Effect of polyvinylpyrrolidone on the crystallinity and dissolution rate of solid dispersions of the antiinflammatory CI-987

Kearney, Albert S.; Gabriel, Dawn L.; Mehta, Surendra C.; Radebaugh, Galen W.

doi:10.1016/0378-5173(94)90192-9

Cited by 33 publications

(31 citation statements)

References 12 publications

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“…Briefly, in binary solid dispersions, different weight ratios of OA and PVPk30 (1:1, 1:3, 1:5, 1:7, 1:9) were dissolved in 20 mL absolute ethanol responding to 0.1 g OA, then the solvent was removed in a water bath at 60ºC. 18,19 The residues were dried in an oven at 50-C for 24 hours, then ground in a mortar and passed through a 154-μm sieve. The resultant granules were kept in a desiccator until further investigations.…”

Section: Preparation Of Solid Dispersionsmentioning

confidence: 99%

Improved dissolution of oleanolic acid with ternary solid dispersions

Liu

Wang

2007

AAPS PharmSciTech

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The purpose of this study was to enhance the dissolution of oleanolic acid by solid dispersions consisting of the drug, a polymeric carrier, and a surfactant. Binary solid dispersions consisting of oleanolic acid and polyvinylpyrrolidone were prepared for comparison. Polysorbate 80, a nonionic surfactant, was incorporated into binary solid dispersions as the third component to prepare ternary solid dispersions. Solid dispersions were characterized by differential scanning calorimetry, Fourier transform infrared spectroscopy, and dissolution tests. The crystallinization of OA was prohibited in solid dispersions. Both the binary and ternary solid dispersions enhanced the dissolution of OA. Moreover, the dissolution of ternary solid dispersion was faster compared with that of binary solid dispersion. Polysorbate 80 played an important positive role in dissolution of the solid dispersion.

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Section: Preparation Of Solid Dispersionsmentioning

confidence: 99%

Improved dissolution of oleanolic acid with ternary solid dispersions

Liu

Wang

2007

AAPS PharmSciTech

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“…SDs were prepared using polyethylene glycols (Khan and Jiabi, 1998), cellulose derivatives (Leuner and Dressman, 2000), polyvinyl pyrrolidone (Kearney et al, 1994;Heo et al, 2005), mannitol and urea (Okonogi et al, 1997). Recently new classes of compounds Gelucires are proposed, Gelucires are a family of semi-solid lipid excipients, characterised by numbers relating to their approximate melting point and hydrophilic-lipophilic balance value (HLB 1-18).…”

Section: Introductionmentioning

confidence: 99%

Solubility enhancement and physicochemical characterization of carvedilol solid dispersion with Gelucire 50/13

et al. 2011

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The objective of the study was enhancement of dissolution of poorly soluble carvedilol by solid dispersions (SDs) with Gelucire 50/13 using solvent evaporation method. The solubility of carvedilol showed linear increase with increasing concentrations of Gelucire indicating A(L) type solubility diagrams. SDs characterized for physicochemical characteristics using differential scanning calorimetry and X-ray diffractometry revealed transformation of crystalline form of drug to amorphous form which was confirmed by scanning electron micrographs. Further fourier transform infrared spectroscopy results suggested there is no drug carrier interaction. From the dissolution parameters such as mean dissolution time, dissolution efficiency and drug release rate, improved dissolution characteristics for SDs were observed compared with physical mixture and pure drug. Thus SDs of carvedilol in Gelucire 50/13 showed enhanced solubility and dissolution rate compared to pure drug.

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“…[5] The nanoemulsion, solid-lipid nanoparticle (SLN) and solid dispersion (SD) techniques have been used successfully to improve the solubility, dissolution rate and in vivo bioavailability of poorly soluble drugs. [1][2][3][4][5][6][7][8][9][10][11] Because of the poor aqueous solubility of CXB (5 g/mL) poses a dissolution-related absorption problem, [1] an attempt was made to improve the solubility as well as the dissolution of CXB using various techniques like nanoemulsion, SLN and SD.…”

Section: Introductionmentioning

confidence: 99%

Nanoemulsion: A promising tool for solubility and dissolution enhancement of celecoxib

Shakeel

Faisal

2010

Pharmaceutical Development and Technology

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The solubility and dissolution of the poorly soluble drug celecoxib (CXB) was enhanced using many techniques like nanoemulsion, solid lipid nanoparticle and solid dispersion in the present investigation. The solubility of CXB in each formulation was determined using the reported HPLC method at the wavelength of 250 nm. Dissolution studies of pure CXB and its formulations were performed using USP dissolution apparatus in distilled water. The highest solubility (228. 24 mg/mL) as well as % dissolution (99.9) of CXB was obtained with nanoemulsion technique. The results of solubility and dissolution were highly significant using the nanoemulsion technique as compared to other techniques (P < 0.01). All three formulations showed a sustained type of drug release. The best sustained type drug release was obtained with nanoemulsion. This indicated that nanoemulsion can be successfully used for sustained and controlled drug delivery of CXB. Overall these findings suggested that nanoemulsion is a promising vehicle for solubility and dissolution enhancement of CXB.

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Effect of polyvinylpyrrolidone on the crystallinity and dissolution rate of solid dispersions of the antiinflammatory CI-987

Cited by 33 publications

References 12 publications

Improved dissolution of oleanolic acid with ternary solid dispersions

Improved dissolution of oleanolic acid with ternary solid dispersions

Solubility enhancement and physicochemical characterization of carvedilol solid dispersion with Gelucire 50/13

Nanoemulsion: A promising tool for solubility and dissolution enhancement of celecoxib

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