Effect of polyunsaturated phosphatidylcholine on lipid structure and cAMP-dependent signal transduction in the liver of rats chronically intoxicated with ethanol

A low dose of ionizing radiation increases luminal release of intestinal peptidases in rats

“…Environmental in¯uences, contamination and radiation are capable of injuring the mucosa of the small intestine and, subsequently, altering its membrane composition of enzymes and lipids within the brush border (Richter et al 1997;Becciolini et al 1976Becciolini et al , 1987HuÈ tter 1990, 1992;Buko et al 1994;Keelan et al 1989;Taraschi and Rubin 1985). Ionizing radiation-induced alterations of the mucosa (Becciolini et al 1972(Becciolini et al , 1973(Becciolini et al , 1976Langberg et al 1994) cause a disturbance in cell membrane structure, yielding``leaky'' membranes that fail to retain cell-speci®c enzymatic activity.…”

Protective effect of oral phosphatidylcholine on radiation-induced release of intestinal peptidases in rats

“…in a dose of 100 and 300 mg/kg b.w., respectively, by Buko et al (1994) and Dargel et al (1991). Other authors (Kuntz 1991;Lekim and Graf 1976) have also been shown a protective eect of PPC in a lower daily dosage; for instance, 10, 25, 40, and 70 mg PPC/kg b.w., respectively.…”

“…Membrane damage always means cell damage (Kuntz 1991) and consequently the membrane function is impaired (Buko et al 1994;Poon et al 1981;Homann et al 1982;Tagesson et al 1985). Therefore, the incorporation of exogenous phosphatidylcholine is decisive for the restoration of the morphology and function of biological membranes (Anand et al 1999;Kuntz 1991).…”

“…The cytoprotective eect of these polyunsaturated substances has been demonstrated in several investigations (Anand et al 1999;Aleynik et al 1997;Buko et al 1994;Poon et al 1981;Kuntz 1991;Homann et al 1982;Dunjic et al 1993;Keelan et al 1990;Dargel et al 1991;Lekim and Graf 1976;Oette et al 1995).…”

Phosphatidylcholine does not protect rats against 5-fluorouracil/folinic acid-induced damage of the intestinal luminal mucosa

“…has a membrane-stabilizing effect on the intestinal mucosa of rats, which were injured by a single fraction of radiation (Fittkau et al 2001a). The cytoprotective effect of this polyunsaturated substance has been demonstrated in several experiments (Buko et al 1994(Buko et al , 1996Dunjic et al 1993;Oette et al 1995;Lieber et al 1994;Lieber 1997). ''Essential'' phospholipids constitute vital elements of biological membranes in cells and organelles.…”