Nanoemulsion: A promising tool for solubility and dissolution enhancement of celecoxib

Shakeel, Faiyaz; Faisal, Mohammed

doi:10.3109/10837450902967954

Cited by 38 publications

(19 citation statements)

References 16 publications

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“…1,2 Since the poorly soluble drugs must be dissolved in the gastrointestinal lumen contents before oral absorption, improving the solubility and dissolution rate of poorly soluble APIs is rapidly becoming the leading hurdle for formulation scientists. 3,4 Consequently, a variety of strategies have been developed to overcome this obstacle for poorly water-soluble APIs, such as solid dispersions, 5,6 nanoemulsion, 7 salt formation, 8 melt extrusion, 9,10 liposomes, 11,12 nanostructured lipid carriers, 13,14 and micellar systems. 15,16 During the past several years, the use of particle size reduction methods to form stable nanosized particles has been proven to be an effective strategy to address this thorny problem.…”

Section: Introductionmentioning

confidence: 99%

Effect of particle size on oral absorption of carvedilol nanosuspensions: in vitro and in vivo evaluation

Liu¹,

Pan²,

He³

et al. 2015

IJN

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The purpose of this work was to explore the particle size reduction effect of carvedilol on dissolution and absorption. Three suspensions containing different sized particles were prepared by antisolvent precipitation method or in combination with an ultrasonication process. The suspensions were characterized for particle size, surface morphology, and crystalline state. The crystalline form of carvedilol was changed into amorphous form after antisolvent precipitation. The dissolution rate of carvedilol was significantly accelerated by a reduction in particle size. The intestinal absorption of carvedilol nanosuspensions was greatly improved in comparison with microsuspensions and solution in the in situ single-pass perfusion experiment. The in vivo evaluation demonstrated that carvedilol nanosuspensions and microsuspensions exhibited markedly increased C max (2.09- and 1.48-fold) and AUC 0− t (2.11- and 1.51-fold), and decreased T max (0.34- and 0.48-fold) in contrast with carvedilol coarse suspensions. Moreover, carvedilol nanosuspensions showed good biocompatibility with the rat gastric mucosa in in vivo gastrointestinal irritation test. The entire results implicated that the dissolution rate and the oral absorption of carvedilol were significantly affected by the particle size. Particle size reduction to form nanosized particles was found to be an efficient method for improving the oral bioavailability of carvedilol.

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Section: Introductionmentioning

confidence: 99%

Effect of particle size on oral absorption of carvedilol nanosuspensions: in vitro and in vivo evaluation

Liu¹,

Pan²,

He³

et al. 2015

IJN

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“…First, their extreme hydrophobicity and their innate tendency to aggregate render them even more difficult to formulate than other tetrapyrrole PS. Nevertheless, there has been many different strategies applied for drug delivery of fullerenes, e.g., liposomes [181–183], micelles [184, 185], dendrimers [186, 187], pegylation [188–191], cyclodextrin [192, 193], and self-nanoemulsifying systems [194–197]. Second, the main absorption of fullerenes is in the blue and green regions of the visible spectrum, rather than the red/NIR where light transmission through tissue is maximized.…”

Section: Fullerenesmentioning

confidence: 99%

Can nanotechnology potentiate photodynamic therapy?

Huang¹,

Sharma²,

Chung³

et al. 2016

Nano Online

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Photodynamic therapy (PDT) uses the combination of nontoxic dyes and harmless visible light to produce reactive oxygen species that can kill cancer cells and infectious microorganisms. Due to the tendency of most photosensitizers (PS) to be poorly soluble and to form nonphotoactive aggregates, drug-delivery vehicles have become of high importance. The nanotechnology revolution has provided many examples of nanoscale drug-delivery platforms that have been applied to PDT. These include liposomes, lipoplexes, nanoemulsions, micelles, polymer nanoparticles (degradable and nondegradable), and silica nanoparticles. In some cases (fullerenes and quantum dots), the actual nanoparticle itself is the PS. Targeting ligands such as antibodies and peptides can be used to increase specifi city. Gold and silver nanoparticles can provide plasmonic enhancement of PDT. Two-photon excitation or optical upconversion can be used instead of one-photon excitation to increase tissue penetration at longer wavelengths. Finally, after sections on in vivo studies and nanotoxicology, we attempt to answer the title question, " can nanotechnology potentiate PDT ? "

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“…Many strategies have been demonstrated or applied to either solubilize or modify fullerenes for improving their utility in drug-delivery and medical applications. The following approaches: liposomes; 47–49 micelles; 50,51 dendrimers; 52,53 PEGylation; 53–56 self-nanoemulsifying systems (SNES); 57–60 encapsulation in cyclodextrins. 47, 61, 62 have all been explored by various groups throughout the world to overcome this problem with fullerenes.…”

Section: Design Of Fullerene Derivativesmentioning

confidence: 99%

Functionalized Fullerenes in Photodynamic Therapy

Huang¹,

Sharma²,

Yin³

et al. 2014

j biomed nanotechnol

114

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Since the discovery of C60 fullerene in 1985, scientists have been searching for biomedical applications of this most fascinating of molecules. The unique photophysical and photochemical properties of C60 suggested that the molecule would function well as a photosensitizer in photodynamic therapy (PDT). PDT uses the combination of non-toxic dyes and harmless visible light to produce reactive oxygen species that kill unwanted cells. However the extreme insolubility and hydrophobicity of pristine C60, mandated that the cage be functionalized with chemical groups that provided water solubility and biological targeting ability. It has been found that cationic quaternary ammonium groups provide both these features, and this review covers work on the use of cationic fullerenes to mediate destruction of cancer cells and pathogenic microorganisms in vitro and describes the treatment of tumors and microbial infections in mouse models. The design, synthesis, and use of simple pyrrolidinium salts, more complex decacationic chains, and light-harvesting antennae that can be attached to C60, C70 and C84 cages are covered. In the case of bacterial wound infections mice can be saved from certain death by fullerene-mediated PDT.

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Nanoemulsion: A promising tool for solubility and dissolution enhancement of celecoxib

Cited by 38 publications

References 16 publications

Effect of particle size on oral absorption of carvedilol nanosuspensions: in vitro and in vivo evaluation

Effect of particle size on oral absorption of carvedilol nanosuspensions: in vitro and in vivo evaluation

Can nanotechnology potentiate photodynamic therapy?

Functionalized Fullerenes in Photodynamic Therapy

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Nanoemulsion: A promising tool for solubility and dissolution enhancement of celecoxib

Cited by 38 publications

References 16 publications

Effect of particle size on oral absorption of carvedilol nanosuspensions: in vitro and in&nbsp;vivo&nbsp;evaluation

Effect of particle size on oral absorption of carvedilol nanosuspensions: in vitro and in&nbsp;vivo&nbsp;evaluation

Can nanotechnology potentiate photodynamic therapy?

Functionalized Fullerenes in Photodynamic Therapy

Contact Info

Product

Resources

About

Effect of particle size on oral absorption of carvedilol nanosuspensions: in vitro and in vivo evaluation

Effect of particle size on oral absorption of carvedilol nanosuspensions: in vitro and in vivo evaluation