Effect of Post–Myocardial Infarction Exercise Training on the Renin-Angiotensin-Aldosterone System and Cardiac Function

Effect of endurance exercise training on morphological changes in rat heart tissue following experimental myocardial infarction

“…Increasing of wall pressure during exercise training is known as the reason of left ventricle dilation. It has been observed that the increase in the size of the LV is to be intensified after the exercise that began 3 weeks after MI, and is thought that early exercise after MI may be responsible for adverse LV remodeling (12). Exercise training immediately after MI, when necrosis and inflammation are high, may lead to increasing of LV pressure and thinning of infarcted wall that continues by collagen deposition in the thin wall, leading to LV remodeling (18).…”

“…These results are consistent with results of Gaudron (1994) and Jugdutt (1998), but inconsistent with de Waard, Xu, Serra and Orenstein results that reported the beneficial effects of exercise following MI. Several factors such as different experimental methods, the infarct size, type of activity, intensity and duration of activity may play a role in different effects of exercise following MI, as well as the onset time of exercise following MI may play an important role in cardiac remodeling after MI because inflammatory reactions caused by MI, fibrosis and scar formation occur at different stages after infarction (12). Therefore, from the reasons for inconsistent results of this investigation with above ones can be noted different methods of MI induction, duration of activity and the onset time of exercise following MI.…”

“…However, Gaudron et al (1994) reported that endurance swim training, 4 and 21 days after coronary artery occlusion cause no LV remodeling in rats with small infarct, but in rats with large infarct, early endurance training aggravated the remodeling of LV and increased mortality (11). In study by Wan et al (2007), 8 weeks of running on a treadmill, 1 and 6 weeks after MI, independent of its inception, caused non-significant increase in the infarct size in exercise groups compared with sedentary control group and cardiac tissue remodeling were similar in both training protocol (12). Orenstein et al (1995) reported that exercise training following MI in rats, can improve the adverse remodeling process by attenuating ventricular dilation and reducing wall tension (13).…”

Efeitos sequenciais do treinamento aeróbio sobre o sistema renina-angiotensina em núcleos autonômicos de ratos normotensos e hipertensos.

“…Em um trabalho pioneiro Hespel et al (1988) mostraram em adultos saudáveis que a atividade da renina plasmática correlacionava-se negativamente com o aumento da atividade física. Demonstrou-se também que a habilidade do treinamento em reverter déficits induzidos pela insuficiência associava-se a redução da hiperatividade do SRA (GADEMAN et al, 2007;KAR;ZUCKER, 2010;WAN, et al, 2007). A potencialidade do treinamento aeróbio em bloquear a hiperatividade do SRA cardíaco foi também observada na hipertensão espontânea (FERNANDES et al, 2011;GOMES FILHO et al, 2008).…”

Mecanismos associados ao desenvolvimento das complicações do diabetes tipo 2 em camundongos fêmeas ob/ob: papel preventivo do treinamento físico dinâmico aeróbio, resistido ou combinado

“…Em ratos infartados, o treinamento fisico realizado em intensidade moderada foi capaz de reduzir a angiotensina 2, a ECA, a renina e a aldosterona (WAN et al, 2007). A redução da angiotensina 2 em resposta a um programa de treinamento físico também foi observada em pacientes (BRAITH et al, 1999) e em coelhos (LIU et al, 2000) com insuficiência cardíaca.…”