Effect of population stratification on SNP‐by‐environment interaction

An, Jaehoon; Won, Sungho; Lutz, Sharon M.; Hecker, Julian; Lange, Christoph

doi:10.1002/gepi.22250

Cited by 7 publications

(2 citation statements)

References 24 publications

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“…All statistical analyses were performed using the R statistical software ver. 3.5 (R Foundation for Statistical Computing, Vienna, Austria), and figures were plotted using the Rex software [ 12 13 ]. P-values of <0.05 were considered statistically significant.…”

Section: Methodsmentioning

confidence: 99%

The prognoses and postoperative outcomes of patients with both colorectal cancer and liver cirrhosis based on a nationwide cohort in Korea

et al. 2020

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Purpose The management of patients with colorectal cancer (CRC) who have liver cirrhosis (LC) requires a thorough understanding of both diseases; however, the prognoses and postoperative outcomes of such patients remain understudied. We investigated the effect of LC on surgical and oncologic outcomes in patients with CRC, and identified prognostic factors. Methods We analyzed 453 patients with CRC and LC (CRC-LC group), 906 with CRC only (CRC group), 906 with LC only (LC group), and 1,812 healthy subjects using health insurance claim data (2008–2013). Results The CRC-LC group had a higher frequency of intensive care unit admission than the CRC group; there were no differences between the 2 groups in terms of early and late postoperative small bowel obstruction and incisional hernia. However, the 30-day, 60-day, and 90-day mortality rates were all significantly higher in the CRC-LC group. The higher Charlson comorbidity index (hazard ratio [HR], 1.127) and the lower socioeconomic status (HR, 0.985) were significant worse predictors of 5-year survival. Patients with underlying LC had a significantly higher HR in both the advanced CRC (HR, 1.858) and nonadvanced CRC (HR, 1.799) subgroups. However, the nonadvanced CRC subgroup showed a lower HR than the LC group (HR, 0.730). Conclusion Patients with CRC who had underlying LC had a lower survival rate than did those without LC, although the incidence rates of postoperative complications were not significantly different. The presence of LC was associated with a significantly lower survival rate regardless of CRC presence.

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Section: Methodsmentioning

confidence: 99%

The prognoses and postoperative outcomes of patients with both colorectal cancer and liver cirrhosis based on a nationwide cohort in Korea

et al. 2020

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“…Population stratification affects the proportion of false positives in genome-wide association analysis. Therefore, corrections are needed to ensure the reliability of the statistical analysis [25][26][27]. Various strategies have been proposed to solve these GWAS-related problems [28,29], and we used three analyses to accurately determine the relationships among the analyzed genotypes.…”

Section: Discussionmentioning

confidence: 99%

A Genome-Wide Association Study Identifies Quantitative Trait Loci Affecting Hematological Traits in Camelus bactrianus

Guo

Liang

et al. 2020

Animals

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Bactrian camels (Camelus bactrianus) are one of the few large livestock species that can survive in the Gobi Desert. Animal immunity and disease resistance are related to hematological traits, which are also associated with tolerance observed in Bactrian camels. However, no genome-wide association studies have examined the genetic mechanism of the immune capability of Bactrian camels. In the present study, we used genotyping-by-sequencing data generated from 366 Bactrian camel accessions to perform a genome-wide association study for 17 hematological traits. Of the 256,616 single-nucleotide polymorphisms (SNPs) obtained, 1,635 trait–SNP associations were among the top quantitative trait locus candidates. Lastly, 664 candidate genes associated with 13 blood traits were identified. The most significant were ZNF772, MTX2, ESRRG, MEI4, IL11, FRMPD4, GABPA, NTF4, CRYBG3, ENPP5, COL16A1, and CD207. The results of our genome-wide association study provide a list of significant SNPs and candidate genes, which offer valuable information for further dissection of the molecular mechanisms that regulate the camel’s hematological traits to ultimately reveal their tolerance mechanisms.

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Genome-wide association study for growth-related traits in golden pompano (Trachinotus ovatus)

Zhu

Sun

Jiang³

et al. 2023

Aquaculture

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Effect of population stratification on SNP‐by‐environment interaction

Cited by 7 publications

References 24 publications

The prognoses and postoperative outcomes of patients with both colorectal cancer and liver cirrhosis based on a nationwide cohort in Korea

The prognoses and postoperative outcomes of patients with both colorectal cancer and liver cirrhosis based on a nationwide cohort in Korea

A Genome-Wide Association Study Identifies Quantitative Trait Loci Affecting Hematological Traits in Camelus bactrianus

Genome-wide association study for growth-related traits in golden pompano (Trachinotus ovatus)

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