of Transferosomal drug delivery for effective treatment of acne

Shah¹,

Khan²,

Maurya³

et al. 2019

Adv Pharm J

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Objective: The objective of the present work was to formulation, development and evaluation of transferosomal drug delivery for effective treatment of acne. Soya phosphatidyl choline, sodium cholate, Tazarotene, ethanol and Materials and Methods: all chemicals and reagents used were of analytical grade. Different formulation (F-1 to F-8) of transfersomes were Results: prepared and evaluated for vesicle size and entrapment efficiency. The vesicle size of all transfersomes varied between 155.2 and 262.1nm where as entrapment efficiency was found between 60.12 to 75.65%. Results showed that in formulation F4 which contain smallest vesicle size and increase in entrapment efficiency, Formulation F4 selected as optimized formulation and further incorporated into gel base (TF1, TF2, TF4) and evaluated for Drug content, pH, Spreadibility, Viscosity measurements and drug release study. Transfersomes gel released drug in controlled release manner in 12 hour but in case of marketed In-vitro formulation there is no controlled release of drug from gel. The developed of Tazarotene as transfersomal gel has Conclusion: the ability to overcome the barrier properties of the skin and increase the drug release

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Effect of Polymers on the Physicochemical and Drug Release Properties of Transdermal Patches of Atenolol

Cited by 14 publications

References 16 publications

Optimization and Preparation of Solid Lipid Nanoparticle Incorporated Transdermal Patch of Timolol Maleate Using Factorial Design

Optimization and Preparation of Solid Lipid Nanoparticle Incorporated Transdermal Patch of Timolol Maleate Using Factorial Design

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Formulation development and evaluation of Transferosomal drug delivery for effective treatment of acne

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