Effect of potassium fluoride on the micellar behavior of Pluronic F-68 in aqueous solution

Effects of block architecture and composition on the association properties of poly(oxyalkylene) copolymers in aqueous solution

“…Association numbers and radii of micelles of block copoly(oxyalkylene)s have been largely determined by conventional dynamic and static light scattering methods, with supporting results for hydrodynamic radius coming from PGSE-NMR 50,69,[134][135][136] , and GPC 59,96) . Results derived predominantly from these techniques (described below) are discussed in this section.…”

“…In relation to EPE copolymers, there are a number of reports on the effect of added salts 69,71,134,136,180) , including the sphere-to-cylinder transition, and the area has been briefly reviewed 10) . It is useful to distinguish salts with large polarisable anions (e. g. NaCNS) from the others (e. g. NaCl) in relation to their effect on the aqueous solubility of poly(oxyethylene) as identified, most rigorously, by its theta temperature (h) 39,40,188) , addition of NaCNS increasing h (i. e. increasing solubility, salting in) and addition of NaCl reducing h (decreasing solubility, salting out).…”

Effect of Salts on the Micellization, Clouding, and Solubilization Behavior of Pluronic F127 Solutions

“…F127 has been used in formulating thermoreversible gels for transdermal, injectable, and controlled delivery of hydrophilic and hydrophobic drugs. A few reports have appeared showing that inorganic salts influence the micellization (1-7), clouding (3)(4)(5), and gelation (6,(8)(9)(10) behavior of selected Pluronic copolymers. Most pharmaceutical F127 solutions and gels contain buffers and other salts (11)(12)(13)(14), so understanding their effects on the gelation, clouding, and micellization of F127 is important.…”

“…Several workers have studied the effect of 1.0 M KF on various PEO-PPO-PEO copolymers. Bahadur et al (3) found that the cloud point (CP) and cmt of F-68 solutions were lowered by 1.0 M KF. The authors subsequently studied salt (KF, KCl, KBr, and KCNS) effects on L-64 and P-85 and found that salts altered the aggregation number and solubilization ability of these copolymers (4).…”

Development of Novel Polymeric Materials for Gene Therapy and pH-Sensitive Drug Delivery: Modeling, Synthesis, Characterization, and Analysis

“…In addition, most studies use an experimental setup that is stirred in such a way that the agitation rate influences the release rate by adding shear on the geyliquid surface [30,32,34]. In other cases, experimental setups were used where the gel was trapped by a membrane [31,33].…”