Effect of polyphenols on the intestinal and placental transport of some bioactive compounds

Abstract

Polyphenols are a group of widely distributed phytochemicals present in most foods of vegetable origin. A growing number of biological effects have been attributed to these molecules in the past few years and only recently has their interference with the transport capacity of epithelial barriers received attention. This review will present data obtained concerning the effect of polyphenols upon the transport of some compounds (organic cations, glucose and the vitamins thiamin and folic acid) at the intestinal and placental barriers. Important conclusions can be drawn: (i) different classes of polyphenols affect transport of these bioactive compounds at the intestinal epithelia and the placenta; (ii) different compounds belonging to the same phenolic family often possess opposite effects upon transport of a given molecule; (iii) the acute and chronic/short-term and long-term exposures to polyphenols do not produce parallel results and, therefore, care should be taken when extrapolating results; (iv) the effect of polyphenolics in combination may be very different from the expected ones taking into account the effect of each of these compounds alone, and so care should be taken when speculating on the effect of a drink based on the effect of one component only; (v) care should be taken in drawing conclusions for alcoholic beverages from results obtained with ethanol alone. Although most of the data reviewed in the present paper refer to in vitro experiments with cell-culture systems, these studies raise a concern about possible changes in the bioavailability of substrates upon concomitant ingestion of polyphenols.

Effects of Wine by-Products on Growth Performance, Complete Blood Count and Total Antioxidant Status in Broilers

“…Our results are comparable with those obtained by Goñi et al (2007) at the age of 21 days, respectively Brenes et al (2008) In general, the effect of polyphenolic compounds on the absorption and assimilation of different nutrients depends on many different factors including the type of compounds, its dosage, combination with other compounds, etc (Martel et al, 2010). Significant growth depression was observed with the use of grape seed extract that was reported by Hughes et al (2005) and Lau & King (2003).…”

Effects of grape pomace and vitamin E on performance, antioxidant status, immune response, gut morphology and histopathological responses in broiler chickens

“…In general, many different factors, including type of compounds, its dosage and combination with other compounds, can affect the effects of polyphenol compounds on digestion, absorption and metabolism of different nutrients (Martel et al, 2010). Thus, in this study, we used different level of GP and all diets were formulated with same fiber content.…”

Anti-diabetic actions of Berry polyphenols – Review on proposed mechanisms of action

“…Most of the in vitro studies are conducted with individual polyphenolic compounds that are commonly available in berry fruits [41]. Catechins and quercetin-3-O-glucoside were found to inhibit the transport activity of SGLT1 [42]. A study by Manzano and Williamson, [43] using Caco-2 intestinal cell monolayers showed that strawberry polyphenols, phenolic acids and tannins inhibit glucose transport from the intestinal lumen into cells and also the GLUT2-facilitated exit on the basolateral side.…”