Effect of postnatal treadmill exercise on c-Fos expression in the hippocampus of rat pups born from the alcohol-intoxicated mothers

Sim, Young-Je; Kim, Hong; Shin, Mal‐Soon; Chang, Hyun‐Kyung; Shin, Min-Chul; Ko, Il‐Gyu; Kim, Ki-Jeong; Kim, Tea-Soo; Kim, Bo-Kyun; Rhim, Yong-Taek; Kim, Sangho; Park, Ho-Yoon; Yi, Jae-Woo; Lee, SamJun

doi:10.1016/j.braindev.2007.07.003

Cited by 25 publications

(22 citation statements)

References 57 publications

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“…The mouse had a peak Blood Alcohol Concentration (BAC) around 200–250 mg dl −1 within a half hour after an administration. This falls in a range between the consumption levels by social drinkers (60 mg dl −1 ) and those by chronic alcoholics (320–620 mg dl −1 )5657, and is also similar to that used in previous studies reporting pathological and molecular effects of fetal alcohol exposure5859. The human in vitro model used the same range of EtOH concentration (50 mM (230 mg dl −1 )), by which several aspects of FASD phenotypes have been shown to be induced in the mouse cerebral cortex in vitro 60.…”

Section: Methodssupporting

confidence: 79%

Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling

Ishii¹,

Torii²,

Son³

et al. 2017

Nat Commun

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Repetitive prenatal exposure to identical or similar doses of harmful agents results in highly variable and unpredictable negative effects on fetal brain development ranging in severity from high to little or none. However, the molecular and cellular basis of this variability is not well understood. This study reports that exposure of mouse and human embryonic brain tissues to equal doses of harmful chemicals, such as ethanol, activates the primary stress response transcription factor heat shock factor 1 (Hsf1) in a highly variable and stochastic manner. While Hsf1 is essential for protecting the embryonic brain from environmental stress, excessive activation impairs critical developmental events such as neuronal migration. Our results suggest that mosaic activation of Hsf1 within the embryonic brain in response to prenatal environmental stress exposure may contribute to the resulting generation of phenotypic variations observed in complex congenital brain disorders.

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Section: Methodssupporting

confidence: 79%

Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling

Ishii¹,

Torii²,

Son³

et al. 2017

Nat Commun

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“…Further, exercise also rescued deficits on Morris Water Maze performance along with open field performance that resulted from a third trimester equivalent (PD4-9; 5.25 g/kg/day) alcohol exposure. 83 In addition, exercise can enhance long-term potentiation in the perforant pathway in prenatally exposed animals, 81 and it can also increase hippocampal expression of immediate early gene c-Fos, which is a marker of neuronal activation, 91 suggesting that anatomical changes may be correlated with behavioral changes.…”

Section: Exercise As An Intervention For Fasdmentioning

confidence: 98%

Exercise Regulation of Cognitive Function and Neuroplasticity in the Healthy and Diseased Brain

Hamilton¹,

Rhodes²

2015

Progress in Molecular Biology and Translational Science

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“…To detect c-Fos expression, immunohistochemistry was performed as previously described (Sim et al 2008). On average, 10 sections were selected from each brain in the region spanning from Bregma (9.68 to (9.80 mm for the PMC and from Bregma (7.64 to (8.00 mm for the vlPAG.…”

Section: Immunohistochemistry For C-fosmentioning

confidence: 99%

“…The specimens were transversely step-sectioned in 10 mm thicknesses using a freezing microtome (Leica, Nussloch, Germany) to include the urethral injection sites. Brain tissue was prepared at 8 weeks after the injection of human ADSCs as previously described (Sim et al 2008). Briefly, the rats were perfused transcardially with 50 mM PBS, and then fixed with a freshly prepared solution consisting of 4% paraformaldehyde (PFA) in 100 mM phosphate buffer (PB; pH 7.4) after harvest of the bladder and urethra.…”

Section: Tissue Preparationmentioning

confidence: 99%

Transplantation of human adipose-derived stem cells into the urethra ameliorates stress urinary incontinence and blunts the induction of c-Fos immunoreactivities in brain areas related to micturition in female rats

Kim

et al. 2010

Animal Cells and Systems

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Stress urinary incontinence (SUI) is a common condition that primarily affects women. Here, we investigate the effects of human adipose-derived stem cells (ADSCs) in a rodent model of SUI. Female Sprague-Dawley rats at 7 weeks of age were randomly divided into three groups (n 08 per group): sham-operation, SUI-induction by transabdominal urethrolysis, and SUI-induction followed by transplantation of human ADSCs into the urethra. The abdominal leak point pressure at 8 weeks after the operation was markedly decreased by transabdominal urethrolysis, confirming successful induction of SUI. Interestingly, transplantation of human ADSCs into the urethra significantly blunted the decrease of abdominal leak point pressure in SUI-induced rats. Accordingly, we observed expression of a-smooth muscle actin in a significant proportion of transplanted ADSCs, indicating differentiation of ADSCs into smooth muscle cells in the urethra. Moreover, the SUI-induced elevations of c-Fos immunoreactivities in the pontine micturition center (PMC) and in the ventrolateral periaqueductal gray (vlPAG) were clearly suppressed by transplantation of human ADSCs. These results imply that human ADSCs can be an effective therapeutic modality to ameliorate the symptoms of SUI.

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Effect of postnatal treadmill exercise on c-Fos expression in the hippocampus of rat pups born from the alcohol-intoxicated mothers

Cited by 25 publications

References 57 publications

Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling

Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling

Exercise Regulation of Cognitive Function and Neuroplasticity in the Healthy and Diseased Brain

Transplantation of human adipose-derived stem cells into the urethra ameliorates stress urinary incontinence and blunts the induction of c-Fos immunoreactivities in brain areas related to micturition in female rats

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