Effect of postmenopausal estrogen replacement therapy on lipoproteins

Omu, Alexander E.; Al-Qattan, N.

doi:10.1016/0020-7292(95)02578-2

Cited by 5 publications

(2 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Estrogen with progestogen Lee et al [36]b Prospective ↓ PEPI Trial Group [44] Prospective ↓ ↑ ↑ Crook et al [45] Prospective ↓ ↓ ↓ Nabulsi et al [46] Cross-sectional ↓ ↑ No change ↓ Barnes et al [47] Prospective ↓ No change Farish et al [48] Prospective ↓ ↓ ↓ Jensen et al [49] Prospective ↓ ↑ No change Heikkinen et al [50] Prospective ↓ Omu and Al-Qattan [51] Prospective No change No change No change Hirvonen et al [52] Prospective ↓ No change or ↓ c Tilly-Keisi et al [53] Prospective ↓ Hanggi et al [54] Prospective ↑ ↑ a Oral ingestion lead to an increase in triglycerides, transdermal administration to a decrease. b No distinction was made between unopposed estrogen use and a combination of estrogen and progestogen.…”

Section: No Change No Changementioning

confidence: 98%

The Effect of Hormone Replacement Therapy and Exercise on Cardiovascular Disease Risk Factors in Postmenopausal Women

et al. 2000

View full text Add to dashboard Cite

Following menopause, women show an increased risk of heart disease to a level equal that of men. This elevated risk is thought to be due, at least partly, to changes in blood lipid and fibrinogen levels. The purpose of this article is to review the published research on the relationship between both exercise and hormone replacement with regards to common cardiovascular disease (CVD) risk factors and the relative importance of each. Menopause is associated with increased total serum cholesterol, triglycerides and fibrinogen, and a decrease in high density lipoprotein (HDL) cholesterol levels. The major reason for these changes following menopause is believed to be a result of fluctuations in hormonal status, primarily a deficiency in estrogen. Intervention may be justified since estrogen replacement therapy has been shown to decrease the risk of developing CVD and to have a significant impact on many of the CVD risk factors. The results vary from study to study, but generally estrogen replacement has been found to decrease total cholesterol and fibrinogen, while increasing HDL cholesterol and triglycerides. All of these changes, other than the increase in triglycerides, are seen as positive. The addition of progestogen to estrogen may negate some of the beneficial changes of estrogen, most notably the increase in HDL cholesterol levels. However, progestogen has also been reported to offset the increase in triglycerides seen with unopposed estrogen replacement. Thus, there are contradictory effects (both positive and negative) of hormone replacement on CVD risk factors in women. Regular aerobic exercise and resulting improvements in cardiorespiratory fitness have consistently been shown as preventive of CVD. This decreased CVD risk is in part because of the impact of exercise on blood lipids and fibrinogen. Increased aerobic exercise is thought to improve the risk profile, mainly through an increase in HDL cholesterol levels and decreases in triglycerides and fibrinogen. Unfortunately, the majority of research supporting the effects of exercise on CVD risk factors has been done on men. Even when research has included women, very few studies have focused on postmenopausal women. However, the research done on postmenopausal women points to a significantly improved CVD risk factor profile with regular cardiorespiratory exercise.

show abstract

Section: No Change No Changementioning

confidence: 98%

The Effect of Hormone Replacement Therapy and Exercise on Cardiovascular Disease Risk Factors in Postmenopausal Women

et al. 2000

View full text Add to dashboard Cite

show abstract

“…O aumento significativo e progressivo nas médias do HDL colesterol quando comparadas às variações do terceiro ano com as iniciais foram, também, constatadas em estudos observacionais, transversais e prospectivos coreano, ingleses e suiço envolvendo usuárias e não usuárias de reposição hormonal (Kim et al, 1996;Crook et al, 1997;Hanggi et al, 1997;Valdlamudi et al, 1998). Entretanto, outras pesquisas observacionais prospectivas e, inclusive, ensaios clínicos randomizados com mulheres portadoras de doença arterial coronariana, usuárias e não usuárias de terapia hormonal, não evidenciaram variações ou constataram discreta diminuição das concentrações de HDL colesterol associadas, particularmente, ao tipo de progesterona utilizado (Pepi Trial, 1995;Omu Al Qattan et al, 1996;Os et al, 2000).…”

Section: Discussionunclassified

Menopausa e fatores de risco associados a doença cardiovascular

Raskin¹

View full text Add to dashboard Cite

AgradecimentosAo Matias, pelas horas dedicadas à realização deste trabalho. Dizer obrigado é pouco para uma gratidão que, com palavras, dificilmente seria traduzida.Ao professor Aarão: nada teria sentido nesta hora se não reconhecesse a sabedoria daquele que deposita em cada um de nós, a esperança de um crescimento contínuo, de uma vitória.Obrigada pela confiança, pela compreensão, pelo apoio, pelo tempo dedicado só para acrescentar.

show abstract

Is physical activity as effective in reducing risk of cardiovascular disease as estrogen replacement therapy in postmenopausal women?

Wong

1999

International Journal of Nursing Studies

View full text Add to dashboard Cite

Effect of postmenopausal estrogen replacement therapy on lipoproteins

Abstract: There was no demonstrably clear effect of the estrogen-progestin combination on lipoprotein levels, probably because of other compounding variables such as obesity, lack of exercise and the type of progestin used.

Cited by 5 publications

References 21 publications

The Effect of Hormone Replacement Therapy and Exercise on Cardiovascular Disease Risk Factors in Postmenopausal Women

The Effect of Hormone Replacement Therapy and Exercise on Cardiovascular Disease Risk Factors in Postmenopausal Women

Menopausa e fatores de risco associados a doença cardiovascular

Is physical activity as effective in reducing risk of cardiovascular disease as estrogen replacement therapy in postmenopausal women?

Contact Info

Product

Resources

About