Effect of polyvinyl alcohol concentration on biomedical application of chitosan/bioactive glass composite coated on AZ91D magnesium alloy

Vafa, Ehsan; Bazargan‐Lari, Reza; Bahrololoom, M.E.; Amani, Ali Mohammad

doi:10.1016/j.matchemphys.2022.126650

Cited by 29 publications

(10 citation statements)

References 49 publications

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“…The EPD coatings are evaluated in terms of their adhesive properties, relative quantification of deposited materials, and surface roughness. A tape test was conducted to evaluate the adhesion of the coatings over the substrate . The findings were assessed according to ASTM D3359 standards (Figure ).…”

Section: Resultsmentioning

confidence: 99%

Electrophoretic Deposition of 58S Bioactive Glass- Polymer Composite Coatings on 316L Stainless Steel: An Optimization for Corrosion, Bioactivity, and Cytocompatibility

Hadem,

Mitra,

Ojha

et al. 2024

ACS Appl. Bio Mater.

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This study presents a facile fabrication of 58S bioactive glass (BG)-polymer composite coatings on a 316L stainless steel (SS) substrate using the electrophoretic deposition technique. The suspension characteristics and deposition kinetics of BG, along with three different polymers, namely ethylcellulose (EC), poly(acrylic acid) (PAA), and polyvinylpyrrolidone (PVP), have been utilized to fabricate the coatings. Among all coatings, 58S BG and EC polymers are selected as the final composite coating (EC6) owing to their homogeneity and good adhesion. EC6 coating exhibits a thickness of ∼18 μm and an average roughness of ∼2.5 μm. Herein, EC6 demonstrates better hydroxyapatite formation compared to PAA and PVP coatings in simulated body fluid-based mineralization studies for a period of 28 days. Corrosion studies of EC6 in phosphate-buffered saline further confirm the higher corrosion resistance properties after 14 days. In vitro cytocompatibility studies using human placental mesenchymal stem cells demonstrate an increase in cellular viability, attachment, and higher proliferation compared to the bare SS substrate. EC6 coatings promote osteogenic differentiation, which is confirmed via the upregulation of the OPN and OCN genes. Moreover, the EC6 sample exhibits improved antibacterial properties against Escherichia coli and Staphylococcus aureus compared to the uncoated ones. The findings of this work emphasize the potential of electrophoretically fabricated BG−EC composite coatings on SS substrates for orthopedic applications.

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Section: Resultsmentioning

confidence: 99%

Electrophoretic Deposition of 58S Bioactive Glass- Polymer Composite Coatings on 316L Stainless Steel: An Optimization for Corrosion, Bioactivity, and Cytocompatibility

Hadem,

Mitra,

Ojha

et al. 2024

ACS Appl. Bio Mater.

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“…Volume fractions is related to the weight fractions and the densities of each component. GNP density was considered being equal to 2.2 g/cm 3 . The Young's moduli of matrix is experimentally measured by tensile tests on neat matrix, which was equal to 4991 MPa, while Young's moduli of filler value for GNP were taken from the scientific literature [63].…”

Section: Mechanical Propertiesmentioning

confidence: 99%

“…There is various type of polymers which is used in modern lives and industries such as automotive, bioengineering, biomedical, thermal, mechanical and so on [1][2][3][4][5]. Polylactide (PLA), also known as polylactic acid, is a biodegradable, semi-crystalline, or amorphous biopolymer made from renewable natural sources [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Compatibilization of Immiscible PA6/PLA Nanocomposites Using Graphene Oxide and PTW Compatibilizer for High Thermal and Mechanical Applications

et al. 2023

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The aim of this work is synthesis a novel nanocomposite containing Polylactide (PLA) and polyamide 6 (PA6) reinforced with graphene oxide (GO) and poly ethylene-butyl acrylate-glycidyl methacrylate) (PTW) compatibilizer during solvent-based method. For this purpose, GO was added to the nanocomposite with 0.1, 0.3, 0.5, 0.7 and 1 phr. Morphology, rheology and mechanical properties of nanocomposites were studied with scanning electron microscopy (SEM), transmission electron microscopy (TEM) and (DMTA) which showed rougher fracture surface due to the presence of compatibilizer and an increase in the amount of graphene oxide and better dispersion of graphene oxide. The results of experimental and theoretical studies of mechanical properties showed that increasing the concentration of graphene oxide in the presence of PTW improved the tensile strength, impact strength and tensile modulus in the PA6/PTW/PLA system. The study of rheological properties (according to the Carreau-Yasuda model) showed an increase in storage modulus and complex viscosity, which also confirmed the role of PTW compatibilizer in better GO dispersion. So, PA6/PTW/PLA is a good candidate for mechanical and high thermal applications.

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“…Through the delivery of oxygen and nutrients and interactions between osteocytes and endothelial cells, the vascular structure that develops in a bone defect stimulates the differentiation, migration, and bone formation of osteoprogenitor cells [ 273 , 325 , 328 ]. Bone development is impaired and delayed when vascularization is restricted or disrupted.…”

Section: Bone Regenerationmentioning

confidence: 99%

Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process

et al. 2022

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Angiogenesis is a vital biological process involving blood vessels forming from pre-existing vascular systems. This process contributes to various physiological activities, including embryonic development, hair growth, ovulation, menstruation, and the repair and regeneration of damaged tissue. On the other hand, it is essential in treating a wide range of pathological diseases, such as cardiovascular and ischemic diseases, rheumatoid arthritis, malignancies, ophthalmic and retinal diseases, and other chronic conditions. These diseases and disorders are frequently treated by regulating angiogenesis by utilizing a variety of pro-angiogenic or anti-angiogenic agents or molecules by stimulating or suppressing this complicated process, respectively. Nevertheless, many traditional angiogenic therapy techniques suffer from a lack of ability to achieve the intended therapeutic impact because of various constraints. These disadvantages include limited bioavailability, drug resistance, fast elimination, increased price, nonspecificity, and adverse effects. As a result, it is an excellent time for developing various pro- and anti-angiogenic substances that might circumvent the abovementioned restrictions, followed by their efficient use in treating disorders associated with angiogenesis. In recent years, significant progress has been made in different fields of medicine and biology, including therapeutic angiogenesis. Around the world, a multitude of research groups investigated several inorganic or organic nanoparticles (NPs) that had the potential to effectively modify the angiogenesis processes by either enhancing or suppressing the process. Many studies into the processes behind NP-mediated angiogenesis are well described. In this article, we also cover the application of NPs to encourage tissue vascularization as well as their angiogenic and anti-angiogenic effects in the treatment of several disorders, including bone regeneration, peripheral vascular disease, diabetic retinopathy, ischemic stroke, rheumatoid arthritis, post-ischemic cardiovascular injury, age-related macular degeneration, diabetic retinopathy, gene delivery-based angiogenic therapy, protein delivery-based angiogenic therapy, stem cell angiogenic therapy, and diabetic retinopathy, cancer that may benefit from the behavior of the nanostructures in the vascular system throughout the body. In addition, the accompanying difficulties and potential future applications of NPs in treating angiogenesis-related diseases and antiangiogenic therapies are discussed.

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Effect of polyvinyl alcohol concentration on biomedical application of chitosan/bioactive glass composite coated on AZ91D magnesium alloy

Cited by 29 publications

References 49 publications

Electrophoretic Deposition of 58S Bioactive Glass- Polymer Composite Coatings on 316L Stainless Steel: An Optimization for Corrosion, Bioactivity, and Cytocompatibility

Electrophoretic Deposition of 58S Bioactive Glass- Polymer Composite Coatings on 316L Stainless Steel: An Optimization for Corrosion, Bioactivity, and Cytocompatibility

Compatibilization of Immiscible PA6/PLA Nanocomposites Using Graphene Oxide and PTW Compatibilizer for High Thermal and Mechanical Applications

Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process

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